Attainment of treatment goals by people with Alzheimer's disease receiving galantamine: a randomized controlled trial

Assessing methods to specify the target difference for a randomised controlled trial: DELTA (Difference ELicitation in TriAls) review

“…Other outcomes of interest included disability, functional ability, goal attainment, speech function and cognitive ability. In considering change, some studies often used a clinician to assess subjects' health, 282,287,290,293,301,303 whereas others used the subjects' self-assessment 292,297,302,[309][310][311] or both 296,299,312,313 (not necessarily for the same instrument). The view of the parents of children who were being treated was often used in studies in paediatric care along with clinical and/or child assessment.…”

“…The view of the parents of children who were being treated was often used in studies in paediatric care along with clinical and/or child assessment. [314][315][316] Similarly, Rockwood and colleagues 312 used the combined judgement of the patient and the caregiver as well as the clinician's assessment. Basoglu and colleagues 291 used one instrument that was administered by a clinician, but it was unclear whether the patient or the clinician completed other instruments.…”

Diagnosis and treatment of dementia: 5. Nonpharmacologic and pharmacologic therapy for mild to moderate dementia

“…The attainment of treatment goals was used successfully as an outcome measure in a randomized controlled trial of galantamine. 45 Prescribing physicians should be aware of the regulations of their province's drug benefit program for coverage of these drugs and help their patients obtain reimbursement when appropriate.…”

Pharmacotherapy of Alzheimer Disease

“…This instrument covers 5 domains with 20 items that are more sensitive to changes in severe dementia and will provide a more useful assessment of treatment response in this group of patients. The GAS 52,53 may also prove useful if adapted to the more severe stages of AD.…”