Atteinte hépatosplénique de la maladie des griffes du chat : à propos de deux observations chez l'immunocompétent

SystemicBartonella henselaeInfection in Immunocompetent Adult Presenting as Fever of Unknown Origin

“…Splenic CSD can easily be mistaken for splenic lymphoma, thereby leading to unnecessary splenectomy [13]. Bartonella serology must be achieved in case of hepatosplenic nodules with fever [2, 14]. …”

“…Treatment of disseminated CSD in immunocompetent adult is still empirical and recovery can occur without antibiotherapy [2]. In the recent pediatric survey of Scolfaro and coll.…”

“…Cat scratch disease (CSD) caused by Bartonella henselae is a well-recognized benign cause of localized lymphadenopathy in immunocompetent patients, especially children [1, 2]. CSD seldom affects other organ systems, such as the liver and spleen [3].…”

Diagnosis and follow-up of Bartonella henselae infection in the spleen of an immunocompetent patient by real-time quantitative PCR

“…On the other hand in immunocompromised subjects, B. henselae infection is associated with angiogenesis, in which a neutrophilic inflammatory response to bacilli located within the skin, bone and other organs (bacillary angiomatosis) or the liver and spleen (peliosis) is seen (Zenone, 2011). Visceral CSD occurs mainly in immunocompromised patients (Liston & Koehler, 1996), although the literature shows that a significant number of immunocompetent patients do suffer from disseminated CSD (Renou et al, 2010;Family-Pigné et al, 2006), which is transmitted by different mechanisms (Bass et al, 1997;McGill et al, 2003). In visceral CSD, preliminary diagnosis by radiology assessment must be confirmed by serology and molecular methods.…”