Atteintes neuropsychiatriques au cours de la sclérodermie systémique

Launay, David; Baubet, Thierry; Cottencin, Olivier; Bérezné, Alice; Zephir, Hélène; Morell-Dubois, Sandrine; Pruvo, Jean‐Pierre; Guillevin, Loı̈c; Hatron, Pierre‐Yves; Hachulla, É.; Mouthon, Luc

doi:10.1016/j.lpm.2009.10.004

Cited by 14 publications

(4 citation statements)

References 47 publications

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“…Thus, it was important to assess anxiety/depressive symptoms and self-esteem. Prevalence of depressive symptoms, as assessed by the HADS score, was signi cantly higher in cases than in controls, with values comparable to those in the literature (Launay and al., 2010). We did not nd differences in anxiety symptoms between the two groups.…”

Section: Discussionsupporting

confidence: 87%

Perception of aesthetic impairment in patients with systemic sclerosis using a semi-quantitative scale and association with disease characteristics.

Farhat

Guerreschi

Morell-Dubois

et al. 2022

Preprint

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Background: Systemic sclerosis (SSc) is a fibrotic disease. Assessment of body image could be central in optimizing care. Yet, data are scarce. The main objective was to assess perception of aesthetic impairment using a visual aesthetic scale (AES) in patients with SSc compared to healthy subjects. Secondary objectives were to assess associations between perception of aesthetic impairment and standardized questionnaires for aesthetic impairment as well as clinical, psychological/quality of life, and functional parameters of SSc. Methods: This study evaluated and compared perception of aesthetic impairment in two populations: patients with SSc, in a referral center at Lille Hospital, France, and healthy controls. Results: This study included 88 patients (69 [78.4%] women) with a median age of 52 years and 88 controls (49 [55.7%] women) with a median age of 45 years. Perception of aesthetic impairment assessed using the AES was poorer in patients than in controls (3.7 ± 0.3 vs 2.8 ± 0.3, p=0.028), with statistical correlation with ASWAP, a specific aesthetic impact assessment questionnaire for patients with SSc. Patients with anxiety or depressive symptoms had significantly higher AES scores. SSc patients with facial involvement and pitting scars had a worse perception of aesthetic impairment. SSc patients have a worse perception of aesthetic impairment than healthy controls, especially in SSc patients with anxiety or depression and those with facial and hand involvement. Conclusion: The AES appears to be an ease of use tool to evaluate body image. Correlations found with psychological and quality of life parameters reflect the importance of these parameters for body image evaluation and its complex assessment. Trial registration: Clinical Trial NCT03271320. Registered 09 January 2017, https://www.clinicaltrials.gov/ct2/show/NCT03271320?term=NCT03271320&cntry=FR&draw=2&rank=1

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Section: Discussionsupporting

confidence: 87%

Perception of aesthetic impairment in patients with systemic sclerosis using a semi-quantitative scale and association with disease characteristics.

Farhat

Guerreschi

Morell-Dubois

et al. 2022

Preprint

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“…A functional magnetic resonance study on patients with fibromyalgia showed enhancement of activity in anterior cingulate and insular cortex during the experience of acute pain [28]: significantly, these regions of CNS are responsible of the affective processing of pain. More recent work suggests that, the focus has been shifted to understand the consequence of vascular and micro-vascular CNS involvement in SSc (hyperintense foci of variable size diffuse in white matter), and is thought to be a form of CNS vasculopathy, similar to the Systemic Lupus Erythematosus [2, 29]. Other autoimmune diseases have also cause characteristic pattern of cerebral perfusion anomalies related to mood disorders [30, 31].…”

Section: Resultsmentioning

confidence: 99%

Psychiatric Symptoms and Quality of Life in Systemic Sclerosis

Mura

Bhat²,

Pisano

et al. 2012

CPEMH

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Introduction: Systemic sclerosis (SSc) is a rare conjunctive tissue disorder characterized by fibrosis of the skin and internal organs, and vascular obliteration phenomena. Patients with SSc often experience elevated symptoms of psychological distress, determined by the disfiguration, the pain, the fatigue sensation, and the difficult in daily life occupations. The characteristics of the disease may influence the perceived quality of life (QoL) in people with SSc.Methods: This is a narrative review aiming to define the amount of impairment of Quality of Life in patients with Systemic Sclerosis and the component of this impairment due to depressive or other psychiatric symptoms. The search of the significant articles was carried out in PubMed for the key words “Psychiatric symptoms and Systemic Sclerosis”; “Quality of life and Systemic Sclerosis”; “Depressive Disorders and Systemic Sclerosis”.Results: Psychiatric symptoms are frequents in patients with SSc, but pain, fatigue, disability, body changes don’t appear to explain the high prevalence of psychiatric comorbidity in SSc. Many studies founded a significant impairment in SSc patients’ QoL, and despite the undeniable correlation between physical symptoms and SSc patients’ QoL, mental health was found significantly impaired.Discussion: The high rate of depression seems to strictly correlate with poor quality of life, and this finding needs more research to establish the cause of such a correlation. Patients’ point of view regarding their health-related QoL could help physicians to enlarge the knowledge about physical and mental correlates of the disease, and to fit therapies as patient required. Particular attention must be given to provide the patient with correct information, in order to mitigate the anxious state on disease course, and to enhance coping skills of the patients.

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“…9 These spectroscopy data can be suggestive of inflammatory and demyelination mechanism. 10,11 In this case, the 'cause and effect' relationship between myelopathy and systemic sclerosis was discussed. Spinal cord involvement was observed in 8% of cases in a series by Averbuch-Heller et al, which included 50 patients with scleroderma.…”

Section: Discussionmentioning

confidence: 96%