Attempted suicide and completed suicide in traumatic spinal cord injury. Case reports

Harris, E Clare; Barraclough, B. M.; Grundy, D; Bamford, E; Inskip, Hazel

doi:10.1038/sc.1996.138

Cited by 13 publications

(6 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First, a high percentage of people with SCI have sustained their injury through attempted suicide, for which the majority of the sample has been reported to have MHD. 2 This supports the relationship between the presence of an MHD and the incident of suicide attempt.…”

Section: Introductionsupporting

confidence: 68%

Rehabilitation outcomes in people with pre-morbid mental health disorders following spinal cord injury

2008

View full text Add to dashboard Cite

All patients were involved in a multidisciplinary Goal Planning and Needs Assessment Rehabilitation Programme. Rehabilitation outcomes were measured using the Needs Assessment Checklist (NAC), which has been specifically designed for use with people with SCI. It is a reliable and valid clinical assessment tool, which provides a means to assess and facilitate the delivery of an individually tailored rehabilitation programme. Results: No significant difference was found between the MHD and non-MHD groups for rehabilitation outcomes. The MHD group showed higher achieved independence scores in psychology for the first needs assessment. Overall, both groups were found to make significant improvements in their level of independence for all nine areas of need between the first and second NAC administration. Conclusion: Results suggest that rehabilitation can be tailored to meet the individual needs of patients with SCI having MHD; however, further research comparing these outcomes with other rehabilitation approaches is required. The function of timely psychological support for MHD patients on admission to the NSIC has been suggested as a potential explanation for rehabilitation performance. Most importantly, rehabilitation outcomes of patients with MHD have not been found to differ significantly compared with those without MHD.

show abstract

Section: Introductionsupporting

confidence: 68%

Rehabilitation outcomes in people with pre-morbid mental health disorders following spinal cord injury

2008

View full text Add to dashboard Cite

show abstract

“…Babidge et al (2001) reported that men with schizophrenia committed suicide at significantly younger ages (in their twenties) than those without schizophrenia. However, other studies have reported equal rates (Modestin et al, 1992;Harris et al, 1996).…”

Section: Introductionmentioning

confidence: 88%

Differing correlates for suicide attempts among patients with schizophrenia or schizoaffective disorder in India and USA

Bhatia

Thomas

Semwal

et al. 2006

Schizophrenia Research

View full text Add to dashboard Cite

Background-Suicide is one of the most common causes of death among persons with schizophrenia. Differing risk factors have been identified in published studies. The differences may have arisen because a uniform set of variables was not analyzed. Alternatively, the nature and effect of risk factors may vary in different settings. To test these possibilities, we investigated the same set of variables in two independent cross-national samples ascertained using identical protocols.Methods-Patients with schizophrenia or schizoaffective disorder (DSM IV criteria) were recruited in India (n=460) and the USA (n=424).Results-Consistent with earlier publications, a diagnosis of schizoaffective disorder, history of depression, pattern of symptoms and educational status were significantly associated with suicide attempts in the US sample. None of these variables were significantly associated in the Indian sample.Conclusions-The impact of known risk factors for suicide attempts among patients with schizophrenia differs across ethnic groups.

show abstract

“…The majority of people with SCI suffer from devastating chronic neuropathic pain syndromes that are so severe that depression, drug abuse and suicide often result (Cairnes et al, 1996; Harris et al, 1996; McKinley et al, 1999). SCI produces dramatic alterations in synaptic circuits relaying somatotopic sensory transmission in the dorsal horn.…”

Section: Glial Activation On Central Neuropathic Pain Following Scimentioning

confidence: 99%

Spatial and temporal activation of spinal glial cells: Role of gliopathy in central neuropathic pain following spinal cord injury in rats

Gwak

Kang

Unabia

et al. 2012

Experimental Neurology

237

198

View full text Add to dashboard Cite

In the spinal cord, neurons and glial cells actively interact and contribute to neurofunction. Surprisingly, both cell types have similar receptors, transporters and ion channels and also produce similar neurotransmitters and cytokines. The neuroanatomical and neurochemical similarities work synergistically to maintain physiological homeostasis in the normal spinal cord. However, in trauma or disease states, spinal glia become activated, dorsal horn neurons become hyperexcitable contributing to sensitized neuronal-glial circuits. The maladaptive spinal circuits directly affect synaptic excitability, including activation of intracellular downstream cascades that result in enhanced evoked and spontaneous activity in dorsal horn neurons with the result that abnormal pain syndromes develop. Recent literature reported that spinal cord injury produces glial activation in the dorsal horn; however, the majority of glial activation studies after SCI have focused on transient and/or acute time points, from a few hours to one month, and peri-lesion sites, a few millimeters rostral and caudal to the lesion site. In addition, thoracic spinal cord injury produces activation of astrocytes and microglia that contributes to dorsal horn neuronal hyperexcitability and central neuropathic pain in above-level, at-level and below-level segments remote from the lesion in the spinal cord. The cellular and molecular events of glial activation are not a simple event, rather it is the consequence of a combination of several neurochemical and neurophysiological changes following SCI. The ionic imbalances, neuroinflammation and alterations of cell cycle proteins after SCI are predominant components for neuroanatomical and neurochemical changes that result in glial activation. More importantly, SCI induced release of glutamate, proinfloammatory cytokines, ATP, reactive oxygen species (ROS) and neurotrophic factors trigger activation of postsynaptic neurons and glial cells via their own receptors and channels that, in turn, contribute to neuronal-neuronal and neuronal-glial interaction as well as microglia-astrocytic interactions. However, a systematic review of temporal and spatial glial activation following SCI has not been done. In this review, we describe time and regional dependence of glial activation and describe activation mechanisms in various SCI models in rats. These data are placed in the broader context of glial activation mechanisms and chronic pain states. Our work in the context of work by others in SCI models demonstrate that dysfunctional glia, a condition called “gliopathy”, are key contributors in the underlying cellular mechanisms contributing to neuropathic pain.

show abstract

Attempted suicide and completed suicide in traumatic spinal cord injury. Case reports

Cited by 13 publications

References 1 publication

Rehabilitation outcomes in people with pre-morbid mental health disorders following spinal cord injury

Rehabilitation outcomes in people with pre-morbid mental health disorders following spinal cord injury

Differing correlates for suicide attempts among patients with schizophrenia or schizoaffective disorder in India and USA

Spatial and temporal activation of spinal glial cells: Role of gliopathy in central neuropathic pain following spinal cord injury in rats

Contact Info

Product

Resources

About