Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia

Chong, Siow‐Ann; Lee, Wei-Ling; Tan, C.S.; Hou-NgeeTay, Agnes; Chan, A.O.M.; Tan, Ene‐Choo

doi:10.1016/s0165-1781(00)00229-8

Cited by 48 publications

(20 citation statements)

References 22 publications

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“…In contrast to these positive findings a variety of studies did not observe an association of the 5-HTTLPR with suicidality, neither in post-mortem studies 75 nor in studies investigating DNA of suicide attempters from Caucasian, 93,94 Chinese 95,96 or Jewish Ashkeanzi origin. 97 Even an increased frequency of the low-activity L-allele was observed within a patient group with increased hopelessness and suicide ideation.…”

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confidence: 72%

Genetics of suicide

2006

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The concept that genetic factors contribute to the complex trait of suicidal behaviour has stimulated much work aimed at identifying susceptibility genes. So far molecular genetic studies focused on the serotonergic pathway as the intent to die and the lethality of suicide acts were related to the serotonergic system. Two genes have so far emerged as being involved in the vulnerability for suicidality: first, the intronic polymorphisms (A218C or A779C) of the tryptophan hydroxylase 1 (TPH1) gene, which was suggested as a quantitative risk factor for suicidal behaviour; second, the insertion/deletion polymorphism of the serotonin transporter gene (5-HTTLPR), which does not seem to be involved in general suicidal behaviour, but in violent and repeated suicide attempts. The data have further shown that the MAOA gene, which is consistently associated with impulsive-aggressive personality traits, is not related to suicide but might induce violent methods in subjects with other suicide risk factors. Predominantly negative were the findings with any type of the serotonin receptors and inconsistent with catecholamine-synthesizing and -metabolizing enzymes or with the dopaminergic receptors. This paper reviews the status of current knowledge in this area, points to the weakness of the investigations and presents new approaches beyond the serotonergic system.

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confidence: 72%

Genetics of suicide

2006

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“…Over the last few years, at least 14 studies have been conducted in which the hypothesis tested was whether polymorphisms in the SERT gene are associated with suicide. Seven of these studies failed to demonstrate any link between suicidal behavior and SERT genotype or 5-HTTLPR allele frequency (Ohara et al, 1998;Chong et al, 2000;Geijer et al, 2000;Ho et al, 2000;Mann et al, 2000;Fitch et al, 2001;Rujescu et al, 2001). The remaining seven studies all found some association, albeit with differing results (Du et al, 1999;Bellivier et al, 2000;Bondy et al, 2000;Gorwood et al, 2000;Russ et al, 2000;Courtet et al, 2001;Baca-Garcia et al, 2002).…”

Section: Genetics Of Sertmentioning

confidence: 97%

“…Perhaps, these latter studies were unable to find an effect of the s allele, because the sample was comprised of patients with suicidal behavior that was not violent or lethal. Additionally, two of the studies were conducted in Asian populations (Ohara et al, 1998;Chong et al, 2000), which have been shown to have a higher frequency of the s allele than Caucasian populations (Gelernter et al, 1999). Therefore, any effect of the s form of the 5-HTTLPR on suicidal behavior would require larger sample sizes than would be needed in Caucasian populations.…”

Section: Genetics Of Sertmentioning

confidence: 99%

Serotonin Transporter: A Potential Substrate in the Biology of Suicide

Purselle

Nemeroff

2002

Neuropsychopharmacol

102

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Suicide is a serious public health problem in the US, yet its neurobiological underpinnings are poorly understood. Suicide is highly correlated with depressive symptoms, and considerable evidence suggests that depression is associated with a relative deficiency in serotonergic neurotransmission. Serotonergic circuits also mediate impulsivity, a trait obviously relevant to suicide. These findings, taken together, suggest that alterations in the serotonergic system might contribute to suicidal behavior, serving as an impetus for researchers to scrutinize the serotonin transporter (SERT) as a potential substrate for the pathophysiology of suicide. Using post-mortem brain tissue, platelets, and DNA from suicide completers and attempters have not provided unequivocal evidence for a pre-eminent role for the SERT in the pathophysiology of suicide. This paper provides a review of several studies that have evaluated the role of the SERT in the pathophysiology of suicide.

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“…18,19,[28][29][30][31][32][33][34][35][36][37] Again, the study by Faludi et al 27 was excluded because it did not provide genotype or allele frequencies. The study by Mann et al 38 could not be included in our analysis because it did not provide information on genotype or allele frequencies for controls, as they only reported comparisons between suicides and deceased depressed subjects.…”

Section: -Htt Transportermentioning

confidence: 99%

A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior

2003

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The different serotonin (5-HT) receptors, including the serotonin transporter (5-HTT), are excellent candidate genes for suicide and suicidal behavior, and thus, they have been investigated in a large number of allelic association studies. The individual results of these studies have been inconsistent and definite conclusions are difficult to establish. A reliable method for assessing individual studies and generating combined results is provided by systematic reviews using meta-analytical techniques. In this study, we carried out a systematic review of studies investigating 5-HT receptors and the 5-HTT in suicidal behavior. Studies were identified by means of MEDLINE database searches and by scanning reference lists. More than 190 articles were reviewed and 26 met the inclusion criteria. In all, 14 studies investigated six different 5-HT receptor loci and 12 studies investigated the 5-HTT promoter 44 bp insertion/ deletion polymorphism. Two specific meta-analyses were carried out, pooling studies investigating the 5-HT2A 102 T/C and the 5-HTT promoter loci that included, respectively, a total of 1599 and 2539 subjects. The combined evidence was significant for association with the 5-HTT locus (Mantel-Haenszel weighted odds ratio (M-H w OR) ¼ 1.17 CI : 1.04-1.32, P ¼ 0.009), but not for the 5-HT2A 102 T/C variant (M-H w OR) ¼ 1.09 CI : 0.93-1.27, P ¼ 0.319). The 5-HTT result was robust and remained significant following sensitivity analysis, suggesting that 5-HTT may play a role in the predisposition to suicide.

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Attempted suicide and polymorphism of the serotonin transporter gene in Chinese patients with schizophrenia

Cited by 48 publications

References 22 publications

Genetics of suicide

Genetics of suicide

Serotonin Transporter: A Potential Substrate in the Biology of Suicide

A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior

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