Attempts to Assay the Enterotoxic Substance Produced by Staphylococci by ParenteralInjection of Monkeys and Kittens

The Production of Staphylococcus Enterotoxin and Alpha Hemolysin in a Simplified Medium

“…One of us (W. McD. H.) has recently made an analysis of the various tests (soon to be published). It was found that of the several tests described, the intravenous injection of the toxin in cats as recommended by Davison, Dack and Cary (1938), and by Davison and Dack (1939) was the most practical and specific in 175 instances in which it was used. No reaction was interpreted as positive unless vomiting occurred, since diarrhea and pyrexia may result from the inoculation of other materials.…”

Thermal inactivation of staphylococcal enterotoxin B with changing pH, protein concentration, and ionic strength

“…Heating, addition of formalin and the use of antiserum to non-enterotoxigenie strains which was proposed by Davison et (1938) were not fully satisfactory and had disadvantages» After the development of purification procedures for the different enterotoxins, animal tests gave more reliable information.…”

Thermal inactivation of staphylococcal enterotoxin B with changing pH, protein concentration, and ionic strength

“…Obviously, the difficulties encountered in the use of animal tests ufua L. t y w wc cw cue la^rv 01 all aucy uoLC i h c l i i u u i c i i do 1 a u * 1 ly Lite cii cci o~ toxin from the other staphylococcal toxins. Heating, addition of formalin and the use of antiserum to non-enterotoxigenie strains which was proposed by Davison et (1938) were not fully satisfactory and had disadvantages» After the development of purification procedures for the different enterotoxins, animal tests gave more reliable information.…”