Attempts to produce megasyndrome in mice using stocks of Trypanosoma cruzi associated with megaoesophagus in man

Marsden, Philip D.; Alvarenga, Nelson J.; Soares, V.A.; Gama, M.P.

doi:10.1016/0035-9203(79)90013-0

Transactions of the Royal Society of Tropical Medicine and Hygi

1979

DOI: 10.1016/0035-9203(79)90013-0

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Attempts to produce megasyndrome in mice using stocks of Trypanosoma cruzi associated with megaoesophagus in man

Philip D. Marsden

Nelson J. Alvarenga

V.A. Soares

et al.

Abstract: Two stocks of Trypanosoma cruzi isolated from patients with advanced megaoesophagus produced megastomach in chronically infected mice. The mice showed evidence of stomach dilatation and a delay in intestinal transit time. These findings are discussed in the light of the hypothesis that regional variations in T. cruzi determines mega formation in man.

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1983

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Cited by 5 publications

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Animal models for exploring Chagas disease pathogenesis and supporting drug discovery

Khan,

Taylor,

Fortes Francisco

et al. 2024

Clin Microbiol Rev

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SUMMARY Infections with the parasitic protozoan Trypanosoma cruzi cause Chagas disease, which results in serious cardiac and/or digestive pathology in 30%–40% of individuals. However, symptomatic disease can take decades to become apparent, and there is a broad spectrum of possible outcomes. The complex and long-term nature of this infection places a major constraint on the scope for experimental studies in humans. Accordingly, predictive animal models have been a mainstay of Chagas disease research. The resulting data have made major contributions to our understanding of parasite biology, immune responses, and disease pathogenesis and have provided a platform that informs and facilitates the global drug discovery effort. Here, we provide an overview of available animal models and illustrate how they have had a key impact across the field.

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Animal models for exploring Chagas disease pathogenesis and supporting drug discovery

Khan,

Taylor,

Fortes Francisco

et al. 2024

Clin Microbiol Rev

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Seqüência dos estudos sobre a produção experimental de megassíndromes em camundongos

Soares¹,

Gama²,

Alvarenga³

et al. 1983

Rev. Soc. Bras. Med. Trop.

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Recentemente demonstrou-se que cepas de Trypanosoma cruzi, isoladas de pacientes apre sentando megaesôfago, puderam produzir megaestômago em camundongos após cerca de 1 ano de infecção1. Megaestômago pode ser detectado em animais vivos por contraste de bário, sendo que não se detectou ocorrência de megaesôfago ou megacólon nos animais infectados, nem mesmo pela autópsia, embora estes animais apresentassem uma sensível demora de tem po no trânsito intestinal, quando comparados com animais normais.No sentido de estender essas observações, in vestigou-se a capacidade de produção de "Megas" a partir de cepas de diferentes origens, bem como seu com portam ento em comparação com uma das cepas utilizadas no trabalho citado acima.Foram feitas observações sobre a acuidade do m étodo de medida do perfil radiográfico do es tômago como medida alternativa e válida do volu me deste mesmo órgão.

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Comportamento de uma cepa de Trypanosoma cruzi isolada de um paciente com megaesôfago em camundongos C3H

Soares

Chapadeiro

Castro

et al. 1984

Rev. Soc. Bras. Med. Trop.

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Attempts to produce megasyndrome in mice using stocks of Trypanosoma cruzi associated with megaoesophagus in man

Cited by 5 publications

References 3 publications

Animal models for exploring Chagas disease pathogenesis and supporting drug discovery

Animal models for exploring Chagas disease pathogenesis and supporting drug discovery

Seqüência dos estudos sobre a produção experimental de megassíndromes em camundongos

Comportamento de uma cepa de Trypanosoma cruzi isolada de um paciente com megaesôfago em camundongos C3H

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