Attention-deficit hyperactivity disorder, its treatment with medication and the probability of developing a depressive disorder: A nationwide population-based study in Taiwan

Lee, Min Jing; Yang, Kuo‐Chung; Shyu, Yu-Chiau; Yuan, Shin Sheng; Yang, Chun; Lee, Sheng Yu; Lee, Tung Liang; Wang, Liang‐Jen

doi:10.1016/j.jad.2015.09.015

Cited by 41 publications

(30 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Gurkan and coworkers, a 3‐month period of MPH treatment (mean dose, 24.2 mg/day) in 45 naïve children with ADHD (mean age, 10.09 ± 1.80) improved significantly the children's life quality and significantly decreased depression, anxiety, and compulsion symptoms (Gurkan et al, 2010). Lee and coworkers also reported that long‐term MPH had a protective role against the development of depressive disorders in children with ADHD (mean age, 9.3 ± 3.2) when compared with the control group (Lee et al, 2016). Regarding the adult population, a 12‐week, multicenter, open‐label trial also concluded that MPH (mean dose, 56.1 mg/day) improved the psychological health of 60 adults (aged 18–65 years old) with ADHD (Mattos et al, 2013).…”

Section: Methylphenidate (Mph)mentioning

confidence: 95%

“…In fact, ADHD itself may be associated with comorbid psychiatric disorders, including affective, anxiety, and depression disorders (Pliszka, 1998). Recently, Lee and coworkers showed that ADHD patients had a significantly higher likelihood of developing a depressive disorder when compared to those without ADHD (Lee et al, 2016). According to Gurkan and coworkers, a 3-month period of MPH treatment (mean dose, 24.2 mg/day) in 45 naïve children with ADHD (mean age, 10.09 ± 1.80) improved significantly the children's life quality and significantly decreased depression, anxiety, and compulsion symptoms (Gurkan et al, 2010).…”

Section: Cns Effects Of Mph On Humansmentioning

confidence: 99%

See 1 more Smart Citation

Methylphenidate effects in the young brain: friend or foe?

Loureiro-Vieira

Costa

Bastos

et al. 2017

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Attention deficit hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatry disorders in children and adolescents, and methylphenidate (MPH) is a first-line stimulant drug available worldwide for its treatment. Despite the proven therapeutic efficacy, concerns have been raised regarding the possible consequences of chronic MPH exposure during childhood and adolescence. Disturbances in the neurodevelopment at these crucial stages are major concerns given the unknown future life consequences. This review is focused on the long-term adverse effects of MPH to the brain biochemistry. Reports conducted with young and/or adolescent animals and studies with humans are reviewed in the context of long-term consequences after early life-exposure. MPH pharmacokinetics is also reviewed as there are differences among laboratory animals and humans that may be relevant to extrapolate the findings. Studies reveal that exposure to MPH in laboratory animals during young and/or adolescent ages can impact the brain, but the outcomes are dependent on MPH dose, treatment period, and animal's age. Importantly, the female sex is largely overlooked in both animal and human studies. Unfortunately, human reports that evaluate adults following adolescent or child exposure to MPH are very scarce. In general, human data indicates that MPH is generally safe, although it can promote several brain changes in early ages. Even so, there is a lack of long course patient evaluation to clearly establish whether MPH-induced changes are friendly or foe to the brain and more human studies are needed to assess the adult brain changes that arise from early MPH treatment.

show abstract

Section: Methylphenidate (Mph)mentioning

confidence: 95%

Section: Cns Effects Of Mph On Humansmentioning

confidence: 99%

Methylphenidate effects in the young brain: friend or foe?

Loureiro-Vieira

Costa

Bastos

et al. 2017

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

show abstract

“…In this study, we used the propensity score matching technique to create a matching control with a ratio of 1:1 for the ADHD group. The propensity scores were determined using multivariate logistic regression analysis with gender and birth year as the confounding covariates . We determined an index date for each matched control, which was established as the ADHD diagnosis date from its matching ADHD case.…”

Section: Methodsmentioning

confidence: 99%

“…The propensity scores were determined using multivariate logistic regression analysis with gender and birth year as the confounding covariates. 33,34 We determined an index date for each matched control, which was established as the ADHD diagnosis date from its matching ADHD case. This study utilizes the aforementioned matched index dates to reduce potential temporal biases for subsequent survival analysis.…”

Section: Selection Of the Control Groupmentioning

confidence: 99%

Correlation between attention‐deficit/hyperactivity disorder, its pharmacotherapy and thyroid dysfunction: A nationwide population‐based study in Taiwan

Chen

Shyu

Tsai

et al. 2018

Clinical Endocrinology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Between 57% and 87% of children and adolescents with ADHD may have at least one comorbidity, and about 20% have three or more comorbid conditions, such as Tourette syndrome, bipolar disorder, posttraumatic stress disorder, and obsessive-compulsive disorder [12][13][14]. These comorbidities frequently accompany sleep problems [15].…”

Section: Introductionmentioning

confidence: 99%

Behavioural sleep problems in previously untreated children with attention deficit hyperactivity disorder

Eyüboğlu

2017

Psychiatry and Clinical Psychopharmacology

View full text Add to dashboard Cite

OBJECTIVE: Although sleep symptoms are not included in the diagnostic criteria of attention deficit hyperactivity disorder (ADHD), these problems are common in children with ADHD. The presence of sleep problems was associated with impairment in functionality and increase in ADHD intensity. The aims of the study were to evaluate sleep problems of children with ADHD who had never received any psychiatric treatment and investigate the effects of these problems in functionality. METHODS: The present study included 83 children who were diagnosed as having ADHD and had never received any psychiatric treatment. The control group consisted of 106 healthy children. Psychiatric diagnostic interview was applied to all children. The parents completed the Conner's Parent Questionnaire to evaluate the intensity of ADHD in the children, the Children's Sleep Habits Questionnaire (CSHQ) to evaluate sleep problems, and the Weiss Functional Impairment Rating Scale to evaluate the functionality of the children. RESULTS: The total scores of subscale and scales of CSHQ were significantly higher in the study group. ADHD children slept 1 hour later and sleep quantity was 1.5 hours less than the control group. There was a significant correlation between sleep problems, ADHD severity, and functionality of these children. CONCLUSIONS:The results demonstrated that children with ADHD experienced more sleep problems and slept less than the children in the healthy control group, and functional impairments increased due to these problems. Another important finding is that sleep problems are not related to drug use. Maintaining sleep hygiene or interventions against sleep problems may increase sleep quality and may improve self and family functionality. Therefore, the standardized sleep evaluation must be performed in cooperation with parents in all children with ADHD. ARTICLE HISTORY

show abstract

Attention-deficit hyperactivity disorder, its treatment with medication and the probability of developing a depressive disorder: A nationwide population-based study in Taiwan

Cited by 41 publications

References 47 publications

Methylphenidate effects in the young brain: friend or foe?

Methylphenidate effects in the young brain: friend or foe?

Correlation between attention‐deficit/hyperactivity disorder, its pharmacotherapy and thyroid dysfunction: A nationwide population‐based study in Taiwan

Behavioural sleep problems in previously untreated children with attention deficit hyperactivity disorder

Contact Info

Product

Resources

About