Attention–deficit/hyperactivity disorder symptoms, perceived stress, and suicidal ideation during the COVID-19 pandemic

Stickley, Andrew; Shirama, Aya; Inagawa, Takuma; Ruchkin, Vladislav; Koposov, Roman; Isaksson, Johan; Inoue, Yosuke; Sumiyoshi, Tomiki

doi:10.3389/fpsyt.2022.1008290

Cited by 4 publications

(3 citation statements)

References 76 publications

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“…[65] The crusade in the search to minimize the evils of neurodegenerative diseases ranges or computing resources from the search for possible correlated microorganisms to dysfunctional behavioral patterns and biomarkers. [66][67][68][69] The more we study AD we realize that the breadth of the topic requires the formation of multidisciplinary teams for research. [70] No matter how distant computer science may seem from philosophy, from genetics to psychology, everything is connected in the search for better aging.…”

Section: Discussionmentioning

confidence: 99%

A Pilot Study to Research Associations between Alzheimer’s Disease and Suicide: The Questionnaire Feasibility

Rodrigues,

Atalaia da Silva

et al. 2024

Preprint

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Background: There have been reports of numerous risk factors for Alzheimer's disease. Although widely investigated, some points during the evolution of the disease have been obscure. One of them is a great frustration with therapeutic expectations. Why has there been an increase in suicidal behavior in treatments with anti-beta-amyloid drugs? Interpersonal stress is one of the factors that may be connecting Alzheimer's disease to suicide. Method: To observe possible associations between Alzheimer's disease and suicide, two validated questionnaires were selected. We recruited 20 elderly patients over 65 years old to observe the feasibility of further research using these instruments. The study was considered viable if all participants showed no difficulty in understanding the questions and completed both questionnaires in less than 30 minutes with a tendency to homogeneity. A description of the statistical data obtained was made. Results: All participants adequately understood the questions and completed the questionnaires in less than 30 minutes. In 10% of the sample, suicide attempts occurred throughout their lives. The average age of respondents was 75 years old. The QoSL Pareto diagram demonstrated a large concentration. The data demonstrated homogeneity. Conclusions: The application of the questionnaires in a sample suitable for carrying out analytical statistics was demonstrated. We have two great tools to try to understand the possible association between Alzheimer's disease and suicide.

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Section: Discussionmentioning

confidence: 99%

A Pilot Study to Research Associations between Alzheimer’s Disease and Suicide: The Questionnaire Feasibility

Rodrigues,

Atalaia da Silva

et al. 2024

Preprint

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“…Several studies suggested a negative psychological impact of the COVID-19 pandemic quarantines on mental health of the paediatric population worldwide, with an increasing number of the reported new diagnosis of mental disorders in children and adolescents over time since the outbreak in March 2020 [5][6][7][8][9][10][11]. Anxiety, depression, sleep disorders, and eating disorders resulted to be among the leading causes of illness and disability in this population [12][13][14][15][16][17][18][19][20][21]. Moreover, children with pre-existing behavioral disorders, such as autism spectrum disorders or ADHD had a high probability of worsening of their behavioral symptoms, probably also due to difficulties in accessing to child neuropsychiatry support services for pandemic containment measures [22][23][24][25][26][27][28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Impact of COVID-19 pandemic on prescription of psychotropic medications in the Italian paediatric population during 2020

Gallinella,

Trotta,

Fortinguerra

2024

Ital J Pediatr

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Background There is a global perception that psychotropic utilization in children and adolescents is increasing, especially with the onset of COVID-19 pandemic. Available literature data on paediatric psychotropic medication prescriptions in Italy are limited to one or few regions and not updated. The aim of this study was to provide updated data on psychotropic prescriptions referred to the whole Italian paediatric population, as overall and by subgroups of medications and to evaluate if the COVID-19 pandemic during 2020 had an impact on prescription rates. Methods A descriptive study on psychotropic drug utilization in children and adolescents (< 18 years) resident in all Italian regions during 2020 was performed. Patients registered in the Pharmaceutical Prescriptions database with at least one prescription/dispensing of a psychotropic medication (antipsychotics-N05A), (antidepressants-N06A) and (psychostimulants-N06BA) during the study period were considered. The indicators used were the prescription rate (number of prescriptions per 1000 children) and prevalence of use (proportion of the paediatric population with at least one prescription in the relevant year). Results During the 2020 the prevalence of psychotropic drug use in the paediatric population was 0.3%, increased of 7.8% if compared to 2019. The same trend was observed for the prescription rate, which recorded an average of 28.2 per 1000 children with an increase of 11.6% if compared to previous year, representing the 0.6% of the overall drug use in this age group. The data showed a growing trend prescription by age, reaching the peak in adolescents aged 12–17 years old, with a prescription rate of 65 per 1000 children and a prevalence of 0.71%. Considering the subgroups of psychotropic medications, the highest prevalence of use was found for antipsychotic drugs, received by the 0.19% of the paediatric population during 2020. Conclusions Psychotropic drug utilization in children and adolescents has grown during 2020 in Italy and worldwide, raising alarms from health care clinicians and patient advocates about the increase of burden of mental diseases in paediatric population during the COVID-19 pandemic. A more systematic monitoring of the use of psychotropic medications should be implemented in all countries for collecting relevant information about children and adolescents taking psychotropic drugs, in order to address the present and the future of the mental health of the paediatric population.

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“…Comorbid substance use disorders significantly potentiated the risk of severe COVID-19 ( 14 ). Beyond that, perceived stress increased the risk for suicidal ideation in individuals with ADHD symptoms in an adult Japanese sample ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

Female sex and burden of depressive symptoms predict insufficient response to telemedical treatment in adult attention-deficit/hyperactivity disorder: results from a naturalistic patient cohort during the COVID-19 pandemic

Praus,

Proctor,

Rohrmann

et al. 2023

Front. Psychiatry

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BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a chronic neuropsychiatric disorder, that typically manifests itself during childhood and persists in a majority of the affected individuals into adulthood, negatively affecting physical and mental health. Previous studies have shown detrimental effects of the COVID-19 pandemic on mental health in individuals with ADHD. Thus, telemedicine could be a useful tool for optimizing treatment-outcomes in adult ADHD by improving treatment adherence and persistence. However, data on telemedical treatment outcomes in adult patients with ADHD is scarce.MethodsWe report here the sub-cohort analysis of a naturalistic cohort of adult patients (N = 254) recruited between April 2020–April 2021, comparing the effects of telemedical treatment on participants either clinically diagnosed with depression (N = 54) or ADHD (N = 67). Participants were asked to fill out the WHO-5 repetitively during >12 weeks of telemedical treatment. Furthermore scores of WHO-5, SCL-90R and BDI-II, psychopathology, psychosocial functioning, sociodemographic data, medical records and a feedback survey were analyzed for both groups and compared. Participants with ADHD were further stratified according to the development of well-being during the study period in order to identify factors associated with a satisfactory treatment outcome.ResultsParticipants with depression reported a significant improvement of well-being during the course of the study, while no such effect could be seen in participants with ADHD on a group level. Despite the good outcome, participants with depression were more severely affected at baseline, with significantly worse psychopathology and a more precarious labor and financial situation. A detailed analysis of ADHD participants without clinical improvement revealed significantly higher BDI-II scores than for ADHD participants with a satisfactory outcome (p = 0.03, Mann–Whitney-U-Test), suggesting successful treatment was hampered by the combination of ADHD and depressive symptoms. Furthermore, female sex among ADHD patients was correlated with an unfavorable treatment outcome during the course of the study (p = 0.001, Spearman correlation) as well as living with children (p = 0.02, Spearman correlation).ConclusionBesides screening for depressive symptoms before telemedical treatment, future research should address the specific needs of female ADHD patients as these patients may be at a particularly high risk of being overburdened with family work.

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Attention–deficit/hyperactivity disorder symptoms, perceived stress, and suicidal ideation during the COVID-19 pandemic

Cited by 4 publications

References 76 publications

A Pilot Study to Research Associations between Alzheimer’s Disease and Suicide: The Questionnaire Feasibility

A Pilot Study to Research Associations between Alzheimer’s Disease and Suicide: The Questionnaire Feasibility

Impact of COVID-19 pandemic on prescription of psychotropic medications in the Italian paediatric population during 2020

Female sex and burden of depressive symptoms predict insufficient response to telemedical treatment in adult attention-deficit/hyperactivity disorder: results from a naturalistic patient cohort during the COVID-19 pandemic

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