Attention/memory complaint is correlated with motor speech disorder in Parkinson’s disease

Abstract

BackgroundThe mechanisms underlying the online modulation of motor speech in Parkinson’s disease (PD) have not been determined. Moreover, medical and rehabilitation interventions for PD-associated motor speech disorder (MSD) have a poor long-term prognosis.MethodsTo compare risk factors in PD patients with MSD to those without MSD (non-MSD) and determine predictive independent risk factors correlated with the MSD phenotype, we enrolled 314 PD patients, including 250 with and 64 without MSD. We compared demographic, characteristic data, as well as PD-associated evaluations between the MSD group and non-MSD group.ResultsUnivariate analysis showed that demographic characteristics, including occupation, educational level, monthly income and speaking background; clinical characteristics, including lesions in the frontal and temporal lobes, and concurrent dysphagia; and PD-associated evaluations, including the activity of daily living (ADL) score, non-motor symptoms scale (NMSS) domain 4 score (perceptual problem), and NMSS domain 5 score (attention/memory) were all significantly different between the MSD and non-MSD group (all P < 0.05). Multivariate logistic regression analysis showed that educational level, frontal lesions, and NMSS domain 5 score (attention/memory) were independent risk factors for PD-associated MSD (all P < 0.005).ConclusionsWe determined an association between MSD phenotype and cognitive impairment, reflected by low-level education and related clinical profiles. Moreover, attention and memory dysfunction may play key roles in the progression of MSD in PD patients. Further studies are required to detail the mechanism underlying abnormal speech motor modulation in PD patients. Early cognitive intervention may enhance rehabilitation management and motor speech function in patients with PD-associated MSD.

Avaliação das habilidades auditivas temporais na doença de Parkinson

“…Os resultados encontrados no presente estudo com relação à escolaridade (Tabela 1) demonstram que grande parte dos indivíduos do GE não completou o ensino fundamental. Desta forma, a baixa escolaridade do grupo pode ser um fator de susceptibilidade ao possível aparecimento da demência 26 .…”

HiCommunication as a novel speech and communication treatment for Parkinson's disease: A feasibility study

“…In addition, central sensory processing abnormalities as well as impaired internal cueing result in reduced awareness of the sound level of the own voice and difficulties with self-regulating adequate loudness (Clark et al, 2014;Ho et al, 2000;Kwan & Whitehill, 2011). Possibly attentional deficits also play a role in difficulties with maintaining adequate loudness in conversation (Liu et al, 2019). Speech symptoms often present quite early in the disease process, contrary to findings in older studies (Rusz et al, 2011(Rusz et al, , 2013Rusz, Hlavnička, et al, 2016.…”

Aging-related decline in the neuromotor control of speech production: current and future

“…Also, evidence from people with cognitive impairment suggests a link between cognitive function and speech production. For example, PD patients with motor speech disorders were associated with greater attention/memory dysfunctions (Liu et al, 2019 ), and individuals with mild cognitive impairment exhibited weaker voice quality and slower articulation rates than healthy controls (Themistocleous et al, 2020 ). Also, Alzheimer's disease (AD) patients exhibited enhanced and prolonged vocal compensations for pitch perturbations that were significantly related to their dysfunctions in working memory and executive control (Ranasinghe et al, 2017 ).…”