Attention modulates activity in the primary and the secondary auditory cortex: a functional magnetic resonance imaging study in human subjects

Jäncke, Lutz; Mirzazade, Shahram; Shah, Nadim Joni

doi:10.1016/s0304-3940(99)00288-8

Cited by 235 publications

(168 citation statements)

References 19 publications

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“…This general attentional effect is consistent with numerous auditory ERP studies (Hillyard et al, 1973;Woldorff et al, 1993; as well as with prior imaging studies using various speech (Grady et al, 1997;Hashimoto et al, 2000;Hugdahl et al, 2000;Hugdahl et al, 2003;Jancke et al, 2001;Jancke et al, 1999;O'Leary et al, 1997;Pugh et al, 1996;Vingerhoets & Luppens, 2001) and nonspeech (Hall et al, 2000;Jancke et al, 2003) auditory stimuli. Contrasts emphasizing speech sound processing (Speech-Rotated) and lexical processing (Word-Pseudoword) showed not only main effects of these stimulus variables but also strong interactions between attention and stimulus type.…”

Section: Discussionsupporting

confidence: 89%

Attentional and linguistic interactions in speech perception

et al. 2008

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The role of attention in speech comprehension is not well understood. We used fMRI to study the neural correlates of auditory word, pseudoword, and nonspeech (spectrally-rotated speech) perception during a bimodal (auditory, visual) selective attention task. In three conditions, Attend Auditory (ignore visual), Ignore Auditory (attend visual), and Visual (no auditory stimulation), 28 subjects performed a one-back matching task in the assigned attended modality. The visual task, attending to rapidly presented Japanese characters, was designed to be highly demanding in order to prevent attention to the simultaneously presented auditory stimuli. Regardless of stimulus type, attention to the auditory channel enhanced activation by the auditory stimuli (Attend Auditory > Ignore Auditory) in bilateral posterior superior temporal regions and left inferior frontal cortex. Across attentional conditions, there were main effects of speech processing (word + pseudoword > rotated speech) in left orbitofrontal cortex and several posterior right hemisphere regions, though these areas also showed strong interactions with attention (larger speech effects in the Attend Auditory than in the Ignore Auditory condition) and no significant speech effects in the Ignore Auditory condition. Several other regions, including the postcentral gyri, left supramarginal gyrus, and temporal lobes bilaterally, showed similar interactions due to the presence of speech effects only in the Attend Auditory condition. Main effects of lexicality (word > pseudoword) were isolated to a small region of the left lateral prefrontal cortex. Examination of this region showed significant word > pseudoword activation only in the Attend Auditory condition. Several other brain regions, including left ventromedial frontal lobe, left dorsal prefrontal cortex, and left middle temporal gyrus, showed attention × lexicality interactions due to the presence of lexical activation only in the Attend Auditory condition. These results support a model in which neutral speech presented in an unattended sensory channel undergoes relatively little processing beyond the early perceptual level. Specifically, processing of phonetic and lexical-semantic information appears to be very limited in such circumstances, consistent with prior behavioral studies.

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Section: Discussionsupporting

confidence: 89%

Attentional and linguistic interactions in speech perception

et al. 2008

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“…Past research has demonstrated that focal attention on a perceptual modality amplifies activity in brain regions underlying that modality (Jancke et al, 1999;Johansen-Berg et al, 2000;Somers et al, 1999 Figure 1 Focused awareness task design. The focused awareness task consisted of three types of trials: interoceptive attention (IA), anxious rumination trials, and exteroceptive trials.…”

Section: Taskmentioning

confidence: 99%

Altered Insula Activity during Visceral Interoception in Weight-Restored Patients with Anorexia Nervosa

Kerr

Moseman

Avery

et al. 2015

Neuropsychopharmacol

134

123

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Anorexia nervosa (AN) is a devastating psychiatric illness that is associated with significant morbidity and mortality. Aberrant visceral interoceptive processing within the insula has been hypothesized to be an important mechanism in AN's pathophysiology due to the theoretical link between interoception and emotional experience. We therefore utilized functional magnetic resonance imaging (fMRI) to examine whether altered insula functioning underlies visceral interoception in AN. Fifteen females with restricting-type AN and 15 healthy control females underwent fMRI while performing an interoceptive attention task during which they focused on sensations in their heart, stomach, and bladder. Participants also performed an anxious rumination task while in the scanner. AN participants were weight-restored and free of psychotropic medications. Two distinct regions of the insula-anterior insula and dorsal mid-insula-exhibited a significant (po0.05) interaction between group and interoceptive modality. The post hoc analyses revealed that in the dorsal mid-insula the interaction was driven by group differences during stomach interoception (p = 0.002, Bonferroni corrected), whereas in the anterior insula the interaction was driven by group differences during heart interoception (p = 0.03, Bonferroni corrected). In addition, individuals with AN displayed increased activation during anxious rumination in the dorsal mid-insula, and activation in this region during stomach interoception was correlated with measures of anxiety and psychopathology. This relationship between altered visceral interoception and clinical symptoms in AN suggests an important mechanism for the disorder. Additional research is needed to examine whether interventions targeting visceral interoception may increase the efficacy of treatments for AN.

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“…There are various reasons that can explain apparent discrepancies across studies, like differences between the applied neuroimaging techniques, differences in the data analysis strategies (Kriegeskorte et al 2009), the spectral characteristics and dynamic range of acoustic stimuli, the limited number of participants per study (Genovese et al 1997;Thirion et al 2007), their age (Hegerl et al 1994), their attention to acoustic stimuli (Jäncke et al 1999), their musical experience and musical ability (Schneider et al 2005), their personality traits (Juckel et al 1995;Röhl and Uppenkamp 2010), their emotional states (Quirk et al 1997), or their neurotransmission (Juckel et al 2008). The effect of these factors needs to be considered to reveal the neuronal underpinning of loudness sensation.…”

Section: Introductionmentioning

confidence: 99%

Neural Coding of Sound Intensity and Loudness in the Human Auditory System

Röhl

Uppenkamp

2012

JARO

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Inter-individual differences in loudness sensation of 45 young normal-hearing participants were employed to investigate how and at what stage of the auditory pathway perceived loudness, the perceptual correlate of sound intensity, is transformed into neural activation. Loudness sensation was assessed by categorical loudness scaling, a psychoacoustical scaling procedure, whereas neural activation in the auditory cortex, inferior colliculi, and medial geniculate bodies was investigated with functional magnetic resonance imaging (fMRI). We observed an almost linear increase of perceived loudness and percent signal change from baseline (PSC) in all examined stages of the upper auditory pathway. Across individuals, the slope of the underlying growth function for perceived loudness was significantly correlated with the slope of the growth function for the PSC in the auditory cortex, but not in subcortical structures. In conclusion, the fMRI correlate of neural activity in the auditory cortex as measured by the blood oxygen level-dependent effect appears to be more a linear reflection of subjective loudness sensation rather than a display of physical sound pressure level, as measured using a sound-level meter.

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Attention modulates activity in the primary and the secondary auditory cortex: a functional magnetic resonance imaging study in human subjects

Cited by 235 publications

References 19 publications

Attentional and linguistic interactions in speech perception

Attentional and linguistic interactions in speech perception

Altered Insula Activity during Visceral Interoception in Weight-Restored Patients with Anorexia Nervosa

Neural Coding of Sound Intensity and Loudness in the Human Auditory System

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