Attentional biases in irritable bowel syndrome patients

Tkalčić, Mladenka; Domijan, Dražen; Pletikosić, Sanda; Šetić, Mia; Hauser, Goran

doi:10.1016/j.clinre.2014.02.002

Cited by 19 publications

(25 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While both groups had brain responses to the cued pain expectation which presumably carries similar salience for both groups, the IBS subjects showed relatively larger responses in brain regions involved in salience detection, emotional arousal, and self‐consciousness during contextual threat. We speculate that these brain findings are related to hypervigilance and heightened reactivity particularly to the uncertainty of threat previously reported in IBS and anxiety disorders . Future studies that directly manipulate contextual cues and predictability will be important to follow‐up on these findings and compare these results across other chronic pain conditions.…”

Section: Discussionmentioning

confidence: 62%

Altered brain responses in subjects with irritable bowel syndrome during cued and uncued pain expectation

Hong

Naliboff

Labus

et al. 2015

Neurogastroenterology Motil

View full text Add to dashboard Cite

Background A majority of subjects with irritable bowel syndrome (IBS) show increased behavioral and brain responses to expected and delivered aversive visceral stimuli during controlled rectal balloon distension, and during palpation of the sigmoid colon. We aimed to determine if altered brain responses to cued and uncued pain expectation are also seen in the context of a noxious somatic pain stimulus applied to the same dermatome as the sigmoid colon. Methods A task-dependent functional magnetic resonance imaging technique was used to investigate the brain activity of 37 healthy controls (18 females) and 37 IBS subjects (21 females) during: 1) a cued expectation of an electric shock to the abdomen versus a cued safe condition; and 2) an uncued cross-hair condition in which the threat is primarily based on context versus a cued safe condition. Key Results Regions within the salience, attention, default mode, and emotional arousal networks were more activated by the cued abdominal threat condition and the uncued condition than in the cued safe condition. During the uncued condition contrasted to the cued safe condition, IBS subjects (compared to healthy control subjects) showed greater brain activations in the affective (amygdala, anterior insula) and attentional (middle frontal gyrus) regions, and in the thalamus and precuneus. These disease-related differences were primarily seen in female subjects. Conclusions & Inferences The observed greater engagement of cognitive and emotional brain networks in IBS subjects during contextual threat may reflect the propensity of IBS subjects to overestimate the likelihood and severity of future abdominal pain.

show abstract

Section: Discussionmentioning

confidence: 62%

Altered brain responses in subjects with irritable bowel syndrome during cued and uncued pain expectation

Hong

Naliboff

Labus

et al. 2015

Neurogastroenterology Motil

View full text Add to dashboard Cite

show abstract

“…53 Selective recall of negative and gastrointestinal sensation words, as well as selective attention to threat-related stimuli, has been demonstrated in patients with IBS. 93–96 Furthermore, a reduction in the effective connectivity of the central executive network circuitry (including parietal, dorsal lateral prefrontal cortex) during repeated exposure to the anticipation and experience of a threatening gastrointestinal stimulus (repeated exposure to balloon inflations) was associated with a reduction in IBS hypersensitivity. 97 Data from a sample of Japanese patients with IBS, compared with healthy controls, indicated that alterations in error feedback mechanisms were associated with decreased dorsolateral prefrontal cortex activity.…”

Section: The Nervous System Componentmentioning

confidence: 99%

Towards a systems view of IBS

Mayer

Labus

Tillisch

et al. 2015

Nat Rev Gastroenterol Hepatol

224

220

View full text Add to dashboard Cite

Despite an extensive body of reported information about peripheral and central mechanisms involved in the pathophysiology of IBS symptoms, no comprehensive disease model has emerged that would guide the development of novel, effective therapies. In this Review, we will first describe novel insights into some key components of brain–gut interactions, starting with the emerging findings of distinct functional and structural brain signatures of IBS. We will then point out emerging correlations between these brain networks and genomic, gastrointestinal, immune and gut-microbiome-related parameters. We will incorporate this new information, as well as the reported extensive literature on various peripheral mechanisms, into a systems-based disease model of IBS, and discuss the implications of such a model for improved understanding of the disorder, and for the development of more-effective treatment approaches in the future.

show abstract

“…The chronic pain literature, in particular, has employed these experimental methods to test the role of hypervigilance to pain (Crombez, Van Ryckeghem, Eccleston, & Van Damme, 2013) as well as pain-related interpretations of ambiguous information (Schoth & Liossi, 2016). Experimental research has begun to be carried out in other long-term conditions such as chronic fatigue syndrome (CFS) (Hughes et al, 2016), irritable bowel syndrome (Afzal, Potokar, Probert, & Munaf o, 2006;Chapman & Martin, 2011;Tkalcic, Domijan, Pletikosic, Setic, & Hauser, 2014), and fear of cancer recurrence (Butow et al, 2015;Custers et al, 2015;DiBonaventura, Erblich, Sloan, & Bovbjerg, 2010;Miles, Voorwinden, Mathews, Hoppitt, & Wardle, 2009). However, to date, evidence for cognitive biases in these areas has been mixed.…”

Section: What Does This Study Add?mentioning

confidence: 99%

“…More specific and distinct types of stimuli are needed to help refine our models and allow for stimulus-specific predictions. Whilst some material development and validation work have been carried out in some studies (Andersson & Haldrup, 2003;Crombez, Hermans, & Adriaensen, 2000;Keogh, Ellery, Hunt, & Hannent, 2001;Moss-Morris & Petrie, 2003), many fail to thoroughly address this issue, selecting materials from previous literature without validation (Dehghani, Sharpe, & Nicholas, 2003), gaining ratings of stimuli from unrelated populations (Martin & Alexeeva, 2010;Tkalcic et al, 2014), or failing to report how materials were selected or categorized (Asmundson, Carleton, & Ekong, 2005;Roelofs, Peters, Fassaert, & Vlaeyen, 2005).…”

Section: What Does This Study Add?mentioning

confidence: 99%

Maximizing potential impact of experimental research into cognitive processes in health psychology: A systematic approach to material development

Hughes

Gordon

Chalder

et al. 2016

British J Health Psychol

View full text Add to dashboard Cite

This article highlights the value of preforming rigorous stimuli development and provides tools to aid researchers engage in this process. We believe this work is worthwhile to establish a body of high-quality and replicable experimental research within the health psychology literature. Statement of contribution What is already known on this subject? Cognitive biases (e.g., tendencies to attend to negative information and/or interpret ambiguous information in negative ways) have a causal role in maintaining anxiety and depression. There is mixed evidence of cognitive biases in physical health conditions and chronic illness; one reason for this may be the heterogeneous stimuli used to assess attention and interpretation biases in these conditions. What does this study add? Steps for comprehensive/robust stimuli development for attention and interpretation paradigms are presented. Illustrative examples are provided from two conditions: chronic fatigue syndrome and breast cancer. We provide tools to help researchers develop condition-specific materials for experimental studies.

show abstract

Attentional biases in irritable bowel syndrome patients

Cited by 19 publications

References 33 publications

Altered brain responses in subjects with irritable bowel syndrome during cued and uncued pain expectation

Altered brain responses in subjects with irritable bowel syndrome during cued and uncued pain expectation

Towards a systems view of IBS

Maximizing potential impact of experimental research into cognitive processes in health psychology: A systematic approach to material development

Contact Info

Product

Resources

About