Attentional Modulation of Spatial Integration of Pain: Evidence for Dynamic Spatial Tuning

Quevedo, Alexandre Silva de; Coghill, Robert C.

doi:10.1523/jneurosci.3356-07.2007

Cited by 78 publications

(99 citation statements)

References 50 publications

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“…We propose that this might effectively enhance the LC-forebrain signalling temporally linked to noxious events, increasing the attention to pain perception in CCI-stress. Indeed, studies in patients have shown that attention to pain enhances perceived pain [34,42]. It has been shown in awake animals that the LC facilitates different behavioural outcomes by shifting between tonic and phasic modes of discharge [4,40].…”

Section: Discussionmentioning

confidence: 99%

Social stress exacerbates the aversion to painful experiences in rats exposed to chronic pain: The role of the locus coeruleus

Bravo

Alba-Delgado

Torres-Sánchez

et al. 2013

Pain

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a b s t r a c tStressful experiences seem to negatively influence pain perception through as yet unknown mechanisms. As the noradrenergic locus coeruleus (LC) nucleus coordinates many components of the stress response, as well as nociceptive transmission, we evaluated whether the sensory and affective dimension of chronic neuropathic pain worsens in situations of stress due to adaptive changes of LC neurons. Accordingly, male rats were socially isolated for 5 weeks, and in the last 2 weeks, neuropathic pain was induced by chronic constriction injury. In this situation of stress, chronic pain selectively heightened the animal's aversion to painful experiences (affective pain), as measured in the place escape/avoidance test, although no changes were observed in the sensory dimension of pain. In addition, electrophysiological recordings of LC neurons showed a low tonic but exacerbated nociceptive-evoked activity when the injured paw was stimulated. These changes were accompanied by an increase in tyrosine hydroxylase and gephyrin expression in the LC. Furthermore, intra-LC administration of bicuculline, a c-aminobutyric acid-A receptor antagonist, attenuated the negative affective effects of pain. These data show that changes in the LC are greater than those expected from the simple summation of each independent factor (pain and stress), revealing mechanisms through which stressors may exacerbate pain perception without affecting the sensorial dimension. Ó

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Section: Discussionmentioning

confidence: 99%

Social stress exacerbates the aversion to painful experiences in rats exposed to chronic pain: The role of the locus coeruleus

Bravo

Alba-Delgado

Torres-Sánchez

et al. 2013

Pain

View full text Add to dashboard Cite

show abstract

“…Apart from hopefully provoking such reflexive DNIC behavior observed in the rat, this procedure implicates substantial attentional effects, e.g., toward your foot in ice water and distraction from heterotopic stimuli, which alone has been convincingly shown to modulate pain processing and perception (7,63). Many studies have now used this or similar models to test for a potential failure of the DNIC in patients and reported impaired DNIC responses for a variety of chronic pain conditions (36,47,57) or recently even pre-operative pain free patients who develop post-surgical pain (92).…”

Section: Discussionmentioning

confidence: 99%

Imaging CNS Modulation of Pain in Humans

2008

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Pain is a highly complex and subjective experience that is not linearly related to the nociceptive input. What is clear from anecdotal reports over the centuries and more recently from animal and human experimentation is that nociceptive information processing and consequent pain perception is subject to significant pro- and anti-nociceptive modulations. These modulations can be initiated reflexively or by contextual manipulations of the pain experience including cognitive and emotional factors. This provides a necessary survival function since it allows the pain experience to be altered according to the situation rather than having pain always dominate. The so-called descending pain modulatory network involving predominantly medial and frontal cortical areas, in combination with specific subcortical and brain stem nuclei appears to be one key system for the endogenous modulation of pain. Furthermore, recent findings from functional and anatomical neuroimaging support the notion that an altered interaction of pro- and anti-nociceptive mechanisms may contribute to the development or maintenance of chronic pain states. Research on the involved circuitry and implemented mechanisms is a major focus of contemporary neuroscientific research in the field of pain and should provide new insights to prevent and treat chronic pain states.

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“…Nociceptive stimuli do not only integrate temporally, but also spatially (Quevedo and Coghill, 2007). Spatial summation is an increase in pain intensity when the size of the stimulated area is expanded, e.g.…”

Section: Spatial Summationmentioning

confidence: 99%

Assessment and manifestation of central sensitisation across different chronic pain conditions

Arendt-Nielsen

Morlion

Perrot

et al. 2017

European Journal of Pain

517

494

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Different neuroplastic processes can occur along the nociceptive pathways and may be important in the transition from acute to chronic pain and for diagnosis and development of optimal management strategies. The neuroplastic processes may result in gain (sensitisation) or loss (desensitisation) of function in relation to the incoming nociceptive signals. Such processes play important roles in chronic pain, and although the clinical manifestations differ across condition processes, they share some common mechanistic features. The fundamental understanding and quantitative assessment of particularly some of the central sensitisation mechanisms can be translated from preclinical studies into the clinic. The clinical perspectives are implementation of such novel information into diagnostics, mechanistic phenotyping, prevention, personalised treatment, and drug development. The aims of this paper are to introduce and discuss (1) some common fundamental central pain mechanisms, (2) how they may translate into the clinical signs and symptoms across different chronic pain conditions, (3) how to evaluate gain and loss of function using quantitative pain assessment tools, and (4) the implications for optimising prevention and management of pain. The chronic pain conditions selected for the paper are neuropathic pain in general, musculoskeletal pain (chronic low back pain and osteoarthritic pain in particular), and visceral pain (irritable bowel syndrome in particular). The translational mechanisms addressed are local and widespread sensitisation, central summation, and descending pain modulation. Significance Central sensitisation is an important manifestation involved in many different chronic pain conditions. Central sensitisation can be different to assess and evaluate as the manifestations vary from pain condition to pain condition. Understanding central sensitisation may promote better profiling and diagnosis of pain patients and development of new regimes for mechanism based therapy. Some of the mechanisms underlying central sensitisation can be translated from animals to humans providing new options in development of therapies and profiling drugs under development.

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Attentional Modulation of Spatial Integration of Pain: Evidence for Dynamic Spatial Tuning

Cited by 78 publications

References 50 publications

Social stress exacerbates the aversion to painful experiences in rats exposed to chronic pain: The role of the locus coeruleus

Social stress exacerbates the aversion to painful experiences in rats exposed to chronic pain: The role of the locus coeruleus

Imaging CNS Modulation of Pain in Humans

Assessment and manifestation of central sensitisation across different chronic pain conditions

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