Learning can be considered a function of synthesis in which both cognitive functioning and the domain of affectivity convey. The aim of the present study was to investigate how specific literacy skills, i.e., reading and writing, relate to two main dimensions of negative affectivity, i.e., anxiety and depression. Study 1 was conducted on third grade children (72), while Study 2 focused on first grade children (43). Two groups of participants selected because they had been deemed 'at risk' for the development of anxiety or depression and a control group were compared in reading and writing tasks, which included both word and non-word lists. The assessment included also the evaluation of Verbal, Nonverbal and Composite IQs. Results indicated that children 'at risk' for depression made more spelling errors in dictation of words in comparison to the control group. No differences emerged in reading tasks or with reference to the group of children 'at risk' for anxiety.School learning is a complex process. Although it is based on specific cognitive competences, it develops in interaction with other factors, for example learning contexts, personal experience, social competences and affective development. Greater attention to the relationship between emotional and cognitive states might allow for a more in-depth knowledge of the learning process and of the factors that can hinder its development, making it possible to lessen the gap between cognitive and affective research areas which have remained in opposition for too (Stein & Young, 1992).