Attenuated brain derived neurotrophic factor and depression in type 2 diabetes mellitus patients: A case-control study

Parveen, Rizwana; Kapur, Prem; Kohli, Sunil; Agarwal, Nidhi

doi:10.1016/j.cegh.2022.101016

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…Decreased grip strength, commonly used as a surrogate for weaker muscle strength (Bohannon, 2015), is associated with depressive symptoms in cross-sectional and longitudinal studies among middle-aged and older adults (Ashdown-Franks et al, 2019;Fukumori et al, 2015;Marques et al, 2021). Decreased serum BDNF levels have been associated with depression in persons with type 2 diabetes (Parveen et al, 2022). Myocytes can synthesize and release several myokines, including BDNF, to the blood flow after muscle contractions (J. H. Lee & Jun, 2019).…”

Section: Introductionmentioning

confidence: 99%

The Influence of the BDNF Val66Met Variant on the Association Between Physical Activity/Grip Strength and Depressive Symptoms in Persons With Diabetes

et al. 2022

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The rs6265 in the brain-derived neurotrophic factor (BDNF) is associated with depression in people with diabetes. Both physical activity (PA) and grip strength are negatively associated with depression. We conducted cross-sectional analyses of the wave 10 survey data for a nationally representative sample of 1,051 diabetes participants of the Health and Retirement Study. Both greater PA (β = −.15) and stronger grip strength (β = −.02) were independently associated with depression. Although the interaction between BDNF rs6265 and PA on depressive symptoms was not significant, the negative PA-depression association was stronger among female non-Met carriers (β = −.19) and male Met carriers (β = −.14). Meanwhile, grip strength was associated with depression only in Met carriers (β = −.04), and similar association was observed in both males and females. In conclusion, female non-Met carriers and male Met carriers may benefit from PA, and Met carriers may benefit from grip strength to relieve depression.

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Section: Introductionmentioning

confidence: 99%

The Influence of the BDNF Val66Met Variant on the Association Between Physical Activity/Grip Strength and Depressive Symptoms in Persons With Diabetes

et al. 2022

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“…Most of the studies have found reduced BDNF levels, both in diabetic animals and human patients, in a correlation with the intensity of memory decline, suggesting the important contribution of BDNF in the pathophysiology of cognitive impairment [97,[160][161][162][163][164][165]. Furthermore, the prevalence of depression is higher in diabetic patients, with a more prominent decrease in serum BDNF levels [166]. The relationship between fasting blood glucose and BDNF levels is not so clear-cut, as results indicating both a positive correlation [167] and no correlation [168] have been reported.…”

Section: Other Factors Contributing To Cognitive Dysfunction In Diabe...mentioning

confidence: 99%

Flavonols as a Potential Pharmacological Intervention for Alleviating Cognitive Decline in Diabetes: Evidence from Preclinical Studies

Horvat,

Vlašić,

Štefulj

et al. 2023

Life

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Diabetes mellitus is a complex metabolic disease associated with reduced synaptic plasticity, atrophy of the hippocampus, and cognitive decline. Cognitive impairment results from several pathological mechanisms, including increased levels of advanced glycation end products (AGEs) and their receptors, prolonged oxidative stress and impaired activity of endogenous mechanisms of antioxidant defense, neuroinflammation driven by the nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB), decreased expression of brain-derived neurotrophic factor (BDNF), and disturbance of signaling pathways involved in neuronal survival and cognitive functioning. There is increasing evidence that dietary interventions can reduce the risk of various diabetic complications. In this context, flavonols, a highly abundant class of flavonoids in the human diet, are appreciated as a potential pharmacological intervention against cognitive decline in diabetes. In preclinical studies, flavonols have shown neuroprotective, antioxidative, anti-inflammatory, and memory-enhancing properties based on their ability to regulate glucose levels, attenuate oxidative stress and inflammation, promote the expression of neurotrophic factors, and regulate signaling pathways. The present review gives an overview of the molecular mechanisms involved in diabetes-induced cognitive dysfunctions and the results of preclinical studies showing that flavonols have the ability to alleviate cognitive impairment. Although the results from animal studies are promising, clinical and epidemiological studies are still needed to advance our knowledge on the potential of flavonols to improve cognitive decline in diabetic patients.

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Etiopathogenesis and management updates on the comorbidity depression – Diabetes: A review of literature

Muyisa Muhindo

2025

Endocrine and Metabolic Science

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Attenuated brain derived neurotrophic factor and depression in type 2 diabetes mellitus patients: A case-control study

Cited by 4 publications

References 31 publications

The Influence of the BDNF Val66Met Variant on the Association Between Physical Activity/Grip Strength and Depressive Symptoms in Persons With Diabetes

The Influence of the BDNF Val66Met Variant on the Association Between Physical Activity/Grip Strength and Depressive Symptoms in Persons With Diabetes

Flavonols as a Potential Pharmacological Intervention for Alleviating Cognitive Decline in Diabetes: Evidence from Preclinical Studies

Etiopathogenesis and management updates on the comorbidity depression – Diabetes: A review of literature

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