Attenuated <i>Bordetella pertussis </i><scp>BPZE</scp>1 protects against allergic airway inflammation and contact dermatitis in mouse models

Li, R.; Chang, Cheng; Chong, Shu Zhen; Lim, Annabelle; Goh, Y. F.; Locht, Camille; Kemeny, David M.; Angeli, Véronique; Wong, W.S. Fred; Alonso, Sylvie

doi:10.1111/j.1398-9995.2012.02884.x

Cited by 21 publications

(14 citation statements)

References 35 publications

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“…It is now well established that exposure to microorganisms is an important factor in shaping the immune system and also is important for the susceptibility to develop allergies and asthma (26). This holds true for the exposure to exogenous bacteria, and different research groups have shown that exposure to bacteria prior to or starting at the time of sensitization reduces the development of allergic disease in various models (27)(28)(29)(30). There is also increasing evidence that microbiota contribute to the susceptibility to develop an allergic disease, and changes in the composition of the microbiota have been linked to the increased prevalence of allergies and asthma (31,32).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease

Wijck

Kleijn

John-Schuster

et al. 2018

The Journal of Immunology

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Epidemiological and experimental studies have shown that exposure to the gastric bacterium , especially in early life, prevents the development of asthma. Recent mouse studies have shown that this protective effect does not require live bacteria and that treatment with an extract of in neonates prevents the development of airway inflammation and goblet cell metaplasia. In the current study, the effect of administration of an extract of was assessed in a therapeutic study design with application of the extract just prior to allergen challenge. C57BL/6 mice were sensitized and challenged with OVA or house dust mite. Treatment with extract just prior to the challenge significantly reduced airway inflammation, as assessed in bronchoalveolar lavage fluid and lung tissue, and reduced airway remodeling, as assessed by goblet cell quantification. These effects were apparent in the OVA model and in the house dust mite model. Injection of extract reduced the processing of allergen by dendritic cells in the lungs and mediastinal lymph node. Bone marrow-derived dendritic cells exposed to extract were affected with regard to their ability to process Ag. These data show that application of extract after sensitization effectively inhibits allergic airway disease.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease

Wijck

Kleijn

John-Schuster

et al. 2018

The Journal of Immunology

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“…The use of an attenuated B. pertussis strain administered intranasally has been successfully tested in animal models and moved to Phase I clinical trials. 39,40 Although this is a promising application that has shown some advantages, 41,42 it shares the potential safety concerns related to the use of attenuated pathogens. 39 An interesting alternative that combines some of the above-mentioned strategies is the use of outer membrane vesicles, also called nanoparticles, which contain bacterial surface antigens.…”

Section: Development Of Improved Pertussis Vaccinementioning

confidence: 99%

Development of improved pertussis vaccine

Rumbo

Hozbor

2014

Human Vaccines & Immunotherapeutics

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“…Mice were euthanized 48 h after the last aerosolized OVA challenge (day 26), and bronchoalveolar lavage fluids (BALFs) were collected as previously reported method [68]. Briefly, after euthanasia, tracheotomy was carried out and an arteriovenous indwelling needle (20G; BRAUN, Germany) was inserted .…”

Section: Bronchoalveolar Lavage Collection and Cell Countingmentioning

confidence: 99%

Allergen specific Treg upregulated by lung-stage schistosome infection alleviates allergic airway inflammation via inhibiting IgE secretion

Zhang

Luo

et al. 2020

Preprint

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Schistosome infection showed protective effects against allergic airway inflammation (AAI). However,controversial findings exist especially regarding the timing of helminth infection and the underlying mechanisms. Moreover, most previous studies focused on understanding the preventive effect of schistosome infection on asthma (infection before allergen sensitization), while its therapeutic effects (infection after allergen sensitization) were rarely investigated. In this study, we investigated the therapeutic effects of schistosome infection on AAI using a mouse model of OVA induced asthma. To explore how the timing of schistosome infection influences its therapeutic effect, the mice were percutaneously infected with cercaria of Schistosoma japonicum at either 1 day before OVA induced asthma attack (infection at lung-stage during AAI) or 14 days before OVA induced asthma attack (infection at post lung-stage during AAI). We found that lung-stage schistosome infection significantly ameliorated OVA-induced AAI, whereas post lung-stage infection showed no therapeutic effect. Mechanistically, the lung-stage schistosome infection significantly upregulated the frequency of Treg, especially OVA specific Treg, in lung tissue, which negatively correlated with the level of OVA specific IgE. Depletion of Treg in vivo counteracted the therapeutic effect. Furthermore, transcriptomic analysis of lung tissue showed that lung-stage schistosome infection during AAI shaped the microenvironment to favor Treg induction. In conclusion, our data showed that lung-stage schistosome infection could relieve OVA induced asthma in a mouse model. The therapeutic effect was mediated by the upregulated OVA specific Treg which suppressed IgE production and Th2 cytokine secretion. Our results may facilitate the discovery of a new therapy for AAI.

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Attenuated Bordetella pertussis BPZE1 protects against allergic airway inflammation and contact dermatitis in mouse models

Abstract: Our study demonstrates the broad anti-inflammatory properties of the attenuated B. pertussis BPZE1 vaccine candidate and supports its development as a promising agent to prevent and/or treat allergic diseases.

Cited by 21 publications

References 35 publications

Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease

Therapeutic Application of an Extract of Helicobacter pylori Ameliorates the Development of Allergic Airway Disease

Development of improved pertussis vaccine

Allergen specific Treg upregulated by lung-stage schistosome infection alleviates allergic airway inflammation via inhibiting IgE secretion

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