Attenuated mTOR Signaling and Enhanced Glucose Homeostasis by Dietary Supplementation with Lotus Seedpod Oligomeric Procyanidins in Streptozotocin (STZ)-Induced Diabetic Mice

Li, Xiaopeng; Sui, Yong; Wu, Qian; Xie, Bijun; Sun, Zhida

doi:10.1021/acs.jafc.7b00233

Cited by 42 publications

(37 citation statements)

References 66 publications

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“…This plant-based bioactive agent has previously been shown to exhibit a variety of beneficial health effects. In vivo and in vitro studies have demonstrated that it has hypolipidemia, hypoglycemic activity, and the ability to inhibit cognitive impairment [6][7][8][9]. Furthermore, Duan et al [10] reported that procyanidins from lotus had significant growth inhibition effects on mouse melanoma B16 both in vivo (inhibiting tumor growth in C57BL/6 J mice by 55.3% in terms of average tumor weight) and in vitro (possessing cytotoxicity against mouse melanoma B16 cell line).…”

Section: Introductionmentioning

confidence: 99%

Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage

et al. 2020

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The potential protective effect of nanoliposomes loaded with lotus seedpod oligomeric procyanidin (LSOPC) against melanogenesis and skin damaging was investigated. Fluorescence spectroscopy showed that, after encapsulation, the LSOPC-nanoliposomes still possessed strong inhibitory effects against melanogenesis, reducing the activity of both monophenolase and diphenolase. Molecular docking indicated that LSOPC could generate intense interactive configuration with tyrosinase through arene–H, arene–arene, and hydrophobic interaction. An ultraviolet radiated cell-culture model (human foreskin fibroblast cell (HFF-1)) was used to determine the protective effects of the LSOPC-nanoliposomes against skin aging and damage. Results showed that LSOPC-nanoliposomes exerted the highest protective effects against both ultraviolet B (UVB) and ultraviolet A (UVA) irradiation groups compared with non-encapsulated LSOPC and a control (vitamin C). Superoxide dismutase (SOD) and malonaldehyde (MDA) assays demonstrated the protection mechanism may be related to the anti-photooxidation activity of the procyanidin. Furthermore, a hydroxyproline assay suggested that the LSOPC-nanoliposomes had a strong protective effect against collagen degradation and/or synthesis after UVA irradiation.

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Section: Introductionmentioning

confidence: 99%

Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage

et al. 2020

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“…LLSPCs have far‐ranging pharmacological actions. LSPCs may restrain oxidative stress injury , reverse hippocampal neuronal cell death induced by extremely low‐frequency electromagnetic fields exposure in mice , modulate glucose disposal in peripheral target tissues of streptozotocin‐induced diabetic mice , defend against nonalcoholic fatty liver disease in Sprague‐Dawley male rats , prohibit the formation of advanced glycation end product, has a powerful whole body radioprotective activity , and ameliorative cognitive deficits in aged impaired animals . In the present study, LSPC treatment reduced walking time and forelimb lifting‐up frequency, cerebral levels ADMA, noradrenaline, and glutamic acid; augmented total sleep time, cerebral 5‐hydroxytryptamine concentration, and cerebral γ‐aminobutyric acid concentration concomitantly with elevated cerebral expressions of DDAH‐1, DDAH2, and nNOS in insomniac rats.…”

Section: Discussionmentioning

confidence: 99%

“…In order to establish insomniac rat models, p‐chlorophenylalanine (300 mg/kg body weight) were intraperitoneally injected into the rats in the morning of each day for two consecutive days. LSPC was dissolved in physiological saline as described previously . Normal rat and untreated insomniac rat were treated with vehicle of LSPC.…”

Section: Methodsmentioning

confidence: 99%

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Procyanidin B2 from lotus seedpod regulate NO/ADMA/DDAH pathway to treat insomnia in rats

Wang

Liang

et al. 2019

Fundamemntal Clinical Pharma

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Recent studies show that nitric oxide/asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase (NO/ADMA/DDAH) pathway may contribute to the development of sleep disorder. The objective of this study was to explore the inhibitory effect of procyanidin B2 from lotus seedpod (LSPC), a naturally occurring catechin compound, on insomnia and the mechanisms involved. The experiments were performed in brain from Sprague‐Dawley rat control and insomniac rats treated or not with LSPC (15, 30, and 45 mg/kg, intragastrically) for 7 days. LSPC treatment reduced walking time and forelimb lifting‐up frequency, cerebral levels of noradrenaline, glutamic acid, ADMA, sleep latency, and 8‐isoprostane; increased sleep duration, cerebral concentrations of 5‐hydroxytryptamine, γ‐aminobutyric acid, and NO concomitantly with upregulated cerebral expression of DDAH 1, DDAH2, and neuronal NO synthases in insomniac rats. The present results suggest that LSPC may regulate NO/ADMA/DDAH pathway by inhibiting oxidative stress to treat insomnia in rats when sleep evaluation was achieved on the basis of behavioral criteria.

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“…It has been reported that lotus seedpod is rich in polyphenols and an important natural source of oligomers and polymers of catechin, which are also denominated procyanidins [19,20]. In recent years, procyanidins from lotus seedpod have been shown to possess antioxidant, anti-aging, anti-memory impairment, radioprotective, anti-glycative, and anti-inflammatory activities [20][21][22][23][24][25]. However, little information is available on the anti-lipid accumulation and anti-lipotoxic effect of lotus seedpod extract (LSE) in hepatocytes.…”

Section: Introductionmentioning

confidence: 99%

Lotus Seedpod Extracts Reduced Lipid Accumulation and Lipotoxicity in Hepatocytes

et al. 2019

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Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic disorders, including hepatic lipid accumulation and lipotoxicity. Plant-derived polyphenols have attracted considerable attention in the prevention of NAFLD. Lotus seedpod, rich in polyphenols, is a traditional Chinese herbal medicine. Previous studies have showed that lotus seedpod possess radioprotective, antioxidant, anti-cancer, and anti-inflammatory activities. In this study, the in vitro hepatoprotective effect of lotus seedpod extract (LSE) and its main component epigallocatechin (EGC) was examined. Firstly, oleic acid (OA), an unsaturated fatty acid, was used to induce the phenotype of NAFLD in human hepatocytes, HepG2 cells. LSE dose-dependently improved the OA-induced viability loss of HepG2 cells. Non-cytotoxic concentrations of LSE or EGC abolished intracellular lipid accumulation and oxidative stress in the OA-treated cells. In addition, LSE and EGC showed a minor effect on autophagy, and potential in reducing OA-induced occurrence of apoptosis confirmed by morphological and biochemical features, including an increase in the formation of apoptotic bodies, the exposure of phosphatidylserine, and activation of caspases. Molecular data showed the anti-apoptotic effect of LSE might be mediated via downregulation of the mitochondrial pathway. Our data imply that EGC-enriched LSE potentially could be developed as an anti-NAFLD agent.

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Attenuated mTOR Signaling and Enhanced Glucose Homeostasis by Dietary Supplementation with Lotus Seedpod Oligomeric Procyanidins in Streptozotocin (STZ)-Induced Diabetic Mice

Cited by 42 publications

References 66 publications

Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage

Oligomeric Procyanidin Nanoliposomes Prevent Melanogenesis and UV Radiation-Induced Skin Epithelial Cell (HFF-1) Damage

Procyanidin B2 from lotus seedpod regulate NO/ADMA/DDAH pathway to treat insomnia in rats

Lotus Seedpod Extracts Reduced Lipid Accumulation and Lipotoxicity in Hepatocytes

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