Attenuated neuronal and autonomic responses during error processing in anorexia nervosa

Abstract

contributed equally to this study.

Neural Correlates of Executive Functioning in Anorexia Nervosa and Obsessive–Compulsive Disorder

“…Individuals with AN present with reduced gray matter in the ACC, which is related to severity of the disorder as measured by BMI ( Mühlau et al, 2007 ). fMRI studies have produced conflicting findings, as elevated ACC activity has been reported in one study with female adolescents who have a diagnosis of AN ( Geisler et al, 2017 ), whilst others report no difference in ACC activity in individuals who have either recovered from AN or have a current diagnosis, compared to HCs ( Wierenga et al, 2014 ; Ritschel et al, 2017 ; Suttkus et al, 2021 ). It is worth highlighting that none of these studies used a Flanker task in their designs, instead a probabilistic reversal learning task ( Geisler et al, 2017 ; Ritschel et al, 2017 ), Stop-signal task ( Wierenga et al, 2014 ), and Go/NoGo task ( Suttkus et al, 2021 ) were employed.…”

“…Compared to OCD, fewer studies have examined response inhibition in AN. Overall, studies either report impairments in response inhibition, including increased error rates and longer reaction times compared to HCs ( Galimberti et al, 2012 ; Collantoni et al, 2016 ), or no differences between individuals with AN and HCs (e.g., Oberndorfer et al, 2011 ; Wierenga et al, 2014 ; Yue et al, 2020 ; Suttkus et al, 2021 ). Response inhibition impairments appear to be more pertinent for individuals with AN-BP eating behaviors ( Galimberti et al, 2012 ), whilst adolescents with AN-R demonstrate enhanced response inhibition compared to HCs ( Weinbach et al, 2020 ).…”

“…Compared to OCD, studies exploring the role of response monitoring in AN are mixed. A few studies report no differences in behavioral performance between individuals with AN and HCs ( Wierenga et al, 2014 ; Geisler et al, 2017 ; Suttkus et al, 2021 ) and others providing some indicators of poorer ( Ritschel et al, 2017 ) or better performance ( Pieters et al, 2007 ) in individuals with AN. For example, compared to HCs on a flanker task, individuals with AN made fewer errors overall and were less likely to follow an error with another incorrect response ( Pieters et al, 2007 ).…”