Attenuated RANKL-induced cytotoxicity by Portulaca oleracea ethanol extract enhances RANKL-mediated osteoclastogenesis

Erkhembaatar, Munkhsoyol; Choi, Eun Jung; Lee, Hak-Yong; Lee, Choong Hun; Lee, Young‐Rae; Kim, Min Seuk

doi:10.1186/s12906-015-0770-9

Cited by 3 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to current studies, two MFH plants were only tested on RANKL-induced osteoclastogenesis processes in vitro : both C. album and Z. schinifolium were tested on the RANKL-induced RAW 264.7 cell line [ 17 ]. The two MFH plant extracts from purslane [ 15 ] and A. officinarum [ 31 ] and the polysaccharide from P. sibiricum [ 25 , 27 ] were also tested on RANKL-induced osteoclastogenesis processes on primary bone marrow-derived macrophages (BMMs).…”

Section: In Vitro Studiesmentioning

confidence: 99%

Antiosteoporosis Studies of 20 Medicine Food Homology Plants Containing Quercetin, Rutin, and Kaempferol: TCM Characteristics, In Vivo and In Vitro Activities, Potential Mechanisms, and Food Functions

Shen

Feng

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Dietary nutraceutical compounds have been evidenced as backbone for bone health in recent years. It is reported that medicine food homology (MFH) plants have multiple nutraceutical compounds. Based on our literature research, 20 MFH plants caught our attention because they contain three popular antiosteoporosis compounds simultaneously: quercetin, rutin, and kaempferol. According to traditional Chinese medicine (TCM), their characteristics including natures, flavors, attributive to meridian tropism, and efficacies were listed. The relationships between TCM efficacies, such as “heat clearing,” “tonic,” and “the interior warming,” and antiosteoporosis pharmacological actions such as antioxidant and immune regulation were discussed. The in vivo antiosteoporosis effects of the 20 MFH plants were summarized. The in vitro antiosteoporosis activities and related mechanisms of the 20 plants and quercetin, rutin, kaempferol were detailed. The TGF-β-Smad signaling, fibroblast growth factor, and Wnt/β-catenin signaling on bone formation and the RANKL signaling, NF-κB signaling, and macrophage-colony-stimulating factor on bone resorption were identified. From food point, these 20 MFH plants could be classified as condiment, vegetable, fruit, tea and related products, beverage, etc. Based on the above discussion, these 20 MFH plants could be used as daily food supplements for the prevention and treatment against osteoporosis.

show abstract

Section: In Vitro Studiesmentioning

confidence: 99%

Antiosteoporosis Studies of 20 Medicine Food Homology Plants Containing Quercetin, Rutin, and Kaempferol: TCM Characteristics, In Vivo and In Vitro Activities, Potential Mechanisms, and Food Functions

Shen

Feng

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…The POEE inhibits RANKL-induced [Ca 2+ ] i oscillations and NFATc1 activation, while it enhances RANKL-induced osteoclast differentiation by reducing RANKL-mediated cytotoxicity. Erkhembaatar et al [84] proposed that RANKL-mediated cytotoxicity due to Ca 2+ release from intracellular Ca 2+ stores is attenuated by POEE, which leads to enhanced RANKL-induced osteoclast differentiation.…”

Section: Portulaca Oleraceamentioning

confidence: 99%

The Role of Ca2+-NFATc1 Signaling and Its Modulation on Osteoclastogenesis

Kang

Yang

et al. 2020

IJMS

View full text Add to dashboard Cite

The increasing of intracellular calcium concentration is a fundamental process for mediating osteoclastogenesis, which is involved in osteoclastic bone resorption. Cytosolic calcium binds to calmodulin and subsequently activates calcineurin, leading to NFATc1 activation, a master transcription factor required for osteoclast differentiation. Targeting the various activation processes in osteoclastogenesis provides various therapeutic strategies for bone loss. Diverse compounds that modulate calcium signaling have been applied to regulate osteoclast differentiation and, subsequently, attenuate bone loss. Thus, in this review, we summarized the modulation of the NFATc1 pathway through various compounds that regulate calcium signaling and the calcium influx machinery. Furthermore, we addressed the involvement of transient receptor potential channels in osteoclastogenesis.

show abstract

Nutritional values, bioactive compounds and health benefits of purslane ( Portulaca oleracea L.): a comprehensive review

Li,

Xiao,

Yan

et al. 2024

Food Science and Human Wellness

View full text Add to dashboard Cite

Portulaca oleracea L., commonly known as purslane, is a worldwide weed species belonging to the family Portulacaceae and has been known as "Global Panacea". As one of the most widely consumed green vegetable and medicinal plants around the world, it has recently been re-evaluated as a potential "new crop" due to the properties that differentiate it as one of the best vegetable sources of omega-3 fatty acid (α-linolenic acid), as well as a variety of nutrients and phytochemicals. Accordingly, emerging research has found that purslane exhibits health-promoting properties like anti-inflammatory, anti-hyperglycemic, antioxidant, neuroprotective, and immunomodulatory. These findings suggest that this species possesses a potential using as a dietary supplement beyond potherb and traditional medicine. This review systematically summarizes the up-to-date research carried out on purslane, which includes the nutritional compositions, bioactive compounds, and health benefits it exerts as well as limitations, challenges, and future directions of research. Finally, we hope that this review would provide purslane with a comprehensive reference and future scope as functional and health-promoting food for disease prevention and treatment.

show abstract

Attenuated RANKL-induced cytotoxicity by Portulaca oleracea ethanol extract enhances RANKL-mediated osteoclastogenesis

Cited by 3 publications

References 18 publications

Antiosteoporosis Studies of 20 Medicine Food Homology Plants Containing Quercetin, Rutin, and Kaempferol: TCM Characteristics, In Vivo and In Vitro Activities, Potential Mechanisms, and Food Functions

Antiosteoporosis Studies of 20 Medicine Food Homology Plants Containing Quercetin, Rutin, and Kaempferol: TCM Characteristics, In Vivo and In Vitro Activities, Potential Mechanisms, and Food Functions

The Role of Ca2+-NFATc1 Signaling and Its Modulation on Osteoclastogenesis

Nutritional values, bioactive compounds and health benefits of purslane ( Portulaca oleracea L.): a comprehensive review

Contact Info

Product

Resources

About