Attenuating effect of Polygala tenuifolia Willd. seed oil on progression of MAFLD

Xin, Meiling; Wang, Hanlin; Wang, Meng; Yang, Bendong; Liang, Shufei; Xu, Xiaoxue; Dong, Ling; Cai, Tianqi; Huang, Yuhong; Wang, Qing; Wang, Chao; Cui, Yuting; Xu, Zhengbao; Sun, Wenlong; Song, Xinhua; Sun, Jinyue

doi:10.3389/fphar.2023.1253715

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…P. tenuifolia seed oil (PWSO) therapeutic diet (17% lard and 14% PWSO diet) inactivates SREBP1 and SREBP2, which are involved in lipogenesis, to attenuate hepatic lipid accumulation and reduce inflammatory responses induced through the NF-κB signaling pathway. Studies have shown that PWSO can be a relatively effective dietary supplement to inhibit the onset and progression of MAFLD ( 79 ).…”

Section: Lifestyle Interventions Of Mafldmentioning

confidence: 99%

Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

Chen,

Qin,

Jiang

et al. 2024

Front. Nutr.

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MAFLD has become a major global health problem and is the leading cause of liver disease worldwide. The disease progresses from a simple fatty liver to gradual fibrosis, which progresses to cirrhosis and even hepatocellular liver cancer. However, the methods currently used for diagnosis are invasive and do not facilitate clinical assessment of the condition. As a result, research on markers for the diagnosis of MAFLD is increasing. In addition, there are no clinical medications for the treatment of MAFLD, and lifestyle interventions remain effective in the prevention and treatment of MAFLD. In this review, we attempt to make a summary of the emerging diagnostic indicators and effective lifestyle interventions for MAFLD and to provide new insights into the diagnosis and treatment of MAFLD.

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Section: Lifestyle Interventions Of Mafldmentioning

confidence: 99%

Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

Chen,

Qin,

Jiang

et al. 2024

Front. Nutr.

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A review of the botany, metabolites, pharmacology, toxicity, industrial applications, and processing of Polygalae Radix: the “key medicine for nourishing life”

Kuang,

Kong,

Hou

et al. 2024

Front. Pharmacol.

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Polygalae radix (PR) is the dried root of Polygala tenuifolia Willd. and Polygala sibirica L. and enjoys the reputation as the “key medicine for nourishing life.” In this study, information about “Polygala tenuifolia Willd.,” “Polygala sibirica L.,” and “Yuanzhi” was retrieved from scientific databases, including Google Scholar, Baidu Scholar, Web of Science, PubMed, CNKI, and Wan Fang Data. Information from Chinese herbal medicine classics, Yaozhi Data, and the Gaide Chemical Network was also collected. Information related to botany, phytochemistry, pharmacology, toxicity, industrial applications, and processing is summarized in this paper to tap its potentialities and promote its further development and clinical application. More than 320 metabolites have been isolated from PR; saponins, xanthones, and oligosaccharide esters are the main functional metabolites. Pharmacological research shows that its pharmacological action mainly focuses on resisting nervous system diseases, and it also has the functions of anti-oxidation, anti-inflammation, anti-tumor, anti-pathogenic microorganisms and others. The gastrointestinal irritation of its saponins impeded its application, but this irritation can be reduced by controlling the dosage, compatibility with other herbs, or processing. The future progress of PR faces opportunities and challenges. More attention should be paid to the traditional application and processing methods of PR recorded in ancient books. The lack of safety and clinical studies has limited its application and transformation of achievements. Moreover, it is one-sided to take the content of only a few metabolites as the index of processing optimization and quality control, which cannot reflect the full pharmacological and toxicological activities of PR.

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Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

Tauil,

Golono,

de Lima

et al. 2024

Pharmaceuticals

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Metabolic-Associated Fatty Liver Disease (MAFLD) is a clinical–pathological scenario that occurs due to the accumulation of triglycerides in hepatocytes which is considered a significant cause of liver conditions and contributes to an increased risk of death worldwide. Even though the possible causes of MAFLD can involve the interaction of genetics, hormones, and nutrition, lifestyle (diet and sedentary lifestyle) is the most influential factor in developing this condition. Polyphenols comprise many natural chemical compounds that can be helpful in managing metabolic diseases. Therefore, the aim of this review was to investigate the impact of oxidative stress, inflammation, mitochondrial dysfunction, and the role of polyphenols in managing MAFLD. Some polyphenols can reverse part of the liver damage related to inflammation, oxidative stress, or mitochondrial dysfunction, and among them are anthocyanin, baicalin, catechin, curcumin, chlorogenic acid, didymin, epigallocatechin-3-gallate, luteolin, mangiferin, puerarin, punicalagin, resveratrol, and silymarin. These compounds have actions in reducing plasma liver enzymes, body mass index, waist circumference, adipose visceral indices, lipids, glycated hemoglobin, insulin resistance, and the HOMA index. They also reduce nuclear factor-KB (NF-KB), interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), blood pressure, liver fat content, steatosis index, and fibrosis. On the other hand, they can improve HDL-c, adiponectin levels, and fibrogenesis markers. These results show that polyphenols are promising in the prevention and treatment of MAFLD.

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Attenuating effect of Polygala tenuifolia Willd. seed oil on progression of MAFLD

Cited by 3 publications

References 32 publications

Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

Diagnostic indicators and lifestyle interventions of metabolic-associated fatty liver disease

A review of the botany, metabolites, pharmacology, toxicity, industrial applications, and processing of Polygalae Radix: the “key medicine for nourishing life”

Metabolic-Associated Fatty Liver Disease: The Influence of Oxidative Stress, Inflammation, Mitochondrial Dysfunctions, and the Role of Polyphenols

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