Attenuating UVA-induced oxidative stress of human skin fibroblasts by enhancing bioactive components of Armillaria luteo-virens by Lactobacillus delbrueckii subsp. Bulgaricus fermentation

Zhao, Jingsha; You, Shiquan; Wang, Dongdong; Su, Ning; Li, Yang; Zhao, Dan; Zhang, Jiachan; Li, Meng; Wang, Changtao

doi:10.1016/j.fbio.2023.102899

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…When exposed to UVA radiation, the MAPK pathway is activated by the phosphorylation of the ERK, JNK, and p38 proteins, and gene expression is up-regulated. c-Fos and c-Jun activities are activated upon phosphorylation of the MAPK pathway, further upregulating MAPK transcription (Zhao et al 2023 ). In this study, the model group underwent UVA radiation, the MAPK pathway was phosphorylated, and the mRNA expression levels of related genes were elevated compared with the blank group, in which the overexpression of c-Fos and c-Jun induced the transcription of MMPs, which led to cellular damage and photoaging.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells

Wang,

Zhang,

Wang

et al. 2023

Bioresour. Bioprocess.

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Background Aureobasidium pullulans (A. pullulans) has a wide range of applications. Ultraviolet (UV) rays from the sun can cause skin photoaging. In order to explore the protective effect and application potential of A. pullulans lysate on UV-damaged human skin fibroblasts (HSF) and HaCaT Cells, this study investigates the anti-aging and anti-inflammatory effects of A. pullulans lysate as well as the mechanism of anti-oxidative stress at the cellular and molecular levels through cytotoxicity experiments, enzyme-linked immunosorbent assays (ELISA), and real-time quantitative PCR (RT-qPCR). Results The experimental results have shown that the A. pullulans lysate can effectively reduce the loss of extracellular matrix components (EMC), such as collagen and hyaluronic acid (HA). It is also capable of scavenging excess reactive oxygen species (ROS) from the body, thereby increasing the activity of catalase, decreasing the overexpression of intracellular matrix metalloproteinases (MMPs), enhancing the gene expression of metalloproteinase inhibitors (TIMPs), and decreasing the level of inflammatory factors, reducing UV-induced apoptosis of HaCaT cells. Meanwhile, oxidative stress homeostasis is also regulated through the Nrf2/Keap1 and MAPK signaling pathways. Conclusions This study shows that the A. pullulans lysate has the potential to resist photoaging. Graphical Abstract

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Section: Discussionmentioning

confidence: 99%

Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells

Wang,

Zhang,

Wang

et al. 2023

Bioresour. Bioprocess.

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Comparison and Assessment of Anti‐Inflammatory and Antioxidant Capacity Between EGCG and Phosphatidylcholine‐Encapsulated EGCG

Yuan,

Hu,

Zhu

et al. 2024

J of Cosmetic Dermatology

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AimTo compare and evaluate the differences between EGCG and phosphatidylcholine‐encapsulated EGCG in terms of their anti‐inflammatory and antioxidant capacities.MethodsIn this study, transdermal absorption experiments were conducted to compare the absorption capacity of EGCG and phosphatidylcholine‐encapsulated EGCG. Subsequently, the disparity in anti‐inflammatory and antioxidant efficacy between EGCG and phosphatidylcholine‐encapsulated EGCG were evaluated through cytotoxicity experiments, as well as the determination of cellular inflammatory factors and the measurement of ROS content under different treatment conditions.ResultsThe concentration of EGCG, encapsulated in phosphatidylcholine, in porcine skin is 40.76 ± 1.29 μg/cm2, which is significantly higher than the concentration of EGCG alone (31.62 ± 2.01 μg/cm2). Also, the ability of phosphatidylcholine‐encapsulated EGCG to suppress inflammatory factors such as tumor necrosis factor‐α (TNF‐α), cyclooxygenase‐2 (COX‐2), and prostaglandin E2 (PGE2) was notably superior to that of EGCG alone. Both phosphatidylcholine‐encapsulated EGCG and EGCG showed excellent ROS scavenging ability in terms of antioxidant capacity.ConclusionThe percutaneous absorption and anti‐inflammatory impact of EGCG encapsulated within phosphatidylcholine were substantially enhanced when compared to EGCG by itself. Additionally, both formulations exhibited enhanced ROS scavenging capacities, albeit the variance between them was not pronounced. These insights furnish a vital theoretical underpinning for the utilization of phosphatidylcholine‐encapsulated EGCG in cosmetic applications, specifically for fostering products with anti‐inflammatory and antioxidant benefits.

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Attenuating UVA-induced oxidative stress of human skin fibroblasts by enhancing bioactive components of Armillaria luteo-virens by Lactobacillus delbrueckii subsp. Bulgaricus fermentation

Cited by 2 publications

References 49 publications

Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells

Protective effects of Aureobasidium pullulans lysate on UV-damaged human skin fibroblasts and HaCaT cells

Comparison and Assessment of Anti‐Inflammatory and Antioxidant Capacity Between EGCG and Phosphatidylcholine‐Encapsulated EGCG

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