Attenuation by Metallothionein of Early Cardiac Cell Death via Suppression of Mitochondrial Oxidative Stress Results in a Prevention of Diabetic Cardiomyopathy

Abstract

These results suggest that attenuation of early-phase cardiac cell death by MT results in a significant prevention of the development of diabetic cardiomyopathy. This process is mediated by MT suppression of mitochondrial oxidative stress.

Ginsenoside Rg1 ameliorates oxidative stress and myocardial apoptosis in streptozotocin-induced diabetic rats

“…Diabetes was found to be associated with enhanced apoptosis and necrosis in both ischemic and nonischemic human myocardia, an adverse effect that is mediated, at least in part, by CASP3 (Chowdhry et al, 2007). Cardiac apoptosis as a major early cellular response in DM is induced by hyperglycemia-derived oxidative stress that activates a mitochondrial cytochrome c-mediated CASP3 pathway (Cai et al, 2006). Cleaved CASP3 has also been found to be elevated in vivo in STZ-and obesity-induced DM mice (Li et al, 2008;Chen et al, 2009).…”

Ameliorative effect ofAegle marmelosleaf extract on early stage alloxan-induced diabetic cardiomyopathy in rats

“…These free radical species result in oxidative damage to the heart, kidneys, eyes, nerves, liver, small and large vessels and gastrointestinal system (Mishra et al, 2010). Inflammatory changes, hypertrophic remodeling and cell death have been reported to occur in the diabetic hearts in experimental animals as early as 7 days after the induction of the diabetic state (Cai et al, 2006). Administration of AME was found to decrease the FBG and total cholesterol significantly as compared to the untreated diabetic animals.…”

“…DCM is characterized by diastolic dysfunction, accumulation of extracellular matrix, activation of the inflammatory mechanisms, apoptosis and alterations in calcium homeostasis in the cardiomyocytes (Cai et al, 2006). The exact pathogenesis of DCM is complex and multifactorial.…”

Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice

“…Strategies that either reduce reactive oxygen species or augment myocardial antioxidant defense mechanisms have been shown to be efficacious in reducing diabetes-induced myocardial dysfunction (51)(52)(53)(54). To study the effect of rapamycin in T2D-induced oxidative stress, we determined the levels of glutathione, a marker of oxidative stress.…”