Attenuation effects of prenatal stress by early postnatal stimulation in different research models

Liaudat, Ana Cecilia; Mayer, Nóra; Vivas, Adriana; Romanini, María Cristina; Bosch, Pablo; Rodríguez, Nancy

doi:10.15406/mojap.2018.05.00211

Cited by 1 publication

(1 citation statement)

References 84 publications

(88 reference statements)

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“…Studies have shown that increased levels of Rab GDIα expression in the HC, when mice are injected with MK 801. Mineralocorticoid receptor and glucocorticoid receptor mRNA levels are downregulated in PRS mice [ 56 ].…”

Section: Animal Models Of Schizophreniamentioning

confidence: 99%

Understanding translational research in schizophrenia: A novel insight into animal models

et al. 2023

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Schizophrenia affects millions of people worldwide and is a major challenge for the scientific community. Like most psychotic diseases, it is also considered a complicated mental disorder caused by an imbalance in neurotransmitters. Due to the complexity of neuropathology, it is always a complicated disorder. The lack of proper understanding of the pathophysiology makes the disorder unmanageable in clinical settings. However, due to recent advances in animal models, we hope we can have better therapeutic approaches with more success in clinical settings. Dopamine, glutamate, GABA, and serotonin are the neurotransmitters involved in the pathophysiology of schizophrenia. Various animal models have been put forward based on these neurotransmitters, including pharmacological, neurodevelopmental, and genetic models. Polymorphism of genes such as dysbindin, DICS1, and NRG1 has also been reported in schizophrenia. Hypothesis based on dopamine, glutamate, and serotonin are considered successful models of schizophrenia on which drug therapies have been designed to date. New targets like the orexin system, muscarinic and nicotinic receptors, and cannabinoid receptors have been approached to alleviate the negative and cognitive symptoms. The non-pharmacological models like the post-weaning social isolation model (maternal deprivation), the isolation rearing model etc. have been also developed to mimic the symptoms of schizophrenia and to create and test new approaches of drug therapy which is a breakthrough at present in psychiatric disorders. Different behavioral tests have been evaluated in these specific models. This review will highlight the currently available animal models and behavioral tests in psychic disorders concerning schizophrenia.

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Section: Animal Models Of Schizophreniamentioning

confidence: 99%