Attenuation of cardiovascular response to direct laryngoscopy and intubation, comparative study of lignocaine, nifedipine, and placebo during general anesthesia

Manne, Venkata Sesha Sai Krishna; Paluvadi, Venkata Raghavendra

doi:10.4103/0259-1162.200227

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…This laryngoscopic response in corresponding patients is prone to incidents like pulmonary oedema, myocardial deficits, and cerebrovascular mishaps. At least in such individuals, it is essential to attenuate these detrimental hypertensive and rate-responses 4 . Lignocaine is the chief example of an amino-amide local anaesthetic used as a general anaesthetic adjuvant.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on the Effects of Lignocaine Nebulization with I/V Lignocaine on Stress Response to Laryngoscopy and Tracheal Intubation

Baloch,

Kalim,

Hassan

et al. 2023

PJMHS

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Aim: To determine the frequency of any immediate side effects associated with the use of lignocaine in patients. Methodology: Randomized control trial. Sindh Institute of Urology and Transplantation, Karachi from 1st December 2021 to 31st May 2022. Ninety patients enrolled for laryngoscopy and endotracheal intubation. Patients were randomly allocated into three groups on the basis of the treatment. Thirty patients in group I was treated with 2% lignocaine 1.5mg/kg was given by intravenous route, 30 in group N was received 4% lignocaine 1.5mg/kg was given by nebulization and 30 in groups C treated as control group in whom normal saline placebo. The hemodynamic response and side effect was recorded in all patients. Results: The mean heart rate was not statistically significant among groups at baseline and 1 min, 3min to 8 min, while it was statistically significant at 2 min and 9 min among the groups. Mean atrial BP was statistically significant among groups during 2 min to 6 min and then 8 min. regarding immediate side effects, the frequency of side effects were lower in group N and group I than in group C. However, the rate of drowsiness, tremors, and hypoxia was significantly higher in group C compare to group N and group I. Conclusion: Lignocaine is a safe drug and proved to be safe and effective method for the improvement of hemodynamic response to intubation and laryngoscopy. Keywords: Lignocaine, Nebulization of 4%lignocaine, Hemodynamic response, Endotracheal intubation

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Section: Introductionmentioning

confidence: 99%

Comparative Study on the Effects of Lignocaine Nebulization with I/V Lignocaine on Stress Response to Laryngoscopy and Tracheal Intubation

Baloch,

Kalim,

Hassan

et al. 2023

PJMHS

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“…The discharge of vasoactive mediators practically accompanies direct manipulation of these structures after initiation of anaesthesia. 2 Cardiovascular reaction to laryngeal manipulation causes a rise in pulse rate, blood pressure, central nervous system pressures, intraocular tension and cardiac dysrhythmias. 3 Moreover, it can also lead to cardiac arrest.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Efficacy of Intravenous Lignocaine and Intravenous Dexmedetomidine in Attenuation of Hemodynamic Stress Response to Laryngoscopy and Endotracheal Intubation

Nand

Feroz²,

Ahmed³

et al. 2022

PAFMJ

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Objective: To study the effect of intravenous Lignocaine and Dexmedetomidine to attenuate cardiovascular stress reaction to laryngeal manipulation. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Anesthesia, Combined Military Hospital, Peshawar Pakistan, from Oct 2019 to Apr 2020. Methodology: Patients were randomly divided into two Groups by lottery method. Seventy-three were in the intravenous Lignocaine-Group-(A), while 73 patients were in the intravenous Dexmedetomidine-Group-(B). Blood pressure, Pulse rate and ECG were documented at the start of general anaesthesia and after 1, 3 and 5 minutes of intubation. Efficacy was defined if systolic pressure and pulse remained within 20% of the patient's native findings between 1 and 5 minutes after endotracheal intubation. Results: A total of 146 patients were included in the stud. The mean baseline systolic BP of Group-A was 121.34±4.47mmHg and mean baseline diastolic BP was 80.31±3.57mmHg. While mean Baseline Systolic BP WAS 121.19±4.37mmHg in Group-B and mean baseline diastolic BP was 80.04±3.66mmHg. Efficacy was seen 74% patients of Group-A and 90.4% of Group-B (p=0.009). Conclusion: Dexmedetomidine 1 microgram/kg blunts the cardiovascular sympathetic reaction to laryngeal manipulation more pronounced than Lignocaine 1.5 milligram/kg without any harmful outcomes.

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Perioperative Haemodynamics

McAndrew¹,

Cecconi²,

Rhodes³

2019

Hemodynamic Monitoring

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Attenuation of cardiovascular response to direct laryngoscopy and intubation, comparative study of lignocaine, nifedipine, and placebo during general anesthesia

Cited by 5 publications

References 20 publications

Comparative Study on the Effects of Lignocaine Nebulization with I/V Lignocaine on Stress Response to Laryngoscopy and Tracheal Intubation

Comparative Study on the Effects of Lignocaine Nebulization with I/V Lignocaine on Stress Response to Laryngoscopy and Tracheal Intubation

Comparison of the Efficacy of Intravenous Lignocaine and Intravenous Dexmedetomidine in Attenuation of Hemodynamic Stress Response to Laryngoscopy and Endotracheal Intubation

Perioperative Haemodynamics

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