Attenuation of Cue-Induced Heroin-Seeking Behavior by Cannabinoid CB1 Antagonist Infusions into the Nucleus Accumbens Core and Prefrontal Cortex, but Not Basolateral Amygdala

Alvarez-Jaimes, Lily; Polis, Ilham; Parsons, Loren H.

doi:10.1038/sj.npp.1301630

Cited by 54 publications

(46 citation statements)

References 80 publications

(86 reference statements)

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“…And interestingly, the response-reinstating effect of menthol was observed only in rats that had been trained to self-administer nicotine with pre-session menthol but not in the rats that had received exactly the same nicotine self-administration training but without pre-session menthol. This finding can be explained in the frame of the above discussed occasion-setting effect of menthol and is consistent with previous studies, in which discriminative stimuli effectively reinstated extinguished drug-seeking behavior in animals that were trained to self-administer cocaine, heroin, alcohol, nicotine, and sucrose (Alvarez-Jaimes et al, 2008; Barker et al, 2014; Burbassi and Cervo, 2008; Ciccocioppo et al, 2001; Gracy et al, 2000; Kallupi et al, 2013; Katner et al, 1999; Widholm et al, 2011; Wing and Shoaib, 2008). The present results mirror our previous report that showed that caffeine influences nicotine seeking (Liu and Jernigan, 2012).…”

Section: Discussionsupporting

confidence: 92%

Effects of menthol and its interaction with nicotine-conditioned cue on nicotine-seeking behavior in rats

et al. 2017

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Rationale Increasing clinical evidence suggests that menthol, a significant flavoring additive in tobacco products, may contribute to smoking and nicotine dependence. Relapse to smoking behavior presents a formidable challenge for the treatment of tobacco addiction. An unresolved issue is whether the mentholation of tobacco products precipitates relapse to tobacco use in abstinent smokers. Objectives The present study examined the effects of menthol on the perseverance and relapse of nicotine-seeking behavior in rats. Methods Male Sprague-Dawley rats were trained to press a lever for intravenous nicotine self-administration (0.03 mg/kg/infusion) under a fixed-ratio 5 schedule of reinforcement. Each nicotine infusion was signaled by the presentation of a sensory stimulus that was established as a discrete nicotine-conditioned cue. Five minutes prior to the sessions, the rats received an intraperitoneal injection of menthol (0.1 mg/kg) or vehicle. In the subsequent extinction test sessions, nicotine was unavailable with or without menthol and/or the nicotine-conditioned cue. The reinstatement tests were performed the following day after the extinction criterion was met. Menthol was also tested on food-seeking responses. In a subset of nicotine-trained rats, a TRPM8 antagonist RQ-00203078 was given prior to menthol administration. Results Continued administration of menthol sustained responses on the previously active and nicotine-reinforced lever in the extinction tests. The re-administration of menthol after extinction reinstated active lever responses. In both the extinction and reinstatement tests, a combination of pre-session menthol administration and cue re-presentation during the session produced a more robust behavioral effect than either menthol or the cue alone. No such effects of menthol was observed in food trained rats. RQ-00203078 did not change menthol effect on nicotine seeking. Conclusion These data demonstrated that menthol specifically sustained and reinstated nicotine-seeking behavior and this effect was independent of TRPM8 activity. These findings suggest that menthol in most tobacco products, even not menthol-labeled, may contribute to the perseverance of and relapse to tobacco-seeking behavior.

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Section: Discussionsupporting

confidence: 92%

Effects of menthol and its interaction with nicotine-conditioned cue on nicotine-seeking behavior in rats

et al. 2017

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“…That is, CB1 agonists administered systemically induce reinstatement of cocaine and heroin seeking, whereas CB1 antagonists block reinstatement of drug seeking (De Vries et al 2001. For heroin seeking, these effects have been localized to the core and IL-mPFC (Alvarez-Jaimes et al 2008). Hence, these effects of CB1 agents on drug seeking are in apparent opposition to their effects on fear extinction.…”

Section: Testing the Modelmentioning

confidence: 86%

Extinction circuits for fear and addiction overlap in prefrontal cortex

Peters

Kalivas²,

Quirk³

2009

Learn. Mem.

666

642

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Extinction is a form of inhibitory learning that suppresses a previously conditioned response. Both fear and drug seeking are conditioned responses that can lead to maladaptive behavior when expressed inappropriately, manifesting as anxiety disorders and addiction, respectively. Recent evidence indicates that the medial prefrontal cortex (mPFC) is critical for the extinction of both fear and drug-seeking behaviors. Moreover, a dorsal-ventral distinction is apparent within the mPFC, such that the prelimbic (PL-mPFC) cortex drives the expression of fear and drug seeking, whereas the infralimbic (IL-mPFC) cortex suppresses these behaviors after extinction. For conditioned fear, the dorsal-ventral dichotomy is accomplished via divergent projections to different subregions of the amygdala, whereas for drug seeking, it is accomplished via divergent projections to the subregions of the nucleus accumbens. Given that the mPFC represents a common node in the extinction circuit for these behaviors, treatments that target this region may help alleviate symptoms of both anxiety and addictive disorders by enhancing extinction memory.

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“…IL neurons are Fos-activated in context-induced heroin reinstatement and inactivation of IL decreases heroin reinstatement (Bossert et al, 2011; Bossert et al, 2012). Increased zif268 is observed in IL after cue-induced reinstatement of heroin seeking (Koya et al, 2006), and inactivation of IL decreased cue and heroin prime reinstatement of heroin seeking (Rogers et al, 2008), as did infusion of CB1 antagonists in IL (Alvarez-Jaimes et al, 2008). IL inactivation also decreases cue-induced but not methamphetamine prime-induced reinstatement (Rocha and Kalivas, 2010).…”

Section: Evidence For An Imperfect Mapping Between Pl/il and Go/stopmentioning

confidence: 99%

Differential roles of medial prefrontal subregions in the regulation of drug seeking

et al. 2015

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The prefrontal cortex plays an important role in shaping cognition and behavior. Many studies have shown that medial prefrontal cortex (mPFC) plays a key role in seeking, extinction, and reinstatement of cocaine seeking in rodent models of relapse. Subregions of mPFC appear to play distinct roles in these behaviors, such that the prelimbic cortex (PL) is proposed to drive cocaine seeking and the infralimbic cortex (IL) is proposed to suppress cocaine seeking after extinction. This dichotomy of mPFC function may be a general attribute, as similar dorsal-ventral distinctions exist for expression vs. extinction of fear conditioning. However, other results indicate that the role of mPFC neurons in reward processing is more complex than a simple PL-seek vs. IL-extinguish dichotomy. Both PL and IL have been shown to drive and inhibit drug seeking (and other types of behaviors) depending on a range of factors including the behavioral context, the drug-history of the animal, and the type of drug investigated. This heterogeneity of findings may reflect multiple subcircuits within each of these PFC areas supporting unique functions. It may also reflect the fact that the mPFC plays a multifaceted role in shaping cognition and behavior, including those overlapping with cocaine seeking and extinction. Here we discuss research leading to the hypothesis that dorsal and ventral mPFC differentially control drug seeking and extinction. We also present recent results calling the absolute nature of a PL vs. IL dichotomy into question. Finally, we consider alternate functions for mPFC that correspond less to response execution and inhibition and instead incorporate the complex cognitive behavior for which the mPFC is broadly appreciated.

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Attenuation of Cue-Induced Heroin-Seeking Behavior by Cannabinoid CB1 Antagonist Infusions into the Nucleus Accumbens Core and Prefrontal Cortex, but Not Basolateral Amygdala

Cited by 54 publications

References 80 publications

Effects of menthol and its interaction with nicotine-conditioned cue on nicotine-seeking behavior in rats

Effects of menthol and its interaction with nicotine-conditioned cue on nicotine-seeking behavior in rats

Extinction circuits for fear and addiction overlap in prefrontal cortex

Differential roles of medial prefrontal subregions in the regulation of drug seeking

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