Attenuation of morphine tolerance by minocycline and pentoxifylline in naive and neuropathic mice

Mika, Joanna; Wawrzczak-Bargieła, Agnieszka; Osikowicz, Maria; Makuch, Wioletta; Przewłocka, Barbara

doi:10.1016/j.bbi.2008.07.005

Cited by 148 publications

(128 citation statements)

References 78 publications

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“…In accordance to our results, an increased immunoreactivity and CB2R mRNA expression in the spinal cord and the nerve sections proximal to the spinal nerve ligation site also have been demonstrated by other studies (Zhang et al, 2003;Wotherspoon et al, 2005). In summary and taking account that DOPr is mainly located in neurons and CB2R in glial cells, the nerve injury-induced degeneration of C fibers (Ossipov et al, 2000) and glial activation (Mika et al, 2009) could be the principals responsible for the decreased and increased synthesis of peripheral DOPr and CB2R that leads to the lower peripheral potency of DPDPE compared with JWH-015 during neuropathic pain.…”

supporting

confidence: 93%

The Role of Nitric Oxide in the Local Antiallodynic and Antihyperalgesic Effects and Expression of δ-Opioid and Cannabinoid-2 Receptors during Neuropathic Pain in Mice

Hervera¹,

Negrete²,

Leánez³

et al. 2010

J Pharmacol Exp Ther

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Both ␦-opioid receptor (DOPr) and cannabinoid-2 receptor (CB2R) agonists attenuate neuropathic pain, but the precise mechanism implicated in these effects is not completely elucidated. We investigated whether nitric oxide synthesized by neuronal (NOS1) or inducible (NOS2) nitric-oxide synthases could modulate DOPr and/or CB2R antiallodynic and antihyperalgesic effects through the peripheral nitric oxide-cGMP-protein kinase G (PKG) pathway activation and affect their expression during neuropathic pain. , and NOS2-KO mice, also was assessed. The subplantar administration of NANT, L-NIL, ODQ, or Rp-8-pCPTcGMPs dose-dependently inhibited neuropathic pain and enhanced the local effects of DPDPE or JWH-015. Moreover, although the basal levels of DOPr and CB2R mRNA were similar between WT and NOS-KO animals, nerve injury only decreased (DOPr) or increased (CB2R) their expression in the dorsal root ganglia of WT and NOS2-KO mice, and not in NOS1-KO mice. Results suggest that inactivation of the nitric oxide-cGMP-PKG peripheral pathway triggered by NOS1 and NOS2 enhanced the peripheral actions of DOPr and CB2R agonists and that nitric oxide synthesized by NOS1 is implicated in the peripheral regulation of DOPr and CB2R gene transcription during neuropathic pain.

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supporting

confidence: 93%

The Role of Nitric Oxide in the Local Antiallodynic and Antihyperalgesic Effects and Expression of δ-Opioid and Cannabinoid-2 Receptors during Neuropathic Pain in Mice

Hervera¹,

Negrete²,

Leánez³

et al. 2010

J Pharmacol Exp Ther

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“…This effect is possibly due to the reduction of the formation of endoperoxides as a consequence of the elevated cAMP levels that inhibit the cyclooxygenase within the arachidonic pathway (29). Furthermore, it is been shown that pentoxifylline both enhances morphine's analgesic effects by targeting microglial activation during morphine therapy/ treatment in mice (30) and also decreases pro-infl ammatory cytokines contributing to nociceptive in rats (31).…”

Section: Discussionmentioning

confidence: 99%

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Moradi¹,

Mahmoodi²,

Raoofi³

et al. 2015

BLL

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Abstract:Background: Knowledge about harmful effects of morphine on hormone secretion seems to be necessary. The aim of the present study was to evaluate the effect of pentoxifylline on side effects derived by morphine on hypophyso-gonadal hormones of male rats. Methods: 32 male rats were divided into the 4 groups of OSS: control (received 40 g Sucrose/l drinking water and intraperitoneal injection of 1 l/kg normal saline), OMS: morphine group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and intraperitoneal injection of 1 l/kg normal saline), NMS: morphine+naltrexane group (received 0.4 mg/l + 40 g Sucrose/l in drinking water and IP injection dose of 10 mg/kg/ml/day Naltrexane) and PMS: morphine + pentoxifylline group (received 0.4 mg/dl + 40 g Sucrose/l in drinking water and IP injection dose of 12 mg/kg/ml/day Pentoxifylline) for 56 days, respectively. Results: Serum levels of testosterone, LH, FSH hormones were measured. Pentoxifylline increased serum levels of testosterone, LH, FSH hormones compared to control, morphine and morphine-naltrexane groups. Conclusion: Pentoxifylline has a signifi cant effi cacy for increasing serum levels of sexual hormones. Considering that Pentoxifylline is safe and cheap, with easy application, we suggest for the usage of this drug for improving semen parameter's quality before performing ART for the treatment of morphine addicts (Fig. 1, Ref. 31). Text in PDF www.elis.sk.

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“…Neither acute nor chronic minocycline administration altered basal mechanical thresholds of either sham or OB rats. Similarly, studies have demonstrated that acute (Mika et al, 2009), repeated (3 days) (Yoon et al, 2012), or chronic (Guasti et al, 2009) minocycline administration does not alter nociceptive responding to mechanical stimuli in the absence of a noxious insult/nerve injury. Thus, microglial activation may not underlie the OB-related increase in nociceptive responding to sensory stimuli (prior to SNL), indicating a dissociation between depressive-like behaviour and allodynia in the absence of nerve injury.…”

Section: Acute Minocycline Pretreatment Prevents the Development Of Nmentioning

confidence: 95%

Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression

Burke¹,

Kerr²,

Moriarty³

et al. 2014

Brain, Behavior, and Immunity

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116

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Attenuation of morphine tolerance by minocycline and pentoxifylline in naive and neuropathic mice

Cited by 148 publications

References 78 publications

The Role of Nitric Oxide in the Local Antiallodynic and Antihyperalgesic Effects and Expression of δ-Opioid and Cannabinoid-2 Receptors during Neuropathic Pain in Mice

The Role of Nitric Oxide in the Local Antiallodynic and Antihyperalgesic Effects and Expression of δ-Opioid and Cannabinoid-2 Receptors during Neuropathic Pain in Mice

Chorionic morphine, naltrexone and pentoxifylline effect on hypophyso-gonadal hormones of male rats

Minocycline modulates neuropathic pain behaviour and cortical M1–M2 microglial gene expression in a rat model of depression

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