Attenuation of negative effects of senescence in human skin using an extract from Sphingomonas hydrophobicum: development of new skin care solution

Abstract

Objective Intrinsic skin ageing is mainly caused by cellular senescence. p16 and p21 are two important tumour suppressor proteins that play essential roles during cell proliferation and ageing through regulating the expression of several genes. Moreover, physical changes between the ages of 55 and 60 years affect one's physical and disrupt self‐esteem. The cosmetics industry has focused on bioactive substances derived from natural products such as plants, mushrooms and marine algae to counteract the deleterious effect on skin senescence. Besides these products, compounds produced by bacteria may decelerate individual senescence. Methods In order to evaluate the potential benefits of bacteria extract over skin ageing, we investigated whether a Sphingomonas hydrophobicum (SH) extract is able to protect our skin against senescence mechanisms. We used an ageing full‐thickness skin equivalent model, which was treated or not with the bacteria extract in a systemic way for 42 days. p21 and p16 and senescence‐associated galactosidase activity were used to detect cellular senescence with immunohistology. Using a psychobiological approach, we evaluated in vivo the effect of SH extract on self‐esteem, isotropy and suppleness. Results Sphingomonas extract significantly suppressed senescence associated with β‐galactosidase activation. It also significantly inhibited the expression of cell cycle inhibitors (p21 and p16). At the same time, the bacteria extract has a significant positive impact on the issue by increasing the expression of versican and fibrillin‐1. Significant improvements of self‐esteem were reported after 56 days of SH extract application. These psychological benefits were accompanied by a significant improvement in skin suppleness and isotropy. Conclusion Sphingomonas extract delays intrinsic skin ageing process by inhibiting cellular senescence, and has also the capability to restructure the skin. These beneficial physiological effects induced by SH extract have a positive influence on self‐esteem. Because skin ageing causes emotional distress, SH extract can serve as an anti‐ageing cosmeceutical agent and help to build a better psychological health, and help individuals to assume ageing.

Increase in subjective well‐being and psychological health after application of C8‐silk lipoamino acid functionalized pigments included in a foundation

“…For example, an increase in positive and a decrease in negative emotions after hairdressing by professional hairdressers were found [27]. In a recent study, Gervason [7] noted a relationship between cosmetic application, mood and selfesteem in a population of women aged 60 and over. Scientific approach such as the neuroscience approach or the psychophysiological approach, as we used in this study, is now available to study this link between emotions and cosmetic, and to prove cosmetic efficacy on this topic [28].…”

“…Recently, Gervason et al . noted that daily application of a cosmetic cream during 56 days is followed by an increase in self‐esteem and mood in 60‐year‐old women.…”

“…The perception of their own image is profoundly altered, not to mention their seductive abilities hindered. Recently, Gervason et al [7] noted that daily application of a cosmetic cream during 56 days is followed by an increase in self-esteem and mood in 60-year-old women.…”

Sustainable Sources from Aquatic Organisms for Cosmeceuticals Ingredients

“…Aging of skin is a complex process involving oxidative, epigenetic, and genotoxic stresses; telomere shortening; and mitochondrial dysfunction; causing skin cell senescence [18]. It has been proposed that skin aging is related to the alteration of the extracellular matrix (ECM) in both the dermis and epidermis.…”

Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: An Emerging Frontier

“…It was observed that metabolites secreted by a probiotic Lactobacillus fermentum, isolated from human fecal matter, can attenuate multiple characteristic markers of senescence in preadipocytes such as cellular hypertrophy, SA-β-gal activity, induction of SASP, DNA damage response, Akt/mTOR pathway and activation of cell cycle inhibitor signaling (Kumar et al, 2020). Using a reconstructed skin model, another study reported that extract of bacterium Sphingomonas hydrophobicum can delay skin senescence by attenuating the activation of p21, p16 Ink4a cell cycle inhibitors and SA-β-gal activity resulting in restructuring of skin as well as psychobiological effects (Gervason et al, 2019). It is thus conceivable that secretory factors of the gut microbiota can influence cellular senescence, although further in vivo studies are warranted.…”