Attenuation of Postoperative Acute Liver Failure by Mesenchymal Stem Cell Treatment Due to Metabolic Implications

Abstract

MSCs ameliorated hepatic dysfunction and improved liver regeneration after extended resection by paracrine mechanisms. They may represent a new therapeutic option to treat posthepatectomy acute liver failure.

Mesenchymal Stem Cells Transplantation following Partial Hepatectomy: A New Concept to Promote Liver Regeneration—Systematic Review of the Literature Focused on Experimental Studies in Rodent Models

“…For the aims of this systematic review 7 studies ( n = 7) were included and reviewed in regard to MSCs transplantation following PH [14, 16–21]. From these studies, in five, authors performed ADSCs transplantation [14, 17–19, 21], whereas, in two, authors transplanted BM-MSCs [16, 20] (Table 1).…”

“…From these studies, in five, authors performed ADSCs transplantation [14, 17–19, 21], whereas, in two, authors transplanted BM-MSCs [16, 20] (Table 1). In all included papers on MSCs transplantation following PH, authors used rats as experiment animals, except from the study of Saito et al [19], in which authors have performed their experiments in mice.…”

“…In five studies authors performed ADSCs transplantation following PH [14, 17–19, 21]. Among included literature on MSCs transplantation, specifically reviewed for the aims of this systematic review, effects of MSCs transplantation in the enhancement of LG after PH and improvement of the hepatic function are evaluated and compared.…”

“…In a recent study of good quality published by Tautenhahn et al [14], authors performed a 90% PH in DPPIV-deficient F344-Fischer rats and transplanted ADSCs by splenic application. It is noteworthy that authors of this article performed the most extensive PH described in included published literature.…”

“…Furthermore, MSCs improved LG by presenting proproliferative and antiapoptotic properties, thus hampering disease progress [11–13]. These proregenerative properties of MSCs might also enhance the regenerative capacity of the remaining liver after extensive resection [14]. …”