Attenuation of renal ischemia/reperfusion injury by açaí extract preconditioning in a rat model

Morsy, Engy M. El; Ahmed, Maha A.E.; Ahmed, Ashraf M.

doi:10.1016/j.lfs.2014.11.013

Cited by 32 publications

(27 citation statements)

References 63 publications

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“…Inflammation has been recognized as a key mechanism underlying the pathogenesis of renal I/R injury (21). In response to I/R, neutrophils, lymphocytes and macrophages infiltrate the damaged tissue, which can lead to microcirculatory failure as a result of the reduction in renal blood flow (22,23).…”

Section: Discussionmentioning

confidence: 99%

Gypenoside attenuates renal ischemia/reperfusion injury in mice by inhibition of ERK signaling

Zhu

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Gynostemma pentaphyllum is a traditional Chinese medicine reported to possess a wide range of health benefits. As the major component of G. pentaphyllum, gypenoside (GP) displays various anti-inflammatory and anti-oxidant properties. However, it is unclear whether GP can protect against ischemia/reperfusion (I/R)-induced renal injury, and the underlying molecular mechanisms associated with this process remain unknown. In the present study, a renal

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Section: Discussionmentioning

confidence: 99%

Gypenoside attenuates renal ischemia/reperfusion injury in mice by inhibition of ERK signaling

Zhu

et al. 2016

Experimental and Therapeutic Medicine

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“…However, taking kidney transplantation as an example, ischemia/reperfusion may cause delayed recovery of transplant renal function, and in cases of inducing acute rejection may result in acute heart failure of the transplanted kidney at an early stage (5). With the application of anti-rejection drugs in clinical contexts, the occurrence rate of acute rejection has decreased to 80% (19). The year survival rate of transplant kidney has increased from 45 to 90% (19).…”

Section: Discussionmentioning

confidence: 99%

“…With the application of anti-rejection drugs in clinical contexts, the occurrence rate of acute rejection has decreased to 80% (19). The year survival rate of transplant kidney has increased from 45 to 90% (19). Chronic organ damage induced by RIRI has attracted increasing attention (20).…”

Section: Discussionmentioning

confidence: 99%

“…Cell apoptosis is an active process of death under physiological and pathological conditions, and is regulated by internal and external factors (19). During I/RIRI process, necrosis of neurons and apoptosis are both observed (27).…”

Section: Discussionmentioning

confidence: 99%

“…Caspase-3 is the most critical apoptotic protease in caspases cascade reaction (30). Caspase-3 plays a role in apoptosis process started by various procedures (19). It can be activated by splitting of DNA cyclin-dependent kinases to change its structure and promote cell apoptosis (29).…”

Section: Discussionmentioning

confidence: 99%

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Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury

Ding

Huang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Tanshinone IIA is a chemical compound extracted from the root of traditional Chinese herb Salvia miltiorrhiza Bunge. Tanshinone IIA has been suggested to possess anti-inflammatory activity and antioxidizing capability. Recently, accumulating results have indicated the antitumor activity of tanshinone IIA; thus, it has attracted increasing attention. In addition, tanshinone IIA has been indicated to attenuate ischemia/reperfusion induced renal injury (I/RIRI); however, little is known regarding the underlying mechanisms involved in this process. In the present study an I/RIRI rat model was used to analyze the effects of tanshinone IIA on myeloperoxidase (MPO), TNF-α and IL-6 activities using ELISA kits. Furthermore, macrophage migration inhibitory factor (MIF), cleaved caspase-3, B-cell lymphoma 2 (Bcl-2) and p38 mitogen-activated protein kinase (MAPK) protein expression levels were evaluated using western blot analysis. The results indicated that tanshinone IIA protected renal function in I/RIRI rats. ELISA demonstrated that tanshinone IIA significantly reduced MIF, TNF-α and IL-6 activities in I/RIRI rats. Western blot analysis showed that tanshinone IIA significantly suppressed MIF, cleaved caspase-3 and p38 MAPK protein expression levels in I/RIRI rats. The present results suggest that tanshinone IIA pretreatment attenuates I/RIRI via the downregulation of MPO expression, inflammation, MIF, cleaved caspase-3 and p38 MAPK.

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Inhibition of boldenone‐induced aggression in rats by curcumin: Targeting TLR4/MyD88/TRAF‐6/NF‐κB pathway

El-Shamarka¹,

Eliwa

Ahmed

2021

J Biochem & Molecular Tox

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The illicit abuse of anabolic steroids is associated with brutal aggression, which represents a serious health hazard and social threat. Boldenone is commonly used for doping by athletes and adolescents for esthetic purposes and to enhance performance and endurance during competitions. However, the mechanistic pathways underlying boldenone-induced behavioral deviations and neuronal toxicity have not yet been elucidated. On the other hand, the natural polyphenol curcumin is appreciated for its relative safety, potent antioxidant activity, and anti-inflammatory properties. Therefore, the present study was initiated to explore the signaling pathways underlying boldenone-induced anxiety and aggression in rats, and the protective effects of curcumin. To achieve this aim, male Wistar albino rats were randomly distributed into control, curcumin (100 mg/kg in sesame oil, p.o., once daily), boldenone (5 mg/kg, intramuscular, once weekly), and combination groups.Rats were challenged across the open field, irritability, defensive aggression, and resident-intruder tests. The prefrontal cortex was used to assess serotonin level,

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Attenuation of renal ischemia/reperfusion injury by açaí extract preconditioning in a rat model

Cited by 32 publications

References 63 publications

Gypenoside attenuates renal ischemia/reperfusion injury in mice by inhibition of ERK signaling

Gypenoside attenuates renal ischemia/reperfusion injury in mice by inhibition of ERK signaling

Tanshinone IIA pretreatment attenuates ischemia/reperfusion-induced renal injury

Inhibition of boldenone‐induced aggression in rats by curcumin: Targeting TLR4/MyD88/TRAF‐6/NF‐κB pathway

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