2004
DOI: 10.1111/j.1574-6968.2004.tb09555.x
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Attenuation regulation of amino acid biosynthetic operons in proteobacteria: comparative genomics analysis

Abstract: Candidate attenuators were identified that regulate operons responsible for biosynthesis of branched amino acids, histidine, threonine, tryptophan, and phenylalanine in gamma- and alpha-proteobacteria, and in some cases in low-GC Gram-positive bacteria, Thermotogales and Bacteroidetes/Chlorobi. This allowed us not only to describe the evolutionary dynamics of regulation by attenuation of transcription, but also to annotate a number of hypothetical genes. In particular, orthologs of ygeA of Escherichia coli wer… Show more

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Cited by 67 publications
(30 citation statements)
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“…The antiterminator and terminator hairpins in all genomes contain complementary triples gGCC-rGCy-GGCC where absolutely conserved positions are set in capitals. This is analogous to the situation in proteobacteria, where the patterns involved in multiple interactions within attenuators are conserved at large evolutionary distances [8]. In C. diphteriae , candidate attenuators were found upstream of both biosynthetic operons trpB 1 EDGC and trpB 2 A .…”
Section: Resultsmentioning
confidence: 57%
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“…The antiterminator and terminator hairpins in all genomes contain complementary triples gGCC-rGCy-GGCC where absolutely conserved positions are set in capitals. This is analogous to the situation in proteobacteria, where the patterns involved in multiple interactions within attenuators are conserved at large evolutionary distances [8]. In C. diphteriae , candidate attenuators were found upstream of both biosynthetic operons trpB 1 EDGC and trpB 2 A .…”
Section: Resultsmentioning
confidence: 57%
“…Following an approach described previously [8], we systematically analysed the upstream regions of amino acid biosynthesis and aminoacyl-tRNA synthetase operons. Candidate regulatory structures were found upstream of genes involved in tryptophan, cysteine, and leucine metabolism.…”
Section: Resultsmentioning
confidence: 99%
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“…32,33 In S. aureus, a Ile-T-box was found in the up-stream region of ileS, which encodes Ile-tRNA synthetase 33,34 ; and a weak T-box motif located in the upstream region of ilvDBHC-leuABCD-ilvA operon. 35 Thus, we cannot exclude Ile-tRNA dependent regulation of ilv-leu operon in S. aureus.…”
mentioning
confidence: 99%