SummaryOne of the most challenging subsystems for the CubeSats is the attitude determination and control system (ADCS) because it involves hardware and software integration, advanced strategies and algorithms to determine and control the attitude that impacts on space maneuvering and well working of a large set of payload (e.g., the optical payload). Although ADCS is largely studied, it still requires further investigations and analysis in order to achieve high‐performance and a reduced efforts. This paper presents an effective and reliable solution for the ADCS of CubeSats involved in Earth observation missions. The solution is based on an innovative framework that leverages the strengths of two distinct methodologies—H‐infinity optimal output feedback control and the extended Kalman filter (EKF)‐to significantly enhance the pointing stability of satellite systems. While H‐infinity optimal output feedback control is traditionally associated with partial state knowledge, we intentionally extend its application to scenarios with complete state information. The study includes a comparative performance analysis involving three algorithm configurations: the classic combination of EKF and model predictive control (MPC), the utilization of H‐infinity optimal output feedback control without EKF, and our proposed integrated approach. Performance evaluations are based on extrinsic indicators, demonstrating the advantages of our method in terms of pointing stability and overall control system performance. This research underscore the significance of combining innovative thinking with well‐established methodologies, unlocking new possibilities for stability enhancement in a range of engineering applications.