This article deals with the problem of attitude tracking control for flexible satellite under flexible vibration disturbance, actuator fault and time delay. Based on disturbance observer and fault tolerant control techniques, the flexible vibration disturbance and actuator fault are effectively estimated by disturbance observer and fault estimation observer, respectively. Meanwhile, a delay-dependent attitude tracking feedback controller is designed to ensure that the reference attitude is stably tracked. To reduce the conservatism of the designed algorithm, a time delay correlative decomposition factor is introduced to make the flexible satellite have a better performance for attitude tracking control. Finally, the effectiveness of the proposed method is illustrated by numerical simulations.