Attitudes and behavior of peripheral arterial disease patients toward influencing their physician’s prescription of cholesterol-lowering medication

McDermott, Mary McGrae; Mazor, Kathleen M.; Reed, George W.; Pagoto, Sherry L.; Graff, Rex; Merriam, Philip A.; Kibbe, Melina R.; Greenland, Philip; Ockene, Judith K.; Olendzki, Barbara C.; Tao, Huimin

doi:10.1177/1358863x09353653

Cited by 12 publications

(19 citation statements)

References 30 publications

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“…Newspaper and radio advertisements, posted signs, community presentations, bulk mailings to men and women aged 65 years and older, and letters mailed to participants with PAD identified in the national Life Line screening program were used for recruitment in Chicago. 9 PAD participants who completed research studies at Northwestern more than 3 months previously were invited to participate. In Worcester, recruitment consisted of mailed letters to patients with PAD, newspaper advertisements, and posted flyers.…”

Section: Setting and Participantsmentioning

confidence: 99%

“…8,9 The institutional review boards of participating medical centers approved the protocol. Participants gave written informed consent.…”

Section: Design Overviewmentioning

confidence: 99%

“…In Worcester, recruitment consisted of mailed letters to patients with PAD, newspaper advertisements, and posted flyers. 9 Inclusion criteria were presence of PAD and an LDL-C ≥ 70 mg/dl. An LDL-C ≥ 70 mg/dl was selected based on recent recommendations regarding LDL-C-lowering therapy in patients at high risk for cardiovascular events.…”

Section: Setting and Participantsmentioning

confidence: 99%

“…9,11 Randomization After baseline testing, eligible participants were randomized using block stratified randomization. Block sizes were three, six, and nine.…”

Section: Medical Historymentioning

confidence: 99%

“…8,9 For each leg, the ABI was calculated by dividing the higher of the dorsalis pedis and posterior tibial pressures by the higher of the brachial pressures.…”

Section: Abi Measurementmentioning

confidence: 99%

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Gender differences in cholesterol-lowering medication prescribing in peripheral artery disease

et al. 2011

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Among 320 patients with lower extremity peripheral artery disease (PAD) and low-density lipoprotein-cholesterol (LDL-C) levels > 70 mg/dl, we determined whether male sex, higher education, and greater self-efficacy for willingness to request therapy from one's physician were associated with increases in LDL-C-lowering medication and achievement of an LDL-C level < 70 mg/dl at 1-year follow-up. Participants were enrolled in a randomized controlled clinical trial to determine whether a telephone counseling intervention can help PAD patients achieve an LDL-C level < 70 mg/ dl, compared to usual care and attention control conditions, respectively. Adjusting for age, race, comorbidities, PAD severity, and other covariates, male sex (odds ratio = 3.33, 95% confidence interval = 1.64 to 6.77, p = 0.001) was associated with a higher likelihood of adding cholesterol-lowering medication during follow-up, but was not associated with achieving an LDL-C < 70 mg/dl (odds ratio = 1.09, 95% confidence interval = 0.55 to 2.18). No associations of education level or self-efficacy with study outcomes were identified. In conclusion, male PAD patients with baseline LDL-C levels ≥ 70 mg/dl were more likely to intensify LDL-C-lowering medication during 1-year follow-up than female PAD patients. Despite greater increases in LDL-C-lowering medication among female PAD patients, there was no difference in the degree of LDL-C lowering during the study between men and women with PAD. Clinical Trial Registration

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Section: Setting and Participantsmentioning

confidence: 99%

“…8,9 The institutional review boards of participating medical centers approved the protocol. Participants gave written informed consent.…”

Section: Design Overviewmentioning

confidence: 99%

Section: Setting and Participantsmentioning

confidence: 99%

“…9,11 Randomization After baseline testing, eligible participants were randomized using block stratified randomization. Block sizes were three, six, and nine.…”

Section: Medical Historymentioning

confidence: 99%

“…8,9 For each leg, the ABI was calculated by dividing the higher of the dorsalis pedis and posterior tibial pressures by the higher of the brachial pressures.…”

Section: Abi Measurementmentioning

confidence: 99%

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Gender differences in cholesterol-lowering medication prescribing in peripheral artery disease

et al. 2011

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Disease acceptance and social support in patients with peripheral vascular diseases treated in the surgical ward

2021

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Each surgery is an emotional stimulus associated with fear of its consequences . The scar after a surgery makes a physical, emotional and psychological mark with symptoms of depression, anxiety, anger and post-traumatic stress (Ngaage & Agius, 2018). Surgical treatment, however justified, is an interference with the physical integrity of the patient. The closer to the procedure, the more the patient considers the dangers arising from it. The patient's mental state becomes changeable, hope appears, but also anxiety associated with the fear of not waking up after surgery, fear of death, complications and anaesthesia, fear of control-loss and complete dependence on staff as well as fear of postoperative pain (Niechwiadowicz -Czapka, 2014;Bedaso & Ayalew, 2019). Studies show that the incidence of pre-operative anxiety in patients waiting for scheduled surgery may be high (47%) and having strong social support significantly reduces its intensity (Bedaso & Ayalew, 2019).Increased anxiety increases the number of complications and reduces the pain threshold (Kim et al., 2014;Marik & Flemmer, 2012).Lack of a support group along with subjective sense of loneliness significantly reduces the mental and physical immunity of the patient (Aliche, Ifeagwazi, Chukwuorji, et al., 2020). Reports from other authors indicate that emotional reactivity in patients qualified for a scheduled surgery is positively associated with pre-operative anxiety only with low level of support from friends and important individuals, but not with moderate or high support (Aliche, Ifeagwazi, & Eze, 2020). Postoperative pain felt by the patient during treatment and recovery, in both acute and chronic diseases, is one of the factors worsening the quality of life and causing less disease accep-

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Activating Peripheral Arterial Disease Patients to Reduce Cholesterol: A Randomized Trial

McDermott

Reed

Greenland

et al. 2011

The American Journal of Medicine

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Background Peripheral arterial disease patients are less likely than other high-risk patients to achieve ideal low density lipoprotein cholesterol (LDL-cholesterol) levels. This randomized controlled trial assessed whether a telephone counseling intervention, designed to help peripheral arterial disease patients request more intensive cholesterol lowering therapy from their physician, achieves lower LDL-cholesterol levels than two control conditions. Methods 355 peripheral arterial disease participants with baseline LDL-cholesterol ≥ 70 mg/dl were enrolled. The primary outcome was change in LDL-cholesterol level at twelve-month follow-up. There were three parallel arms: telephone counseling intervention, attention control condition, and usual care. The intervention consisted of patient-centered counseling, delivered every six weeks, encouraging participants to request increases in cholesterol-lowering therapy from their physician. The attention control condition consisted of telephone calls every six weeks providing information only. The usual care condition participated in baseline and follow-up testing. Results At 12-month follow-up, participants in the intervention improved their LDL-cholesterol level, compared to those in attention control (−18.4 mg/dl vs. −6.8 mg/dl, p= 0.010) but not compared to those in usual care (−18.4 mg/dl vs. −11.1 mg/dl, p= 0.208). Intervention participants were more likely to start a cholesterol-lowering medication or increase their cholesterol-lowering medication dose than those in the attention control (54% vs. 18%, p=0.001) and usual care (54% vs. 31%, P<0.001) conditions. Conclusion Telephone counseling that helped peripheral arterial disease patients request more intensive cholesterol-lowering therapy from their physician achieved greater LDL-cholesterol declines than an attention control arm that provided health information alone.

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Attitudes and behavior of peripheral arterial disease patients toward influencing their physician’s prescription of cholesterol-lowering medication

Cited by 12 publications

References 30 publications

Gender differences in cholesterol-lowering medication prescribing in peripheral artery disease

Gender differences in cholesterol-lowering medication prescribing in peripheral artery disease

Disease acceptance and social support in patients with peripheral vascular diseases treated in the surgical ward

Activating Peripheral Arterial Disease Patients to Reduce Cholesterol: A Randomized Trial

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