Introduction: Herbal medicine is a common method for symptom relief and treatment because of its ample availability and lack of regulation on its prescription. However, herbal use is associated with adverse effects, drug interaction, and sometimes life-threatening complications. During the coronavirus disease (COVID-19) pandemic, people shifted toward herbs when modern medical field failed to discover a treatment or immunization early in the course of the disease. Based on expert consensus, herbal medicine was recommended in Eastern countries, although trials were still ongoing. Methods: A descriptive web-based anonymous survey was created and distributed online all-over Saudi Arabia to gather information on commonly used herbs, knowledge, and attitude towards them among general population (GP) and health care workers (HCWs).Results: Although natural product use was high among GPs, both groups used similar herbs, reflecting cultural tradition and beliefs. However, GPs show better knowledge and attitude about herbal medicine than HCWs. Conclusion: Mental exhaustion during the COVID-19 pandemic and a lack of medicine-based evidence might influence HCW’s trust and knowledge on herbal medicine. Therefore, research and educational courses on herbal medicine for all medical practitioners are needed for proper counseling, thereby reducing risk and ensuring patient safety.