Since 2019, Cyprus has universally implemented the EHR as part of its General Health System (GHS). Between October and December 2022, a cross-sectional study was conducted to investigate the opinions and attitudes of EHR users using an electronic self-report questionnaire. 429 personal and outpatient doctors from all Cypriot Provinces participated in the survey. In the context of the research, all ethical and ethical principles were observed. The average score of the scale "Efficiency in Practicing the Tasks of the Clinical Project when Using the EHR" is 57.4/100, a value that indicates a moderate degree of efficiency of the EHR in the practice of the clinical work. The younger the age, the more positive the user efficiency rating. The shorter the work experience, the more positive the user efficiency rating. The greater the familiarity with the use of PCs and ICT, the more positive the degree of efficiency of the users. The greater the education/training, the more positive the user efficiency rating. The greater the familiarity with the use of the EHR, the more positive the degree of efficiency of the users. The greater the familiarity with the support from the Health Insurance Organization of Cyprus, the more positive the user efficiency rating. In order to fulfill the strategic goals of Cyprus for eHealth, within the European framework health policymakers should proceed with improvement interventions in the context of the implementation of EHR in the GHS. User training and support and equal access for all other health professionals are essential components.