“…Alternatively, lack of adherence to clinical practice guidelines might stem from identified barriers such as lack of faith in the results of randomized clinical trials, negative community attitudes regarding OST, philosophical opposition to treating Bdrug addiction with drugs^, administrative and pharmacy/ formulary barriers at the facilities where the clinics are operating, lack of staff, qualified prescribing clinicians, or funding, low demand or priority, lack of confidence in effectiveness, [21][22][23] or patient preferences concerning methadone treatment. 24,25 If barriers limit guideline adherence, and guideline adherence is important for optimizing treatment outcomes, then treatment outcomes at clinics that more strictly adhere to clinical practice guidelines should be superior.…”