Objectives: Prevalence rates of death by euthanasia (EUT) and physician-assisted suicide (PAS) have considerably increased in older adults, and public debates on these practices are still taking place. In this context, it seemed important to conduct a systematic review of the predictors (demographic, physical, psychological, social, quality of life, religious or existential) associated with attitudes toward, wishes and requests for, as well as death by EUT/PAS among individuals aged 60 years and over. Method: The search for quantitative studies in PsycINFO and MEDLINE databases was conducted three times until April 2018. Articles of probable relevance (n = 327) were assessed for eligibility. Studies that only presented descriptive data (n = 306) were excluded. Results: The review identified 21 studies with predictive analyses, but in only 4 did older adults face actual end-of-life decision making. Most studies (17) investigated attitudes toward EUT/PAS (9 through various hypothetical scenarios). Younger age, lower religiosity, higher education and socioeconomic status, were the most consistent predictors of endorsement of EUT/PAS. Findings were heterogeneous with regard to physical, psychological and social factors. Findings were difficult to compare across studies because of the large variety of outcomes measures and sample characteristics. Conclusion: Future studies should adopt common and explicit definitions of these concepts, as well as mixed longitudinal research designs that would allow for better consideration of various personal and social factors, and their interplays, on the decisionmaking process with regard to EUT/PAS.