1998
DOI: 10.1073/pnas.95.19.11336
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Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions

Abstract: Attractin is a normal human serum glycoprotein of 175 kDa that is rapidly expressed on activated T cells and released extracellularly after 48-72 hr. We have cloned attractin and find that, as in its natural serum form, it mediates the spreading of monocytes that become the focus for the clustering of nonproliferating T lymphocytes. There are two mRNA species with hematopoietic tissue-specific expression that code for a 134-kDa protein with a putative serine protease catalytic serine, four EGF-like motifs, a C… Show more

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Cited by 133 publications
(122 citation statements)
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“…A predicted Caenorhabditis elegans protein, F33C8.1, is also homologous to attractin and is a transmembrane rather than a soluble protein (2). These results lead to the proposition that there exists a human membrane attractin in addition to the secreted form.…”
mentioning
confidence: 71%
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“…A predicted Caenorhabditis elegans protein, F33C8.1, is also homologous to attractin and is a transmembrane rather than a soluble protein (2). These results lead to the proposition that there exists a human membrane attractin in addition to the secreted form.…”
mentioning
confidence: 71%
“…Germ-line mutations in the DNA-binding domain of Ikaros lead to animals devoid of T cells, B cells, and NK cells. There are three sites for NF-AT, nevertheless there is no evidence of an up-regulation of attractin mRNA after activation (2). Additional evidence that the role of NF-AT may be limited is that stimulation with phorbol 12-myristate 13-acetate͞ionomycin is known to up-regulate NF-AT activity, but such stimulation does not induce attractin expression.…”
Section: Discussionmentioning
confidence: 98%
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“…Administration of chemical inhibitors of DPP IV activity leads to increased levels of GLP-1 in the circulation and causes enhanced insulin secretion and improved glucose tolerance in normal and diabetic animals (13)(14)(15)(16). However, the precise molecular target of these pharmacological inhibitors has not been identified, in part because of the multiplicity of enzymes exhibiting DPP IV-like activity (17)(18)(19)(20)(21). The aim of this study was to clarify the physiological role of CD26 and determine its contribution to blood glucose control.…”
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confidence: 99%