Attractive and permissive activities of semaphorin 5A toward dorsal root ganglion axons in higher vertebrate embryos

Masuda, Tomoyuki; Sakuma, Chie; Yaginuma, Hiroyuki; Taniguchi, Masahiko

doi:10.4161/19336918.2014.972770

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…The Sema5A-induced promoting effect on axonal arbor extension of enteric neurons is consistent with previous studies reporting a permissive activity of Sema5A on axon elongation of dorsal root ganglia and in the diencephalon. 15 , 20 The Sema5A-induced effects in the distal region of the axonal arborization could have consequences on the maturation of ENS functional network. The terminal part of the axonal arbor contains numerous branches emanating from the axon shaft.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, mice invalidated for Sema5A exhibit ASD-like behaviors and several brain abnormalities including defects in axonal elongation and synaptic activity. 14 , 15 Moreover, deletion of Plexin A1 or Plexin A2 receptors, two receptors for Sema5A, alters axonal patterning and synaptogenesis. 16 , 17 Regarding the gastrointestinal tract, Sema5A deficiency in mice induced increased defecation suggesting the implication of Sema5A in gut functions potentially through modulation of ENS activity.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The regulation of enteric neuron connectivity by semaphorin 5A is affected by the autism-associated S956G missense mutation

Le Dréan,

Le Berre-Scoul,

Paillé

et al. 2024

iScience

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The regulation of enteric neuron connectivity by semaphorin 5A is affected by the autism-associated S956G missense mutation

Le Dréan,

Le Berre-Scoul,

Paillé

et al. 2024

iScience

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Transmembrane semaphorins, forward and reverse signaling: have a look both ways

Battistini

Tamagnone

2016

Cell. Mol. Life Sci.

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Semaphorins are signaling molecules playing pivotal roles not only as axon guidance cues, but are also involved in the regulation of a range of biological processes, such as immune response, angiogenesis and invasive tumor growth. The main functional receptors for semaphorins are plexins, which are large single-pass transmembrane molecules. Semaphorin signaling through plexins-the "classical" forward signaling-affects cytoskeletal remodeling and integrin-dependent adhesion, consequently influencing cell migration. Intriguingly, semaphorins and plexins can interact not only in trans, but also in cis, leading to differentiated and highly regulated signaling outputs. Moreover, transmembrane semaphorins can also mediate a so-called "reverse" signaling, by acting not as ligands but rather as receptors, and initiate a signaling cascade through their own cytoplasmic domains. Semaphorin reverse signaling has been clearly demonstrated in fruit fly Sema1a, which is required to control motor axon defasciculation and target recognition during neuromuscular development. Sema1a invertebrate semaphorin is most similar to vertebrate class-6 semaphorins, and examples of semaphorin reverse signaling in mammalians have been described for these family members. Reverse signaling is also reported for other vertebrate semaphorin subsets, e.g. class-4 semaphorins, which bear potential PDZ-domain interaction motifs in their cytoplasmic regions. Therefore, thanks to their various signaling abilities, transmembrane semaphorins can play multifaceted roles both in developmental processes and in physiological as well as pathological conditions in the adult.

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Transmembrane semaphorins: Multimodal signaling cues in development and cancer

Gurrapu

Tamagnone

2016

Cell Adhesion & Migration

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Semaphorins constitute a large family of membrane-bound and secreted proteins that provide guidance cues for axon pathfinding and cell migration. Although initially discovered as repelling cues for axons in nervous system, they have been found to regulate cell adhesion and motility, angiogenesis, immune function and tumor progression. Notably, semaphorins are bifunctional cues and for instance can mediate both repulsive and attractive functions in different contexts. While many studies focused so far on the function of secreted family members, class 1 semaphorins in invertebrates and class 4, 5 and 6 in vertebrate species comprise around 14 transmembrane semaphorin molecules with emerging functional relevance. These can signal in juxtacrine, paracrine and autocrine fashion, hence mediating long and short range repulsive and attractive guidance cues which have a profound impact on cellular morphology and functions. Importantly, transmembrane semaphorins are capable of bidirectional signaling, acting both in "forward" mode via plexins (sometimes in association with receptor tyrosine kinases), and in "reverse" manner through their cytoplasmic domains. In this review, we will survey known molecular mechanisms underlying the functions of transmembrane semaphorins in development and cancer.

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Attractive and permissive activities of semaphorin 5A toward dorsal root ganglion axons in higher vertebrate embryos

Cited by 4 publications

References 16 publications

The regulation of enteric neuron connectivity by semaphorin 5A is affected by the autism-associated S956G missense mutation

The regulation of enteric neuron connectivity by semaphorin 5A is affected by the autism-associated S956G missense mutation

Transmembrane semaphorins, forward and reverse signaling: have a look both ways

Transmembrane semaphorins: Multimodal signaling cues in development and cancer

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