Attributes of Bio‐Oss<sup>®</sup> and Moa‐Bone<sup>®</sup> graft materials in a pilot study using the sheep maxillary sinus model

Smith, Michael; Duncan, Warwick; Coates, Dawn

doi:10.1111/jre.12490

Cited by 21 publications

(21 citation statements)

References 46 publications

(96 reference statements)

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“…In a case report, a biopsy taken 12 months after maxillary sinus grafting with Bio-Oss revealed the persistence of particles with no evidence of resorption. 67 In this context, Smith et al 77 also revealed that the MNGCs at the surfaces of Bio-Oss were TRAP-positive but no resorption lacunae have been detected.…”

Section: Resorbability Of Xenogeneic Bone Substitutesmentioning

confidence: 96%

Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration

et al. 2018

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Xenogeneic bone substitute materials are widely used in oral implantology. Prior to their clinical use, purification of the former bone tissue has to be conducted to ensure the removal of immunogenic components and pathogens. Different physicochemical methods are applied for purification of the donor tissue, and temperature treatment is one of these methods. Differences in these methods and especially the application of different temperatures for purification may lead to different material characteristics, which may influence the tissue reactions to these materials and the related (bone) healing process. However, little is known about the different material characteristics and their influences on the healing process. Thus, the aim of this mini-review is to summarize the preparation processes and the related material characteristics, safety aspects, tissue reactions, resorbability and preclinical and clinical data of two widely used xenogeneic bone substitutes that mainly differ in the temperature treatment: sintered (cerabone) and non-sintered (Bio-Oss) bovine-bone materials. Based on the summarized data from the literature, a connection between the material-induced tissue reactions and the consequences for the healing processes are presented with the aim of translation into their clinical application.

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Section: Resorbability Of Xenogeneic Bone Substitutesmentioning

confidence: 96%

Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration

et al. 2018

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“…The type of NB was mostly lamellar, suggesting that the grafted site was relatively mature. In a recent study using the same model (Smith et al, ), grafted sinuses with BBM demonstrated a similar histologic appearance after 12 weeks of healing. Alayan, Vaquette, Saifzadeh, Hutmacher, and Ivanovski () documented an increase in the lamellar bone fraction from 8 to 16 weeks of healing.…”

Section: Discussionmentioning

confidence: 78%

“…Pure collagen as a sponge was used as a negative control. The study objective was to analyze the outcomes of this sinus grafting histologically and histomorphometrically, using a well‐established sheep animal model (Haas et al, ; Smith et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Among these, Bio-Oss ® (bovine bone matrix [BBM]) is a deproteinized material of bovine origin, which has become widely used in clinical practice, shows slow-resorbing turnover rates, and is able to maintain the regenerative space even for a long period after SFE. There is a convincing body of literature documenting the successful use of BBM in SFE (Wu, Li, & Lin, 2016) and this material has often been used as a positive control when new products have been tested in preclinical and clinical trials (Cordaro et al, 2008;Jensen, Bornstein, Dard, Bosshardt, & Buser, 2009;Ozyuvaci, Bilgic, & Firatli, 2003;Smith, Duncan, & Coates, 2018). However, BBM in its particulated state may be difficult to manipulate intrasurgically.…”

Section: Introductionmentioning

confidence: 99%

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Biphasic calcium phosphate and polymer‐coated bovine bone matrix for sinus grafting in an animal model

et al. 2019

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Autogenous bone grafting requires a donor site and may lose substantial volume during remodeling. Several bone replacement materials (BRMs) are under development to overcome these limitations, especially for indications for minimally intervention surgeries. The objective of our study was to assess the potential of an equine collagen cone reinforced with biphasic calcium phosphate (CC‐BCP) particles and deproteinized bovine bone matrix (BBM) coated with polylactic acid, and poly‐ε‐caprolactone copolymer (BBM‐PCC) and then to compare the outcomes with a deproteinized BBM and an equine CC without a filler in a sheep sinus grafting model in the Elleven female sheep were selected. Two experimental sites on each side of the animals were prepared using an extraoral approach for maxillary sinus wall. The four treatments were performed in each animal through a standardized 10‐mm access window. While the BBM access was covered with a collagen membrane, all other sites were closed with an equine collagen membrane. All animals were euthanized after 16 weeks. New bone (NB), residual graft particles, and connective tissue were measured in undemineralized resin‐embedded sections. As a result, one sheep did not survive the surgery. All sites in the remaining 10 sheep healed uneventfully. All CC and BBM‐PCC grafts resorbed and failed to augment the sinuses. BBM and CC‐BCP, in contrast, showed some histologic evidence of NB and surgical site augmentation. The NB fraction in the latter two groups accounted for 10 ± 9 and 4 ± 5%, respectively (p > 0.05). In conclusion, BBM‐PCC and collagen cone performed poorly for sinus floor augmentation, while deproteinised BBM and reinforced collagen cone demonstrated comparable outcomes

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“…One of the most documented osteoconductive materials used for bone grafts, is anorganic bovine bone (ABB) hydroxyapatite: Bio-Oss® (Geistlich Pharma Wolhusen Switzerland) [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Bone Quality Obtained in Sinus Lifting with Anorganic Bovine Bone. A CBCT Study

Melisa¹,

Constanza²,

Carlos³

2020

Int J Oral Craniofac Sci

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Objective: Quantitatively assess bone density in maxillary sinus lifting with ABB (Bio-Oss®), using Cone-Beam computed tomography 6 months after surgery. Material and methods:A retrospective observational study was conducted between February 2018 and February 2019 on 33 Cone-Beam tomographic studies of 29 adult patients of both genders, with maxillary sinus fl oor lift, using Bio-Oss® small particles ( 0.25-1um), large particles (1-2um) or a 50-50 % mix of both, always using Bio-Gide® membranes, in order to measure bone density through Hounsfi eld Units (UH) after 6 months of healing. Results:The average density of the grafted sinuses was 586 ± 238 HU, corresponding to Type II-III bone. Gender (p = 0.079) and Residual bone (p = 0.681) showed no signifi cant differences, while Age (p = 0.015) and Particles Size (p = 0.002; p <0.05), were signifi cant. The highest tomographic density was obtained in patients older than 65 years; and in mixed particles size grafts. Conclusion:The bone density obtained after maxillary sinus lifting with Bio-Oss shows quantitative values similar to those of type II-III bone, providing a high degree of predictability for implant placement 6 months after the intervention.

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Attributes of Bio‐Oss^® and Moa‐Bone^® graft materials in a pilot study using the sheep maxillary sinus model

Cited by 21 publications

References 46 publications

Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration

Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration

Biphasic calcium phosphate and polymer‐coated bovine bone matrix for sinus grafting in an animal model

Bone Quality Obtained in Sinus Lifting with Anorganic Bovine Bone. A CBCT Study

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Attributes of Bio‐Oss® and Moa‐Bone® graft materials in a pilot study using the sheep maxillary sinus model

Cited by 21 publications

References 46 publications

Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration

Purification processes of xenogeneic bone substitutes and their impact on tissue reactions and regeneration

Biphasic calcium phosphate and polymer‐coated bovine bone matrix for sinus grafting in an animal model

Bone Quality Obtained in Sinus Lifting with Anorganic Bovine Bone. A CBCT Study

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Product

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Attributes of Bio‐Oss^® and Moa‐Bone^® graft materials in a pilot study using the sheep maxillary sinus model