Attributes of brain metastases from breast and lung cancer

“…Imaging findings, especially magnetic resonance imaging (MRI) features of BM have been described in detail previously [2][3][4]. According to the literature, BM from different primary tumors also showed different MRI patterns [2,3].…”

Section: Introductionmentioning

confidence: 96%

Comparison of diffusion-weighted imaging findings in brain metastases of different origin

et al. 2015

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“…Metastases have more distinct borders in comparison to gliomas, and may have surrounding vasogenic edema that is disproportionate to the size of the lesion. 90 Cerebellar involvement is more common in breast cancer, and lung cancer is generally associated with larger amounts of surrounding vasogenic edema when compared with breast cancer. 90 Melanoma has unique imaging features that may be highly suggestive of the diagnosis.…”

Section: Tumormentioning

confidence: 99%

“…90 Cerebellar involvement is more common in breast cancer, and lung cancer is generally associated with larger amounts of surrounding vasogenic edema when compared with breast cancer. 90 Melanoma has unique imaging features that may be highly suggestive of the diagnosis. Non-hemorrhagic melanoma may appear hyperintense on T1-weighted images and isointense to hypointense on T2-weighted images sec-ondary to the intrinsic paramagnetic effects of melanin pigment.…”

Section: Tumormentioning

confidence: 99%

Neuroimaging of the Afferent Visual System

Mallery

Prasad

2013

Semin Neurol

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Neuroimaging studies provide a useful tool for the clinician evaluating a patient with visual loss. In this review, we discuss the use of magnetic resonance imaging (MRI), computed tomography (CT), orbital ultrasound, and optical coherence tomography (OCT) for evaluating causes of visual loss affecting the afferent visual system. The imaging characteristics of diseases affecting the optic nerve, orbit, sellar and parasellar region, optic tracts, and retrogeniculate visual pathways will be discussed.

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“…Hengel et al reported that BM from lung cancer are more likely to show an edema at >3–4 cm in diameter compared to BM from breast cancer, but the size above which a BM initiates VE formation has not been further studied [14]. Since we demonstrated that the general minimum cut-off value for the presence of VE is a BM diameter of 9.4 mm, but differs between primary sites, we hypothesize that the above-mentioned mechanisms leading to an edema are histology-specific.…”

Section: Discussionmentioning

confidence: 99%

Edema is not a reliable diagnostic sign to exclude small brain metastases

et al. 2017

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No prior systematic study on the extent of vasogenic edema (VE) in patients with brain metastases (BM) exists. Here, we aim to determine 1) the general volumetric relationship between BM and VE, 2) a threshold diameter above which a BM shows VE, and 3) the influence of the primary tumor and location of the BM in order to improve diagnostic processes and understanding of edema formation. This single center, retrospective study includes 173 untreated patients with histologically proven BM. Semi-manual segmentation of 1416 BM on contrast-enhanced T1-weighted images and of 865 VE on fluid-attenuated inversion recovery/T2-weighted images was conducted. Statistical analyses were performed using a paired-samples t-test, linear regression/generalized mixed-effects model, and receiver-operating characteristic (ROC) curve controlling for the possible effect of non-uniformly distributed metastases among patients. For BM with non-confluent edema (n = 545), there was a statistically significant positive correlation between the volumes of the BM and the VE (P < 0.001). The optimal threshold for edema formation was a diameter of 9.4 mm for all BM. The primary tumors as interaction term in multivariate analysis had a significant influence on VE formation whereas location had not. Hence VE development is dependent on the volume of the underlying BM and the site of the primary neoplasm, but not from the location of the BM.

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Attributes of brain metastases from breast and lung cancer

Abstract: Brain metastases from lung occur earlier, are more edematous, but fewer in number than those from breast cancers. Cerebellar brain metastases are more frequent in breast cancer.

Cited by 27 publications

References 21 publications

Comparison of diffusion-weighted imaging findings in brain metastases of different origin

Comparison of diffusion-weighted imaging findings in brain metastases of different origin

Neuroimaging of the Afferent Visual System

Edema is not a reliable diagnostic sign to exclude small brain metastases

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