Atypical Antipsychotic Administration During Late Pregnancy: Placental Passage and Obstetrical Outcomes

Abstract

All four antipsychotics demonstrated incomplete placental passage. Quetiapine demonstrated the lowest placental passage of the medications studied. These novel data provide an initial quantification of the placental passage of antipsychotics and fetal exposure in humans, demonstrating significant differences between individual medications.

Neonatal hypoglycaemia following maternal olanzapine therapy during pregnancy: a case report

“…Olanzapine has an in vivo placental passage ratio of 72.2% [Newport et al 2007], and several case reports on its use have described uneventful pregnancies and healthy infants. The largest study to date found that olanzapine did not increase the risk of major congenital malformations, but was associated with a higher maternal BMI, maternal gestational diabetes and low birth weight [Reis and Kallen, 2008].…”

Pharmacotherapy of obsessive-compulsive disorder during pregnancy: a clinical approach

“…72,83 Quetiapine had the lowest placental passage compared with the three medications mentioned above. 84 Despite their limitations, the available studies did not demonstrate an elevated risk. 73 The rate of malformations after fetal exposure to quetiapine is about 3.5%.…”

“…A lack of difference between exposed and non-exposed women has been reported for mean birth weight 71,74,77 and proportion of small for gestational age infants. 74 Moreover, the risk of low birth weight 71,72,84 or proportion of small for gestational age infants was not reported to increase for exposed women. 85 Some authors showed that typical antipsychotics but not SGAs were associated with lower mean birth weight of fetus.…”

“…[81][82][83][84] Interestingly, some studies revealed statistically significant differences in the early termination of pregnancy especially due to social reasons in women using these drugs (9.9-12.2%) compared to control pregnant women (1.3-1.8%). 71,73 Several studies have reported a 1.7-2.5-fold increase in the risk of preterm birth (PTB) with use of antipsychotics.…”

African-American and Latina Women Seeking Public Health Services: Cultural Beliefs regarding Pregnancy, including Medication-taking Behavior

“…Various factors may further contribute to negative birth outcomes such as, the use of medications during pregnancy, the mother's stress level in low-income population, nutritional status, chronic diseases, acute diseases, illicit drug use, domestic violence, depression and environmental factors [14][15][16][17][18][19] .…”