Atypical antipsychotics related metabolic syndrome in bipolar patients

Yumru, Mehmet; Savaş, Haluk A.; Kurt, Erhan; Kaya, Mehmet Cemal; Selek, Salih; Savaş, Esen; Oral, Elif; Atagün, Ilhan

doi:10.1016/j.jad.2006.08.009

Cited by 128 publications

(105 citation statements)

References 30 publications

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“…The overall prevalence of MetS was 27.5% which is similar to the results of the previous studies investigating MetS in bipolar patients (Fagiollini et al, 2005;Yumru et al, 2007;Cardenas et al, 2008;Garcia -Portilla et al, 2008).…”

Section: Principal Findingssupporting

confidence: 88%

Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

Vuksan-Ćusa

Marčinko

Nađ

et al. 2009

Acta Neuropsychiatr.

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Patient with mental illnesses such as schizophrenia and bipolar disorder have an increased prevalence of metabolic syndrome (MetS) and its components compared to general population. Among psychiatric disorders, bipolar disorder ranks highest in suicidality with a relative risk ratio of completed suicide of about 25 compared to the general population.Regarding the biological hypotheses of suicidality, low blood cholesterol level has been extensively explored, although results are still conflicting. The aim of this study was to investigate whether there were differences in the serum cholesterol levels in hospitalized bipolar disorder men patients with history of suicide attempts (N=20) and without suicide attempts (N=20). Additionally, we investigated if there were differences in the prevalence of MetS according to NCEP ATP-III criteria in these two groups of patients. Results of the study indicated significantly lower serum cholesterol levels (p=0.013) and triglyceride levels (p=0.047), in the bipolar disorder men with suicide attempts in comparison to bipolar disorder men without suicide attempts. The overall prevalence of MetS was 11/40 (27.5%). On this particular sample it was higher in the non-attempters 8/20 (40.0%) than in attempters 3/20 (15.0%) bipolar men group, but without statistical significance. Lower concentrations of serum cholesterol might be useful biological markers of suicidality in men with bipolar disorder.

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Section: Principal Findingssupporting

confidence: 88%

Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

Vuksan-Ćusa

Marčinko

Nađ

et al. 2009

Acta Neuropsychiatr.

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show abstract

“…Yumru et al [30] have analyzed the influence of gender on MS (but not its components), failing to find a statistically significant association. However, Mattoo and Singh [31] found a trend of female preponderance for the prevalence of MS across different diagnoses among psychiatric inpatients.…”

Section: Discussionmentioning

confidence: 98%

Assessment of Insulin Resistance and Metabolic Syndrome in Drug Naive Patients of Bipolar Disorder

et al. 2013

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The levels of fasting glucose, fasting insulin, insulin resistance (IR) and the prevalence of metabolic syndrome (MS) in a sample population of bipolar disorder (BPD) patients who were newly diagnosed and psychotropically naïve were assessed and compared with an age, sex and racially matched control population. 55 BPD-I patients (15-65 years) who were non-diabetic, nonpregnant, and drug naïve for a period of at least 6 months were included in the study. Diagnosis was made using the structured clinical interview for DSM-IV axis I disorders (SCID IV). IR was assessed using homeostasis model of insulin resistance (HOMA-IR); MS was defined according to National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III). Data were compared with 25 healthy controls. BPD patients had significantly higher mean levels of fasting plasma insulin (13.2 ± 9.2 vs. 4.68 ± 3.1 lIU/ ml, p \ 0.05), postprandial plasma insulin (27.2 ± 14.5 vs. 18.1 ± 9.3 lIU/ml, p \ 0.05) and a higher value of HOMA-IR (3.16 ± 2.2 vs. 1.19 ± 0.8, p \ 0.05) when compared to the controls. A significantly higher proportion of patients of BPD compared to controls were manifesting levels of fasting plasma glucose, serum triglyceride and blood pressure higher than the cut off while waist circumference and serum HDL cholesterol failed to show any significant difference in the proportion. There was a significantly higher proportion of prevalence of IR between BPD cases and controls (26/55 vs. 2/25, z value 9.97, p \ 0.05) while there was no significant difference in proportion of prevalence of MS between these two groups. Within BPD patients, logistic regression analysis showed that age, sex or current mood status (depressed/ manic) were not significantly predictive of presence or absence of MS or increased IR.

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“…Previous studies on the prevalence of MetS in bipolar patients found 30% and 49% prevalence of MetS in US bipolar patients (Fagiolini et al, 2005;Cardenas et al, 2008), 32% prevalence of MetS in Turkish bipolar patients (Yumru et al, 2007) and 22.4% in Spanish bipolar patients (Garcia-Portilla et al, 2008). The etiology associated with this increased risk of MetS in bipolar disorder is unknown.…”

Section: Introductionmentioning

confidence: 92%

Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

Vuksan-Ćusa

Marčinko

Nađ

et al. 2009

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Atypical antipsychotics related metabolic syndrome in bipolar patients

Cited by 128 publications

References 30 publications

Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

Assessment of Insulin Resistance and Metabolic Syndrome in Drug Naive Patients of Bipolar Disorder

Differences in cholesterol and metabolic syndrome between bipolar disorder men with and without suicide attempts

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