Atypical Borrelia garinii infection in an immunocompromised patient mimicking high-grade lymphoma

Eiferman, Victor; Guenno, G. Le; Boiret-Dupré, Nathalie; Barrès, B.; Luciani, Léa; Fournier, Pierre

doi:10.1016/j.ijid.2022.04.062

Cited by 4 publications

(1 citation statement)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Specific to tick-borne diseases, Maraspin et al reported that immunocompromised patients more commonly present with disseminated erythema migrans and extracutaneous manifestations of Lyme borreliosis [246]. Eiferman et al reports a case of Borreliosis mimicking high-grade transformation of lymphoma in a patient with a background of lymphoma [247]. Other atypical, potentially life-threatening manifestations of borreliosis, anaplasmosis, and rickettsioses have been reported amongst transplant patients as well [248].…”

Section: Travel Medicine: When To Consider Tick-borne Diseasesmentioning

confidence: 99%

Revenge of the Tick: Tick-Borne Diseases and the Eye in the Age of Climate Change and Globalisation

Lau

Chan

et al. 2022

Zoonotic Diseases

View full text Add to dashboard Cite

Climate change has contributed to changes in disease transmission. In particular, zoonoses such as tick-borne diseases are occurring in areas previously unsuitable for tick survival, with spread to non-endemic areas rising. Ophthalmic manifestations of tick-borne diseases are rare. Often overlooked, diagnosis requires awareness and a high level of suspicion, which may delay treatment. This review provides a comprehensive overview of ocular disease associated with ticks so that management protocols for patients can be designed and implemented. A narrative literature review was conducted. The current literature includes case series, case reports, and literature reviews. Ocular manifestations of tick-borne diseases include adnexal manifestations, conjunctivitis, keratitis, cranial nerve palsies, optic nerve disease, uveitis, exudative retinal detachment, and panophthalmitis, which may occur in isolation or as part of a systemic process. As there is no one constellation of ocular symptoms and signs diagnostic of tick-borne eye diseases, a systematic approach is recommended with particular attention to significant travel and exposure history. In this review, we identify significant risk factors and propose management strategies for afflicted patients to improve treatment outcomes while maintaining cost-effectiveness. Ophthalmologists and generalists will benefit from increased awareness of ocular manifestations of tick-borne diseases in the age of modern travel and climate change.

show abstract

Section: Travel Medicine: When To Consider Tick-borne Diseasesmentioning

confidence: 99%

Revenge of the Tick: Tick-Borne Diseases and the Eye in the Age of Climate Change and Globalisation

Lau

Chan

et al. 2022

Zoonotic Diseases

View full text Add to dashboard Cite

show abstract

Erythropoietin/immunosuppressants/rituximab

2022

Reactions Weekly

View full text Add to dashboard Cite

Peripheral Blood Smears Distinguish Infective Fever after CAR-T Therapy

He,

Peng,

Yang

et al. 2023

Front. Biosci. (Landmark Ed)

View full text Add to dashboard Cite

Background: Chimeric antigen receptor (CAR) T-cell therapy carries the risk of inducing severe and life-threatening toxicities such as cytokine release syndrome (CRS), neurotoxicity, and infection. Although CRS and infections have similar symptoms, their treatment strategies differ, and early diagnosis is very important. For CRS and infections, the fastest detection time currently takes more than 24 h, so a quick and simple method to identify a fever after CAR T-cell infusion is urgently needed. Methods: We enrolled 27 patients with recurrent fever treated with different types of CAR T-cells, including cluster of differentiation (CD) 7, CD19, CD22, and CD19-CD22 bicistronic CAR T-cells, and evaluated the infection events occurring in these patients. We detailed the morphology of CAR T-cells in peripheral blood smears (PBS) and reported the infection events, CAR transgene copy number, and inflammatory indicators within the first month after treatment. Results: Similar morphological characteristics were observed in the PBS of different CAR T-cells, namely, enlarged cell bodies, deep outside and shallow inside basophilic blue cytoplasm, and natural killer (NK) cell-like purplish red granules. There were ten infections in nine of the twenty-seven patients (33%). The percentage of atypical lymphocytes in PBS was significantly associated with CAR transgene copy number and absolute lymphocyte count in all patients. The atypical lymphocyte percentage was significantly higher in the non-infection group. Conclusions: In conclusion, the unique morphology of CAR T-cells in PBS can be used to evaluate CAR T-cell kinetics and provide reliable evidence for the rapid early identification of fever after CAR T-cell infusion. Clinical Trial Registrations: ChiCTR-OPN-16008526; ChiCTR-OPN-16009847; ChiCTR2000038641; NCT05618041; NCT05388695.

show abstract

Atypical Borrelia garinii infection in an immunocompromised patient mimicking high-grade lymphoma

Cited by 4 publications

References 16 publications

Revenge of the Tick: Tick-Borne Diseases and the Eye in the Age of Climate Change and Globalisation

Revenge of the Tick: Tick-Borne Diseases and the Eye in the Age of Climate Change and Globalisation

Erythropoietin/immunosuppressants/rituximab

Peripheral Blood Smears Distinguish Infective Fever after CAR-T Therapy

Contact Info

Product

Resources

About