Atypical Canine Mammary Adenoma Characterized by Cystic Ducts Comprising a Single Layer of Basaloid Cells with Myoepithelial Differentiation

Yasuno, Kyohei; Kobayashi, Ryosuke; Mineshige, Takayuki; Sugahara, Go; Nagata, Masahiko; Kamiie, Junichi; Shirota, Kinji

doi:10.1292/jvms.13-0016

Cited by 4 publications

(2 citation statements)

References 14 publications

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“…On the background of squamous metaplasia were revealed isolated clusters of large «foamy» cells associated with basaloid reserve cells, similar to sebaceous glands. The expression of p63 in both sebaceous basaloid reserve cells and myoepithelial cells, and their structural continuity in the tumour tissue, indicates a common origin of these two components (Yasuno et al, 2013).…”

Section: Clinical and Pathomorphological Features Of Mastopathy In Dogsmentioning

confidence: 92%

Canine mastopathy (Overview)

Bilyi,

Khomutenko

2022

TAVM

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The etiological factors, pathogenesis and clinical and pathomorphological features of mastitis in dogs remain poorly understood, due to isolated, multidirectional studies on a small number of animals. Fibrocystic disease is diagnosed in different species of animals -small domestic, productive and laboratory animals. The clinical signs are not pathognomonic and an atypical course of the disease is possible. The potential role of mastopathy in the development of cancer has been proven, but the pathogenesis of functional dysplasia of mammary tissue, and the internal and external factors that may initiate further neoplastic transformation, remain poorly understood. Mastopathy in bitches is widespread and accounts for 8 to 30% of benign mammary gland neoplasms. Susceptibility varies considerably according to the distribution of breeds in the region. Compared to neoplasms (where the highest incidence is in animals over 7 years of age), mastitis peaks in 5-6-year-old dogs. A hormonal imbalance has been shown to be a direct cause of fibrocystic disease in bitches, and this has been experimentally confirmed in rats. The prognostic significance of estrogen and progesterone receptor expression was clarified. The importance of chronic inflammation in the pathogenesis of fibrocystic disease was shown. A high risk of mastopathy in overweight bitches has been established. Diabetes is a potential risk factor for fibrocystic disease, but further research is needed to clarify the patterns. The prospect for further research is to identify prognostic factors and key biological mechanisms to predict the course of the disease and to develop pathogenetically sound treatment protocols.

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Section: Clinical and Pathomorphological Features Of Mastopathy In Dogsmentioning

confidence: 92%

Canine mastopathy (Overview)

Bilyi,

Khomutenko

2022

TAVM

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“…To define the localization of mammary acini and ducts in mammary tissues from nulliparous animals, α-smooth muscle actin (SMA)-expressing cells (i.e., myoepithelial cells surrounding the acini and ducts) were detected by immunohistochemistry with anti-SMA antibody (clone 1A4; Dako A/S, Glostrup, Denmark) as described previously (Yasuno et al, 2013). The mammary tissue specimens were also stained with hematoxylin and eosin.…”

Section: Immunohistochemistry Of Mammary Glandmentioning

confidence: 99%

Dose-dependent acceleration in the delayed effects of neonatal oral exposure to low-dose 17α-ethynylestradiol on reproductive functions in female Sprague-Dawley rats

Shirota¹,

Kawashima²,

Nakamura³

et al. 2015

J. Toxicol. Sci.

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-Xenoestrogen exposure during the critical period of sexual differentiation of the brain causes delayed effects on female reproduction. We investigated the internal dose of orally administered ethynylestradiol (EE) during the critical period and its delayed effects by administering 0 (vehicle control), 0.4, or 2 μg/kg EE to female Sprague-Dawley rats for 5 days from postnatal day (PND) 1. Determination of serum EE level 24 hr after the initial dosing and 6 and 24 hr after the final dosing of 2 μg/kg indicated that the administered EE entered the circulation and cleared after every administration. Although the treatment did not affect physical development, including growth, eyelid opening, and vaginal opening, the estrous cycle was arrested from postnatal week (PNW) 12 even with 0.4 μg/kg EE, with an inverse correlation between doses and arresting ages. Although ovarian morphology at PNW 22-23 indicated that the treatment caused long-term anovulation and cystic follicle formation, the number of primordial follicles at PNW 22-23 was similar among the groups. Because this number was lower than that at PND 10 in all groups, primordial follicles may have been consumed under long-term anovulation. The treatment also caused other abnormalities, including mammary gland hyperplasia, increase in pituitary and liver weights, and decrease in the uterine weight. Because the highest circulating EE level in the 2 μg/kg-treated neonates is considered to be comparable to the physiological range of estradiol-17β, we concluded that a slight increase in the circulating estrogens during the neonatal period exerts irreversible delayed effects.

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Canine Breast Carcinomas: Recent Advances in Diagnostic and Treatment Strategies

Rath,

Jaiswal,

Pal

et al. 2024

Advanced Therapeutics

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Breast cancer in canines is one of the leading causes of death globally due to client misinterpretation and improper diagnosis and treatment. In past centuries, the diagnosis and treatment of breast carcinoma in dogs followed conventional techniques adopted from human oncology. However, with increasing demand and scientific advancements in the upcoming future, there is an emerging necessity to modernize the diagnostic and treatments in canine breast cancer (CBC) patients. This review explores recent advances in diagnostic techniques and novel therapeutic approaches such as adjuvant‐based targeted therapy, nanomaterial therapy, immune‐based therapy, adoptive cell therapy, tumor vaccine, oncolytic virotherapy, and the use of noncoding RNAs in CBCs. In addition, the review discusses the healthcare policies aimed at improving diagnostic and therapeutic efficacy and future directions for translation from human oncology into veterinary oncology. By adopting these modern strategies, the quality of care can be significantly enhanced by translating them into practical applications with better outcomes and improved survival rates for canine patients.

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Atypical Canine Mammary Adenoma Characterized by Cystic Ducts Comprising a Single Layer of Basaloid Cells with Myoepithelial Differentiation

Cited by 4 publications

References 14 publications

Canine mastopathy (Overview)

Canine mastopathy (Overview)

Dose-dependent acceleration in the delayed effects of neonatal oral exposure to low-dose 17α-ethynylestradiol on reproductive functions in female Sprague-Dawley rats

Canine Breast Carcinomas: Recent Advances in Diagnostic and Treatment Strategies

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