2024
DOI: 10.1101/2024.07.03.601867
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Atypical chemokine receptor 3 regulates synaptic removal in disease astrocytes

V Giusti,
J Park,
E Giusto
et al.

Abstract: Astrocytes participate in the clearance of obsolete or unwanted neuronal synapses. However, the molecular machinery recruited for the recognition of synapses is not fully clarified, especially in pathological conditions. Here, we investigated the phagocytic process through individual gene silencing using a druggable gene library. Our study demonstrates that astrocyte-mediated synapse engulfment is regulated by the Atypical chemokine receptor 3 (Ackr3). Mechanistically, we have shown that Ackr3 recognizes phosp… Show more

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