Atypical clear cell sarcoma of the pleura presenting as large pleural effusion with 22q12 abnormality: A challenging case with twists and turns

Zhang, Xiaoming; Zhang, Paul J.; Sussman, Robyn T.; Litzky, Leslie A.; Kucharczuk, John C.; Deshpande, Charuhas

doi:10.1016/j.ehpc.2021.200489

Cited by 2 publications

(10 citation statements)

References 63 publications

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“…Overall, the clinical presentation of such cases was heterogeneous, and some sarcomas were initially misdiagnosed because several aspects, such as clinical factors, localization of the lesion, and histologic appearance, suggested a malignant melanoma [9,[17][18][19][20][21][22][23][24][25][26][27][28][32][33][34][35][39][40][41]. In some cases, the clinician considered other diagnoses but finally opted for melanoma [29][30][31][36][37][38].…”

Section: Discussionmentioning

confidence: 99%

“…In some cases, the clinician considered other diagnoses but finally opted for melanoma [29][30][31][36][37][38]. Furthermore, immunohistochemistry is not helpful for differentiating sarcoma from melanoma, which was suggested by the positivity of some markers, such as S100, HBMG-45, and MelanA [9,[17][18][19][20][21][22][23]26,27,[29][30][31][32][33][34][35][36][37][38][39]. Hence, the rarity of cases of sarcoma mimicking melanoma likely played an important role in opting for melanoma as the reasonable initial diagnosis of choice.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, the main reasons for the second assessment leading to a diagnosis of sarcoma were unusual presentation and uncertainty about the diagnosis, which suggested further investigations to the clinicians [9,[18][19][20][21][22][23]29,30,32,33,35,38]. In a few cases, the second assessment was performed because the patient did not respond to the treatment [17] or during a retrospective review of cases [21,24].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, half of the sarcomas found at the second assessment were CCS [17][18][19][20][21][22][23]26,[29][30][31][32][33]. We believe that the common features shared by CCS and melanoma [7,8] and the lower incidence of CCS were likely to be responsible for the initial misdiagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…We believe that the common features shared by CCS and melanoma [7,8] and the lower incidence of CCS were likely to be responsible for the initial misdiagnosis. When investigated, EWSR1 translocation was found to be positive in almost all cases [17][18][19][20][21][22]26,[29][30][31][32][33]; hence, clinicians may benefit from the investigation of EWSR1 translocation in the initial diagnostic process.…”

Section: Discussionmentioning

confidence: 99%

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Soft Tissue Sarcoma Mimicking Melanoma: A Systematic Review

Cassalia

Cavallin²,

Danese

et al. 2023

Cancers

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Background: Sarcoma may show similarities to malignant melanoma in terms of morphologic and immunohistochemical aspects, making it difficult to differentiate between these two neoplasms during the diagnostic process. This systematic review aims to summarize available evidence on cases of sarcoma that were initially diagnosed as melanoma. Methods: A comprehensive search of the MEDLINE/Pubmed, EMBASE, and SCOPUS databases was conducted through March 2023. We included case series and case reports of sarcoma patients that were initially diagnosed as malignant melanoma. PRISMA guidelines were followed. Results: Twenty-three case reports and four case series with a total of 34 patients were included. The clinical presentation was heterogeneous, and the most involved anatomical regions were lower limbs (24%), head/neck (24%), and upper limbs (21%). IHC positivity was reported for S100 (69%), HMB45 (63%), MelanA (31%), and MiTF (3%). The main reasons for a second assessment were unusual presentation (48%) and uncertain diagnosis (28%). EWSR1 translocation was investigated in 17/34 patients (50%) and found to be positive in 16/17 (94%). The final diagnosis was clear cell sarcoma (50%) or other soft tissue sarcomas (50%). Conclusions: Melanoma and some histotypes of sarcoma share many similarities. In cases of atypical lesions, a second diagnosis should be considered, and ESWR1 translocation should be investigated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Soft Tissue Sarcoma Mimicking Melanoma: A Systematic Review

Cassalia

Cavallin²,

Danese

et al. 2023

Cancers

View full text Add to dashboard Cite

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Soft Tissue Sarcoma Mimicking Melanoma: A Systematic Review

Cassalia¹,

Cavallin²,

Danese³

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Sarcoma may show similarities to malignant melanoma in terms of morphologic and immunohistochemical aspects, hence making it difficult to differentiate between these two neoplasms during the diagnostic process. This systematic review aims to summarize available evidence on cases of sarcoma that were initially diagnosed as melanoma. Methods: A comprehensive search was conducted including MEDLINE/Pubmed, EMBASE and SCOPUS through March 2023. We included case series and case reports of sarcoma patients that were initially diagnosed as malignant melanoma. PRISMA guidelines were followed. Results: Twenty-three case reports and four case series with a total of 34 patients were included. The clinical presentation was heterogeneous, and the most involved anatomical regions were lower limbs (24%), head/neck (24%) and upper limbs (21%). IHC positivity was reported for S100 (69%), HMB45 (63%), MelanA (31%) and MiTF (3%). The main reasons for second assessment were unusual presentation (48%) and uncertain diagnosis (28%). EWSR1 translocation was investigated in 17/34 patients (50%) and found positive in 16/17 (94%). The final diagnosis was clear cell sarcoma (50%) or other soft tissue sarcomas (50%). Conclusions: Melanoma and some histotypes of sarcoma share many similarities. In case of atypical lesions, a second diagnosis should be considered, and ESWR1 translocation should be investigated.

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Atypical clear cell sarcoma of the pleura presenting as large pleural effusion with 22q12 abnormality: A challenging case with twists and turns

Cited by 2 publications

References 63 publications

Soft Tissue Sarcoma Mimicking Melanoma: A Systematic Review

Soft Tissue Sarcoma Mimicking Melanoma: A Systematic Review

Soft Tissue Sarcoma Mimicking Melanoma: A Systematic Review

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