Atypical Contrast Enhancement in Computerized Tomography of Demyelinating Disease

Marano, Gary; Goodwin, Claudia A.; Ko, Jehoon P.

doi:10.1001/archneur.1980.00500570071013

Cited by 12 publications

(4 citation statements)

References 11 publications

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“…However, the ring-enhancing lesion persisted during the stage of clinical regression. Our case supports the view that the duration of clinical symp toms and effectiveness of treatment may not be closely related to the presence of brain enhancement [8,9].…”

Section: Discussionsupporting

confidence: 84%

Sequential Computed Tomography and <sup>123</sup>I-HIPDM Scans in Multiple Sclerosis with Large Plaque

Pozzilli¹,

Pantano

Bozzao

et al. 1987

Eur Neurol

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Section: Discussionsupporting

confidence: 84%

Sequential Computed Tomography and <sup>123</sup>I-HIPDM Scans in Multiple Sclerosis with Large Plaque

Pozzilli¹,

Pantano

Bozzao

et al. 1987

Eur Neurol

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“…Consistent with the reports published to date, pathological concentrations of contrast medium are often found in acute stages of the MS, even after the administration of the usual quantity of the contrast medium [9,11]. With regard to differential diagnosis, these findings are more difficult to assess.…”

Section: Discussionsupporting

confidence: 54%

“…The hypodense, mainly periventricularly arranged loci of demyelinization, sometimes accompanied by varying stages of cerebral atrophy [2,3,11], have been considered characteristic of the disease to date. These diagnostic characteristics now need to be supplemented [7].…”

Section: Discussionmentioning

confidence: 99%

Computed tomography in cases of multiple sclerosis: Problems of differential diagnosis in cases with atypical findings

et al. 1988

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The value of computed tomography in the diagnosis of multiple sclerosis is undisputed. The examination is usually carried out as a routine part of the examination program. We report on the CT results of 112 patients with confirmed or suspected MS. Seventy-three patients were examined without, 39 with intravenous administration of a contrast medium. In 41% of the patients, isolated or multiple hypodense foci were found as a manifestation of a multilocular demyelinization process. In 17.8%, only cerebro-atrophic changes were encountered. In 30.3% of the cases the CT showed normal results. In the group of patients examined with a contrast medium, a pathological contrast medium concentration was found in 30.7%. The differential diagnostic demarcation against other diseases of the CNS with similar CT findings and problems of differential diagnosis with MRI are discussed.

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“…There seems to be general agreement recently that X-ray computerized tomography (CT) has demonstrated the existence of low-density lesions enhanced by contrast medium in the brain of multiple sclerosis (MS) patients (Aita et al, 1978;Lane et al, 1978;Radue and Kendall, 1978;Weinstein et al, 1978;Davis et al, 1979;Hershey et al, 1979;Tritschler et al, 1979;Morariu et al, 1980;Sears et al, 1982;Vifiuela et al, 1982). Neuropa.thologica1 findings at biopsy (Marano et al, 1980;Nelson et al, 1981;Rieth et al, 1981;Sagar et al, 1982) or autopsy (Lebow et al, 1978;Van der Velden et al, 1979;Rieth et al, 1981;Loizou and Cole, 1982;Sagar et al, 1982) revealed cerebral demlyelination in these areas, adjacent to the region olf contrast enhancement. It is presumed that such enhancement results from changes in the blood-brain barrier function produced by active demyelination, which allows extravasation of contrast medium (Gado et al, 1975;Sage, 1982).…”

mentioning

confidence: 98%

Impairment of Blood‐Cerebrospinal Fluid Barrier in Multiple Sclerosis

Takeoka

Shinohara

Furumi

et al. 1983

Journal of Neurochemistry

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The blood-CSF barrier (BCB) function in active multiple sclerosis (MS) was studied by means of CSF proteins analysis using disc electrophoresis and immunofixation. Forty-five CSF samples were obtained by repeat lumbar punctures at various intervals, from four autopsy-proven cases and three male and nine female patients with clinically definite MS. When total protein content was increased, the percentages of prealbumin and tau fraction were decreased significantly in association with the presence of haptoglobin (Hp) polymers in nearly all the samples, as a result of increased permeability of the BCB. Even when the total protein content was normal, Hp polymers were detected in 56% of the samples, and the tau fraction tended to be decreased. Monoclonal immunoglobulin and Hp polymers were both recognized in some cases. The results suggested a more frequent occurrence of BCB impairment in MS than had formerly been revealed by CSF albumin analysis, and accorded with the recent reports of contrast-enhancing lesions of MS brain in computerized tomography.

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Atypical Contrast Enhancement in Computerized Tomography of Demyelinating Disease

Cited by 12 publications

References 11 publications

Sequential Computed Tomography and <sup>123</sup>I-HIPDM Scans in Multiple Sclerosis with Large Plaque

Sequential Computed Tomography and <sup>123</sup>I-HIPDM Scans in Multiple Sclerosis with Large Plaque

Computed tomography in cases of multiple sclerosis: Problems of differential diagnosis in cases with atypical findings

Impairment of Blood‐Cerebrospinal Fluid Barrier in Multiple Sclerosis

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