Atypical femoral fracture following bisphosphonate treatment in a woman with osteogenesis imperfecta—a case report

Unusual Femur Stress Fractures in Children With Osteogenesis Imperfecta and Intramedullary Rods on Long-term Intravenous Pamidronate Therapy

“…9 To the best of our knowledge, there is 1 reported case of atypical femoral fracture in a 75-year-old OI patient who was on alendronate treatment for 3 years. 10 A description of a change in femoral fracture location, with more proximal third fractures in BP-treated children, has also been recently published. 11 The aim of this report is to describe a group of OI children who were on cyclic pamidronate treatment for at least 5 years and who had unusual minimal trauma stress fractures of the femurs over preexisting intramedullary rods (IMR) that were not at periprosthetic stress riser sites.…”

Atypical fracture in a child with osteogenesis imperfecta

“…The literature contains only one report of a patient with osteogenesis imperfecta displaying atypical fracture associated with bisphosphonate therapy [10]; since this patient was 75 years old, the results cannot usefully be compared with those of the present study. The possible appearance of atypical fractures should be borne in mind when dealing with children receiving bisphosphonate therapy, and any unexplained pain should prompt examination using sensitive techniques such as scintigraphy or MRI.…”

Fracture atypique chez un enfant atteint d’une ostéogenèse imparfaite

“…La littérature rapporte un seul article sur un patient atteint d'ostéogenèse imparfaite présentant une fracture atypique associée aux bisphosphonates [10] ; puisque ce patient était âgé de 75 ans, les résultats ne pouvaient pas être comparés à ceux de notre patient. La survenue possible de fractures atypiques doit être gardée à l'esprit chez tout enfant mis sous bisphosphonates et toute douleur inexpliquée doit requérir un examen rapide en utilisant une technique sensible telle que la scintigraphie ou l'IRM.…”