Atypical femur fractures: Refining the clinical picture

Abrahamsen, Bo

doi:10.1002/jbmr.1610

Cited by 15 publications

(12 citation statements)

References 8 publications

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“…The resulting odds ratio of 2 for patients on bisphosphonate treatment to suffer an atypical femoral fractures is contradictory to our finding of an odds ratio of 33 in Paper I. The work by Feldstein was published in the Journal of Bone and Mineral Research (JBMR) along with a commentary by Abrahamsen (2012). In this commentary, the Feldstein study was compared with our study (Paper I) discussing strengths of the one study and limitations of the other.…”

Section: New Literature Challenging Paper Icontrasting

confidence: 80%

Epidemiology, radiology and histology of atypical femoral fractures

Schilcher¹

2013

Acta Orthopaedica

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Section: New Literature Challenging Paper Icontrasting

confidence: 80%

Epidemiology, radiology and histology of atypical femoral fractures

Schilcher¹

2013

Acta Orthopaedica

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“…Therefore, AFFs may occur when a patient has multiple risk factors associated with AFFs, and the summation of these factors overcomes the AFF threshold, leading to stress-related fractures [31]. Consequently, the anatomical features of the lower limb, as well as altered bone tissue properties [31,32], are associated with the development of AFFs.…”

Section: Discussionmentioning

confidence: 99%

The fracture sites of atypical femoral fractures are associated with the weight-bearing lower limb alignment

Saita

Ishijima

Mogami

et al. 2014

Bone

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“…[35]. In an editorial, Abrahamsen [36] suggests that even if BP use leads to an increased risk of AFFs, the overall benefit of reducing hip fractures is associated with a decreased societal burden. The need for balancing benefit versus harm will continue to have to be assessed on an individual basis.…”

Section: Discussionmentioning

confidence: 97%

Identifying Atypical Femoral Fractures—A Retrospective Review

2014

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Subtrochanteric atypical femoral fractures (AFFs) have been reported in patients on osteoporosis therapy (bisphosphonates and denosumab). In 2010, and again in 2013, the ASBMR AFF Task Force developed strict diagnostic criteria for AFFs. This is the first study using these criteria to define the prevalence of AFFs in Canada. This study is a retrospective review of all adult patients (April 2002-March 2013) with an ICD 10 code for hip, femoral or subtrochanteric fracture, from two referral hospitals in Alberta, Canada. All identified as isolated subtrochanteric fractures were further evaluated by chart review, prescription review and examination of radiographs. Of 349 subjects, 79 had isolated subtrochanteric fractures. Of the 70 cases of subtrochanteric fractures that were radiographically assessed (9 films unavailable), 41 fulfilled ASBMR 2013 AFF criteria. The remaining subjects had subtrochanteric fractures but did not meet the ASBMR criteria to qualify as AFFs. There were 11 AFFs in 2012/2013, giving a rate of AFFs of 1.42 per 100,000 50 + year adults, compared to a rate of 103.47 per 100,000 50+ year adults for typical hip fractures. Isolated subtrochanteric fractures are rare. They cannot reliably be identified by ICD coding alone. In this study, only 59 % of all isolated subtrochanteric/femoral shaft fractures fulfilled the ASBMR task force criteria for true AFFs. The rate of typical hip fractures was substantially higher than the rate of AFFs, defined by ASBMR diagnostic criteria.

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Atypical femur fractures: Refining the clinical picture

Cited by 15 publications

References 8 publications

Epidemiology, radiology and histology of atypical femoral fractures

Epidemiology, radiology and histology of atypical femoral fractures

The fracture sites of atypical femoral fractures are associated with the weight-bearing lower limb alignment

Identifying Atypical Femoral Fractures—A Retrospective Review

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